Oridonin ameliorates carbon tetrachloride‐induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome

Liu, Dong; Qin, Hailong; Bi-xian, Yang; Du, Bin; Xue-lin, Yun

doi:10.1002/ddr.21649

Cited by 34 publications

(23 citation statements)

References 32 publications

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“…A same story occurs in CCl 4 toxicity. The CCl 4 is able to induce liver fibrosis via inflammation, oxidative stress and stimulates apoptosis ( Liu et al, 2020a ; Munakarmi et al, 2020 ; Zhang et al, 2020b ). In inhibition of CCl 4 -mediated liver injury, curcumin down-regulates TGF-β1/Smad3 signaling pathway ( Peng et al, 2018 ).…”

Section: Curcumin and Transforming Growth Factor-beta In Different DImentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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Immune response, proliferation, migration and angiogenesis are juts a few of cellular events that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have documented that TGF-β undergoes abnormal expression in different diseases, e.g., diabetes, cancer, fibrosis, asthma, arthritis, among others. This has led to great fascination into this signaling pathway and developing agents with modulatory impact on TGF-β. Curcumin, a natural-based compound, is obtained from rhizome and roots of turmeric plant. It has a number of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-diabetes and so on. Noteworthy, it has been demonstrated that curcumin affects different molecular signaling pathways such as Wnt/β-catenin, Nrf2, AMPK, mitogen-activated protein kinase and so on. In the present review, we evaluate the potential of curcumin in regulation of TGF-β signaling pathway to corelate it with therapeutic impacts of curcumin. By modulation of TGF-β (both upregulation and down-regulation), curcumin ameliorates fibrosis, neurological disorders, liver disease, diabetes and asthma. Besides, curcumin targets TGF-β signaling pathway which is capable of suppressing proliferation of tumor cells and invading cancer cells.

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Section: Curcumin and Transforming Growth Factor-beta In Different DImentioning

confidence: 99%

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

et al. 2020

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“…reported that oridonin can target NLRP3 to exert its antiinflammatory activity and that the dose needed for inhibition NLRP3 was about 10 times lower than the dose needed for TNF-α inhibition (He et al, 2018). In addition, the inhibition of oridonin on NLRP3 was confirmed in LPS-induced acute lung injury (Yang et al, 2019) and carbon tetrachloride-induced liver fibrosis (Liu, Qin, et al, 2020) in mice.…”

Section: Discussionmentioning

confidence: 98%

Oridonin alleviates d‐GalN/LPS‐induced acute liver injury by inhibiting NLRP3 inflammasome

Zhang

Chen

Zhan

et al. 2020

Drug Development Research

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Acute liver injury (ALI) is a serious syndrome that is associated with high mortality, but there are few effective treatments. The activation of NLRP3 inflammasome is associated with ALI. Oridonin is a natural substance with an anti-inflammatory effect and has been reported to be an inhibitor of NLRP3. The aim of this study was to investigate the protective effect of oridonin on D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced ALI and whether the effect is mediated by NLRP3. Mice were pretreated with oridonin (5 or 10 mg/kg) for 3 days. Then, they were injected with D-GalN (400 mg/kg) and LPS (40 μg/kg). The levels of inflammatory factors were measured by RT-PCR, Western blot, and enzyme-linked immunosorbent assay. We confirmed that oridonin significantly alleviated ALI induced by D-GalN/LPS in mice.Oridonin markedly decreased the inflammatory response by reducing the levels of inflammatory cytokines. More importantly, oridonin markedly reduced the expression of NLRP3, caspase-1, IL-18, and IL-1β. This study showed that oridonin has a protective effect on D-GalN/LPS-induced ALI, and the underlying mechanisms may be associated with the inhibition of the NLRP3 inflammatory pathways.

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“…Besides, this compound could inhibit angiogenesis and EMT related to VEGF-A ( Li C. Y. et al, 2018 ), block Notch signaling pathway to inhibit the growth and metastasis of breast cancer ( Xia et al, 2017 ), and induce autophagy to promote apoptosis ( Li and Yang, 2015 ). In addition to its above anti-tumor effects, there is growing evidences that oridonin exhibits other anti-tumor activities such as colorectal cancer ( Bu H. et al, 2019 ), pancreatic cancer ( Liu D. et al, 2020 ), gallbladder cancer ( Chen, et al, 2019 ), prostate cancer ( Lu et al, 2017 ) and so on. Given that pathway defects have been recognized by most chemotherapies, oridonin may be a logical botanical for future researches of tumor adjuvant therapy.…”

Section: Pharmacologymentioning

confidence: 99%

Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity

Zhang

et al. 2021

Front. Pharmacol.

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Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon rubescens (Hemsl.) H.Hara, is widely present in numerous Chinese medicine preparations. The purpose of this review focuses on providing the latest and comprehensive information on the pharmacology, pharmacokinetics and toxicity of oridonin, to excavate the therapeutic potential and explore promising ways to balance toxicity and efficacy of this natural compound. Information concerning oridonin was systematically collected from the authoritative internet database of PubMed, Elsevier, Web of Science, Wiley Online Library and Europe PMC applying a combination of keywords involving “pharmacology,” “pharmacokinetics,” and “toxicology”. New evidence shows that oridonin possesses a wide range of pharmacological properties, including anticancer, anti-inflammatory, hepatorenal activities as well as cardioprotective protective activities and so on. Although significant advancement has been witnessed in this field, some basic and intricate issues still exist such as the specific mechanism of oridonin against related diseases not being clear. Moreover, several lines of evidence indicated that oridonin may exhibit adverse effects, even toxicity under specific circumstances, which sparked intense debate and concern about security of oridonin. Based on the current progress, future research directions should emphasize on 1) investigating the interrelationship between concentration and pharmacological effects as well as toxicity, 2) reducing pharmacological toxicity, and 3) modifying the structure of oridonin—one of the pivotal approaches to strengthen pharmacological activity and bioavailability. We hope that this review can provide some inspiration for the research of oridonin in the future.

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Oridonin ameliorates carbon tetrachloride‐induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome

Cited by 34 publications

References 32 publications

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review

Oridonin alleviates d‐GalN/LPS‐induced acute liver injury by inhibiting NLRP3 inflammasome

Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity

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