2013
DOI: 10.1186/2046-7648-2-2
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Orientation and disorientation in aviation

Abstract: On the ground, the essential requirement to remain orientated is a largely unconscious activity. In flight, orientation requires a conscious effort by the pilot particularly when the visual environment becomes degraded and a deceptive force environment becomes the frame of reference. Furthermore, an unusual force environment can determine the apparent location of objects within a limited visual scene, sometimes with disastrous consequences. This review outlines the sources of pilot disorientation that arise fr… Show more

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Cited by 27 publications
(25 citation statements)
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References 8 publications
(8 reference statements)
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“…Typically, spatial awareness is enabled by the multimodal integration of visual, somatosensory, and vestibular information in the medial superior temporal area 20 . However, the conclusions resulting from this functional processing are usually based on standard, earthbound situations and might be unreliable during flight operations, particular when additionally affected by reduced visibility (e.g., clouds, fog, smoke, low light) and spatial disorientation due to illusions within the human sensory system (e.g., somatogravic or oculogravic illusions) 21 . Therefore, pilots have to routinely supplement their sense of orientation by the use of artificial instruments (i.e., attitude indicators).…”
Section: Discussionmentioning
confidence: 99%
“…Typically, spatial awareness is enabled by the multimodal integration of visual, somatosensory, and vestibular information in the medial superior temporal area 20 . However, the conclusions resulting from this functional processing are usually based on standard, earthbound situations and might be unreliable during flight operations, particular when additionally affected by reduced visibility (e.g., clouds, fog, smoke, low light) and spatial disorientation due to illusions within the human sensory system (e.g., somatogravic or oculogravic illusions) 21 . Therefore, pilots have to routinely supplement their sense of orientation by the use of artificial instruments (i.e., attitude indicators).…”
Section: Discussionmentioning
confidence: 99%
“…Exosomal RNA SNORA22 has been shown to be overexpressed in pancreatic ductal adenocarcinoma (PDAC) (8). In a study of prostate cancer xenografts, SNORA22 was discovered to be expressed differently in metastatic and non-metastatic xenografts (9). Breast cancer (10), ovarian cancer (11), gastric cancer (12), and hepatocellular carcinoma ( 12) have all been linked to miR939 (13).…”
Section: Discussionmentioning
confidence: 99%
“…Throughout the hematological system, ZFX has been implicated in BCR-induced B-cell proliferation and survival (8). ZFX was also shown to be an inhibitor of acute T-lymphoblastic leukemia and myeloid leukemia differentiation (9), and was revealed to be required for imatinib resistance and proliferation of chronic myeloid leukemia cells (10). In nonhematopoietic malignancies, ZFX has been implicated in tumor development and cell proliferation in a number of solid tumors.…”
Section: Discussionmentioning
confidence: 99%