Origami of KR-12 Designed Antimicrobial Peptides and Their Potential Applications
Jayaram Lakshmaiah Narayana,
Abraham Fikru Mechesso,
Imran Ibni Gani Rather
et al.
Abstract:This review describes the discovery, structure, activity, engineered constructs, and applications of KR-12, the smallest antibacterial peptide of human cathelicidin LL-37, the production of which can be induced under sunlight or by vitamin D. It is a moonlighting peptide that shows both antimicrobial and immune-regulatory effects. Compared to LL-37, KR-12 is extremely appealing due to its small size, lack of toxicity, and narrow-spectrum antimicrobial activity. Consequently, various KR-12 peptides have been en… Show more
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