Orientia tsutsugamushi

Wongsantichon, Jantana; Jaiyen, Yanin; Dittrich, Sabine; Salje, Jeanne

doi:10.1016/j.tim.2020.02.014

Cited by 14 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the 31 provinces, 11/31 (35.48%) and 6/31 (19.35%) provinces were identified as cold spots and hot spots, respectively. The remaining 14/31 (Wongsantichon et al, 2020 Hainan, Fujian and Jiangxi Hainan, Fujian and Jiangxi), while the cold spots were mainly distributed in the north (Heilongjiang, Jilin, Liaoning, Inner Mongolia, Hebei, Shanxi, Shaanxi, Ningxia, Gansu, Qinghai and Xinjiang)(Fig. 4) Among the six hot spots, the upward trends of Yunnan, Guangdong, Guangxi and Hainan were faster than the overall trend.…”

Section: Spatial Heterogeneitymentioning

confidence: 99%

“…Scrub typhus is a natural-focus disease caused by Orientia tsutsugamushi, which is mainly carried by rodents and chigger mites, and transmitted through the bite of an infected chigger mite larval 3 / 19 occasionally. This disease is characterized of fever, eschar, rash and lymph node enlargement, and can even lead to multiple organ failure and death in severe cases with a fatality rate of up to 70% (Wongsantichon et al, 2020). O.tsutsugamushi is geographically endemic across vast areas of Asia and islands in the Pacific and Indian Oceans.…”

Section: Introductionmentioning

confidence: 99%

“…O.tsutsugamushi is geographically endemic across vast areas of Asia and islands in the Pacific and Indian Oceans. Scrub typhus is one of the most widespread and severe infections of rickettsia which lead to more than one million infective cases each year(Tshokey et al, 2017; Wongsantichon et al, 2020). An increasing number of research(Izzard et al, 2010; Luce-Fedrow et al, 2018; Masakhwe et al, 2018; Weitzel et al, 2016; Weitzel et al, 2019) indicated that the distribution of scrub typhus was no longer limited to the Asia-Pacific region, but is spreading worldwide.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spatiotemporal heterogeneity and the long-term impact of meteorological, environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

Qian

Zhu

et al. 2022

Preprint

View full text Add to dashboard Cite

Large-scale outbreaks of scrub typhus combined with the emergence of this vector-borne rickettsiosis in new areas indicate that this disease remains seriously neglected. This study aimed to explore the long-term changes and regional leading factors of scrub typhus in China, so as to provide fresh insights for the prevention and control of this disease. In this study, a Bayesian space-time hierarchical model (BSTHM) was used to identify the long-term spatiotemporal heterogeneity of scrub typhus and quantify the association between meteorological factors and scrub typhus in southern and northern China from 2012 to 2018. GeoDetector model was used to quantify the dominant forces of environmental and socioeconomic factors in the Northern and the Southern China. Scrub typhus often appeared in summer and autumn (June to November), and epidemically peaked in October, with obvious temporal seasonality . Spatially, the hot spots (high-risk regions) were concentrated in the south, on the contrary the cold spots (low-risk regions) in the north. In addition, the main meteorological factor, average temperature, gave a significant impact in both areas. The average temperature increased by 1 ?, resulting in a decrease of 1.10% in southern China and an increase of 0.96% in northern China in the risk of scrub typhus. The determinant environmental and socio-economic factors of scrub typhus in the two areas were altitude and per capita GDP, with q-values of 0.91 and 0.87, respectively. Meteorological, environmental and socio-economic factors had a significant impact on the distribution of scrub typhus, with obvious seasonality and spatial heterogeneity. This study provides helpful suggestions and basis for reasonably allocating resources and controlling the occurrence of scrub typhus.

show abstract

Section: Spatial Heterogeneitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spatiotemporal heterogeneity and the long-term impact of meteorological, environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

Qian

Zhu

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…O. tsutsugamushi encodes multiple T1SS ankyrin-repeatcontaining effector proteins (Anks), known to interact with host cells and largely target the endoplasmic reticulum (113). Notably, Ank9 was the first effector shown to function during infection whereby a unique Ank9 motif mimics the GRIP domain of the host golgins, supporting O. tsutsugamushi localization to the host Golgi.…”

Section: O Tsutsugamushimentioning

confidence: 99%

Anaplasmataceae: Dichotomous Autophagic Interplay for Infection

2021

View full text Add to dashboard Cite

Autophagy is a vital conserved degradative process that maintains cellular homeostasis by recycling or eliminating dysfunctional cellular organelles and proteins. More recently, autophagy has become a well-recognized host defense mechanism against intracellular pathogens through a process known as xenophagy. On the host-microbe battlefield many intracellular bacterial pathogens have developed the ability to subvert xenophagy to establish infection. Obligately intracellular bacterial pathogens of the Anaplasmataceae family, including Ehrlichia chaffeensis, Anaplasma phaogocytophilium and Orientia tsutsugamushi have developed a dichotomous strategy to exploit the host autophagic pathway to obtain nutrients while escaping lysosomal destruction for intracellular survival within the host cell. In this review, the recent findings regarding how these master manipulators engage and inhibit autophagy for infection are explored. Future investigation to understand mechanisms used by Anaplasmataceae to exploit autophagy may advance novel antimicrobial therapies and provide new insights into how intracellular microbes exploit autophagy to survive.

show abstract

“…OT, the Gram negative obligate intracellular bacteria are suspected to be one of the causes of Acute Encephalitis Syndrome (AES) and Acute Febrile Illness (AFI) that often remain underdiagnosed since the initial symptoms are very common and similar to that of flu or any other viral infection ( Wongsantichon et al, 2020 ). Also, the lack of the pathognomonic eschars, characteristic of ST, adds to the misdiagnosis ( Kundavaram et al, 2013 ; Prakash, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Genotypic Characterization of Orientia tsutsugamushi Isolated From Acute Encephalitis Syndrome and Acute Febrile Illness Cases in the Gorakhpur Area, Uttar Pradesh, India

Nanaware

Desai²,

Banerjee³

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

Scrub typhus infections caused by Orientiatsutsugamushi (OT), continue to remain underdiagnosed globally, due to the lack of distinctive symptoms. The elusive nature of the Acute Encephalitis Syndrome (AES) outbreak in Gorakhpur, Uttar Pradesh that claimed numerous pediatric lives was the driving force of this study which involved serological diagnosis (IgM–ELISA), isolation of OT in cell culture, confirmation by PCR, and characterization by Sanger sequencing. In total, 12 out of 36 patients were seropositive, of which 4 were positive by PCR. Upon enrichment in cell culture, additional 3 patients (including two seronegative) were detected positive by PCR. In total, three of these 7 patients were found to be infected with two strains of OT. Taken together, this study for the first time reports the occurrence of dual infections in addition to three circulating OT genotypes (Gilliam, Kato, and Karp-like) and highlights the significance of enriching OT in cell culture systems for efficient molecular detection.

show abstract

Orientia tsutsugamushi

Cited by 14 publications

References 9 publications

Spatiotemporal heterogeneity and the long-term impact of meteorological, environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

Spatiotemporal heterogeneity and the long-term impact of meteorological, environmental and socio-economic factors of scrub typhus in China from 2012 to 2018

Anaplasmataceae: Dichotomous Autophagic Interplay for Infection

Genotypic Characterization of Orientia tsutsugamushi Isolated From Acute Encephalitis Syndrome and Acute Febrile Illness Cases in the Gorakhpur Area, Uttar Pradesh, India

Contact Info

Product

Resources

About