Origami lattices with free-form surface ornaments

Janbaz, Shahram; Noordzij, Niels; Widyaratih, Dwisetya Safirna; Hagen, C. W.; Fratila‐Apachitei, Lidy E.; Zadpoor, Amir A.

doi:10.1126/sciadv.aao1595

Cited by 58 publications

(47 citation statements)

References 54 publications

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“…Despite the advances in micro/nanofabrication techniques, it is very challenging to create nanopatterns on 3D-shaped devices as the current patterning techniques are mostly only applicable to flat surfaces. Novel strategies have been therefore proposed to create 3D structures from flat sheets that are first ornamented with nanopatterns and are then (self-)folded into complex 3D shapes using origami-based approaches [31]. This could be promising for translating bactericidal and osteogenic nanopatterns to clinical use.…”

Section: Discussionmentioning

confidence: 99%

“…on cell attachment, proliferation, and differentiation, as well as bacterial adhesion and motility, revealing the fact that both eukaryote and prokaryote cells could sense the surface topography at both micro-and nano-scales [28][29][30]. Due to the recent advances in micro-and nano-fabrication techniques, it is now feasible to produce surfaces with arbitrarily complex and precisely controlled surface nanotopography, also known as nanopatterns [29,[31][32][33]. It has been shown that nanopatterns are powerful tools for directing the stem cell fate [34].…”

Section: Introductionmentioning

confidence: 99%

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Bactericidal effects of nanopatterns: A systematic review

et al. 2019

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We systematically reviewed the currently available evidence on how the design parameters of surface nanopatterns (e.g. height, diameter, and interspacing) relate to their bactericidal behavior. The systematic search of the literature resulted in 46 studies that satisfied the inclusion criteria of examining the bactericidal behavior of nanopatterns with known design parameters in absence of antibacterial agents. Twelve of the included studies also assessed the cytocompatibility of the nanopatterns. Natural and synthetic nanopatterns with a wide range of design parameters were reported in the included studies to exhibit bactericidal behavior. However, most design parameters were in the following ranges: heights of 100-1000 nm, diameters of 10-300 nm, and interspacings of <500 nm. The most commonly used type of nanopatterns were nanopillars, which could kill bacteria in the following range of design parameters: heights of 100-900 nm, diameters of 20-207 nm, and interspacings of 9-380 nm. The vast majority of the cytocompatibility studies (11 out of 12) showed no adverse effects of bactericidal nanopatterns with the only exception being nanopatterns with extremely high aspect ratios. The paper concludes with a discussion on the evidence available in the literature regarding the killing mechanisms of nanopatterns and the effects of other parameters including surface affinity of bacteria, cell size, and extracellular polymeric substance (EPS) on the killing efficiency. Statement of significance The use of nanopatterns to kill bacteria without the need for antibiotics represents a rapidly growing area of research. However, the optimum design parameters to maximize the bactericidal behavior of such physical features need to be fully identified. The present manuscript provides a systematic review of the bactericidal nanopatterned surfaces. Identifying the effective range of dimensions in terms of height, diameter, and interspacings, as well as covering their impact on mammalian cells, has enabled a comprehensive discussion including the bactericidal mechanisms and the factors controlling the bactericidal efficiency. Overall, this review helps the readers have a better understanding of the state-of-the-art in the design of bactericidal nanopatterns, serving as a design guideline and contributing to the design of future experimental studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bactericidal effects of nanopatterns: A systematic review

et al. 2019

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“…Nanotopography describes the structural features such as nanopatterns, nanopores, or surface topography which enhance osteoinductivity and osteointegration of scaffolds [6]. Cell fate and differentiation are influenced by specific nanotopography structures [137]. Different lattices, made by repeats of identically sized and shaped cells, were tested by unfolding through the flattening of the cells.…”

Section: Cv-tebg and Nanotechnology-related Scaffoldsmentioning

confidence: 99%

Bone Regeneration, Reconstruction and Use of Osteogenic Cells; from Basic Knowledge, Animal Models to Clinical Trials

Hutchings

Moncrieff

Dompe

et al. 2020

JCM

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The deterioration of the human skeleton’s capacity for self-renewal occurs naturally with age. Osteoporosis affects millions worldwide, with current treatments including pharmaceutical agents that target bone formation and/or resorption. Nevertheless, these clinical approaches often result in long-term side effects, with better alternatives being constantly researched. Mesenchymal stem cells (MSCs) derived from bone marrow and adipose tissue are known to hold therapeutic value for the treatment of a variety of bone diseases. The following review summarizes the latest studies and clinical trials related to the use of MSCs, both individually and combined with other methods, in the treatment of a variety of conditions related to skeletal health. For example, some of the most recent works noted the advantage of bone grafts based on biomimetic scaffolds combined with MSC and growth factor delivery, with a greatly increased regeneration rate and minimized side effects for patients. This review also highlights the continuing research into the mechanisms underlying bone homeostasis, including the key transcription factors and signalling pathways responsible for regulating the differentiation of osteoblast lineage. Paracrine factors and specific miRNAs are also believed to play a part in MSC differentiation. Furthering the understanding of the specific mechanisms of cellular signalling in skeletal remodelling is key to incorporating new and effective treatment methods for bone disease.

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“…Furthermore, development of nano-fabrication techniques, that allow for decorating the surface of 3D printed biomaterials with such nanoscale topographies, is technologically challenging, particularly when trying to apply nano-topographical features to topologically ordered volume-porous biomaterials. A combination of origami techniques and self-folding techniques [ 37 ] has been recently proposed as a possible way to approach this problem, by folding the porous biomaterials from a flat surface. The research into foldable biomaterials is, nevertheless, at its fancy, and requires many further developments.…”

Section: Bio-functionalizationmentioning

confidence: 99%

Current Trends in Metallic Orthopedic Biomaterials: From Additive Manufacturing to Bio-Functionalization, Infection Prevention, and Beyond

Zadpoor

2018

IJMS

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There has been a growing interest in metallic biomaterials during the last five years, as recent developments in additive manufacturing (=3D printing), surface bio-functionalization techniques, infection prevention strategies, biodegradable metallic biomaterials, and composite biomaterials have provided many possibilities to develop biomaterials and medical devices with unprecedented combinations of favorable properties and advanced functionalities. Moreover, development of biomaterials is no longer separated from the other branches of biomedical engineering, particularly tissue biomechanics, musculoskeletal dynamics, and image processing aspects of skeletal radiology. In this editorial, I will discuss all the above-mentioned topics, as they constitute some of the most important trends of research on metallic biomaterials. This editorial will, therefore, serve as a foreword to the papers appearing in a special issue covering the current trends in metallic biomaterials.

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Origami lattices with free-form surface ornaments

Abstract: We introduce folding strategies to fabricate lattice structures with arbitrarily complex surface (nano-) ornaments.

Cited by 58 publications

References 54 publications

Bactericidal effects of nanopatterns: A systematic review

Bactericidal effects of nanopatterns: A systematic review

Bone Regeneration, Reconstruction and Use of Osteogenic Cells; from Basic Knowledge, Animal Models to Clinical Trials

Current Trends in Metallic Orthopedic Biomaterials: From Additive Manufacturing to Bio-Functionalization, Infection Prevention, and Beyond

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