Origanum majorana Attenuates Nephrotoxicity of Cisplatin Anticancer Drug through Ameliorating Oxidative Stress

Abstract

Despite the fact that cisplatin is an important anticancer drug, its clinical utilization is limited by nephrotoxicity during long term medication. Combined cisplatin chemotherapy with plant extracts can diminish toxicity and enhance the antitumor efficacy of the drug. This study evaluated the effect of Originum majorana ethanolic extract (OMEE) on cisplatin-induced nephrotoxicity. Eighteen male rats were divided into three groups as follows: a control group, a group treated with cisplatin (3 mg/kg body weight), and a group that received both cisplatin and OMEE (500 mg/kg body weight) for 14 days. Cisplatin induced a significant increase in creatinine, urea, uric acid, blood urea nitrogen, malondialdehyde, and nitric oxide levels. However, glutathione, superoxide dismutase, and catalase levels were significantly diminished. Conversely, OMEE significantly modulated the renal and oxidative markers negatively impacted by cisplatin. OMEE significantly reduced the effects of cisplatin-induced changes in renal and oxidative markers, possibly through its free radical scavenging activity. Thus, OMEE may be combined with cisplatin to alleviate nephrotoxicity in cancer chemotherapy.

Evaluation of Plant Food Extracts in Experimental Model of Alzheimer's Like Disease Induced by Aluminum Lactate in Rats

“…The antioxidant and anti-inflammatory effect of Origanum majorana extracts proved in the present study agreed with the work of Soliman et al (2016). Carnosic acid, a highly labile diterpene phenol with a structure similar to rosmarinic acid in addition to its derivative carnosol, that are present in Origanum majorana, both have antioxidant and anti-inflammatory activities.…”

“…Aβ, present in Al-animal model of ALD as well as in AD patients, induces the production of hydrogen peroxide, lipid peroxide and superoxide in neurons that contribute in the formation of amyloid plaques and neurofibrillary tangles. Oxidative stress could promote AD by stimulating macroautophagy of Aβ that may further induce cell death by destabilizing lysosomal membranes (Swomley et al, 2014;Prema et al, 2016). Al induces apoptosis in hippocampus and cortex mainly by the down regulation of anti-apoptotic mediators and upregulation of pro-apoptotic factors (Chaudhary et al, 2014).…”

“…Blood samples were divided into two parts one mixed with trisodium citrate for determination of erythrocyte sedimentation rate (ESR) according to Westergren (1921). The second part of blood was mixed with heparin as anticoagulant, followed by centrifugation at 3000 rpm for 15 min to separate plasma for determination of vitamin C (Jagota and Dani, 1982), vitamin E (Desai and Machlin, 1985), nitrite (Montogomery and Dymock, 1961), cholinesterase (ChE) activity (Den Blaauwen et al, 1983), tumor necrosis factor-alpha (TNF-α) (Stepaniak et al, 1995), and malondialdehyde (MDA) according to Satoh (1978). Rats were dissected, skulls were opened with bone scissor and brains were received on ice, and used for determination of acetyl cholinesterase activity (AChE) according to Ellman et al (1961) and MDA (Ohkawa et al, 1979).…”

Etnobotanik Amaçlı Kullanılan Origanum Acutidens Bitkisinin Toplam Fenolik-Flovonoid İçeriği, Fenolik Bileşikleri ve Element Analizi

“…Ülkemizde kekik adıyla da bilinen, Orignaum cinsine ait taksonların çoğu, halk hekimliğinde yaygın olarak baş ağrısı, baş dönmesi, öksürük, grip, gastrointestinal hastalık, bronşit, yüksek kolesterol, diyabet, karın ağrısı hipertansiyon ve diş ağrısı gibi hastalıkların tedavisinde kullanılmaktadır [8]. Origanum türleri üzerine yapılan çalışmalar antimikrobiyal, antikanser, antidiyabetik, antioksidan, antibakteriyel, antifungal, antinosiseptif ve antilipaz gibi biyolojik aktiviteler göstermiştir [9][10][11][12][13][14][15][16][17]. Bu çalışmalarla beraber gıda veya ilaç olarak tüketilen bitkilerin içerdiği elementlerin analiz edilmesi de son derece önem arz etmektedir.…”

Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites

“…Previous phytochemical and pharmaceutical studies on this species have resulted in the isolation of phenolic compounds, which are responsible for antioxidant and anticancer activities. [36] Recent works on Origanum species exhibited a wide range of biological activities such as antimicrobial, [37] anticancer, [38] antioxidant, [39] antidiabetes, [40] antibacterial, [41] antifungal, [42] antinociceptive, [43] and antilipase [44] properties. Although extensive knowledge on the chemical composition of essential oil on Origanum species is available, the antioxidative activity of secondary metabolites isolated from Origanum minutiflorum O. Schwarz & P.H has not been investigated previously.…”