Oridonin suppresses transplant rejection by depleting T cells from the periphery

Guo, Wenzhi; Zheng, Peng; Zhang, Jiakai; Ming, Liang; Zhou, Chen; Zhang, Shuijun

doi:10.1016/j.intimp.2013.10.023

Cited by 16 publications

(12 citation statements)

References 21 publications

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“…In the present study, we found that ORI can decrease immunoglobulin concentrations (IgA and IgG) in the jejunum. The mechanisms of ORI’s immune-protecting properties may be partially attributed to T cell depletion in the peripheral immune system [ 19 ]. Additional studies will be required before the potential applications of ORI in feeding practices are fully understood.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary oridonin supplementation on growth performance, gut health, and immune response of broilers infected with Salmonella pullorum

Zheng

Wang

et al. 2018

Ir Vet J

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BackgroundThe effects of dietary supplementation of oridonin (ORI) on growth performance, cecal microbiota, epithelium development and antioxidant and immune parameters of broilers infected with S. pullorum were studied. A total of 300 1-d-old male chicks were selected and divided into 5 trial groups (6 replicates of 10 chickens): 1) nonchallenge control chicks (CON), 2) chicks treated with Salmonella Challenged Control (SCC), 3) chicks treated with S. pullorum challenge and 50 mg/kg ORI (O1), 4) chicks treated with S. pullorum challenge and 80 mg/kg ORI (O2), and 5) chicks treated with S. pullorum challenge and 100 mg/kg ORI (O3).ResultsThe results showed that S. pullorum had no effect on the feed intake (FI), body weight gain (BWG) or feed conversion ratio (FCR) of broilers compared with the values measured for the CON group (P > 0.05). However, compared with the characteristics of CON, S. pullorum showed effects on the counts of Salmonella and Lactobacillus at 7 d and at 14 d (P < 0.05), on jejunal development at 7 d (P < 0.05), and on jejunal immunoglobulin A (IgA) concentration at 7 d (P < 0.05). The addition of 100 mg/kg ORI had the greatest effect on the counts of Lactobacillus and Salmonella in cecal content (P < 0.05), malonaldehyde (MDA) content in the jejunum (P < 0.05), villi height of the small intestine, and IgA concentrations in the jejunum (P < 0.05).ConclusionsThe results suggest that ORI can improve Salmonella-induced immune responses and protect intestinal health, not only through its immune inhibitory properties but also through its multi-protective effects on gut health.

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Section: Discussionmentioning

confidence: 99%

Effect of dietary oridonin supplementation on growth performance, gut health, and immune response of broilers infected with Salmonella pullorum

Zheng

Wang

et al. 2018

Ir Vet J

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“…Oridonin, an ent-kaurane diterpenoid compound (C20H28O6), isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects, such as anti-tumor, anti-bacterial, and anti-inflammatory properties (Guo et al, 2013;Bu et al, 2014;. However, the effect of oridonin on human OvCa cell lines has not been determined.…”

Section: Introductionmentioning

confidence: 99%

Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling

Xiao¹,

Chen²,

Qin³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Oridonin, an ent-kaurane diterpenoid compound isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects such as anti-tumor, anti-bacterial, and anti-inflammatory properties. However, the effect of oridonin on human ovarian cancer cell lines has not been determined. In this study, we demonstrated that oridonin inhibited ovarian cancer cell proliferation, migration and invasion in a dose-dependent manner. Furthermore, we showed oridonin inhibited tumor growth of ovarian cancer cells (SKOV3) in vivo. We then assessed mechanisms and found that oridonin specifically abrogated the phosphorylation/activation of mTOR signaling. In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway. Keywords

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“…In birds, few studies have investigated the immunostimulatory effect of ORI. About our present results, the lower cytokines levels produced in ORI-treated broilers is likely related to ORI’s anti-inflammatory potential through the repression of T-cell immune responses [ 6 ]. Our results are similar to previous studies and further indicate that certain terpenoid compounds may play their anti-inflammatory effects through the regulation of Th 1 /Th 2 cytokine secretion levels or repression of T-cell immune responses.…”

Section: Discussionmentioning

confidence: 60%

“…It has been well documented that the inclusion of oridonin in rat diets can promote the development of immune organs, stimulate organ immunoglobulin secretion, and prohibit the colonization of Escherichia coli and Salmonella . Additionally, ORI component supplementation has been reported to enhance T lymphocyte responses in vivo [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary supplementation with oridonin on the growth performance, relative organ weight, lymphocyte proliferation, and cytokine concentration in broiler chickens

Zheng

Wang

et al. 2018

BMC Vet Res

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Background: The present study was conducted to investigate the effects of oridonin (ORI) on growth performance, relative organ weight, lymphocyte proliferation, phagocytic function of neutrophils, and cytokine concentration in broiler chickens. A total of 240 one-day-old Arbor Acres male broilers were randomly assigned to four treatments with six replicate pens of 10 broiler chickens per pen. Broiler chickens were fed diets based on four levels of dietary ORI (0, 50, 80 and 100 mg/kg) for a 42-d feeding trial. The experimental diets were fed in three phases: 1 to 14 d, 15 to 28 d and 29 to 42 d. Results:The results indicated that ORI has no influence on the growth performance (P > 0.05). However, ORI increased the relative weights of spleen and bursa, the number of proliferation peripheral blood T and B lymphocytes, the phagocytic rate of neutrophils, as well as the Interleukin-2 (IL-2), Interleukin-4 (IL-4) and tumor necrosis factor-a (TNF-a) serum concentrations in serum in broilers at days 14, 28 and 42 (P < 0.05).

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Oridonin suppresses transplant rejection by depleting T cells from the periphery

Cited by 16 publications

References 21 publications

Effect of dietary oridonin supplementation on growth performance, gut health, and immune response of broilers infected with Salmonella pullorum

Effect of dietary oridonin supplementation on growth performance, gut health, and immune response of broilers infected with Salmonella pullorum

Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling

Effects of dietary supplementation with oridonin on the growth performance, relative organ weight, lymphocyte proliferation, and cytokine concentration in broiler chickens

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