Organotin (IV) complexes derived from tridentate Schiff base ligands: Synthesis, spectroscopic analysis, antimicrobial and antioxidant activity

Saroya, Sonia; Asija, Sonika; Kumar, Naresh; Deswal, Yogesh; Devi, Jai

doi:10.1016/j.jics.2022.100379

Cited by 21 publications

(4 citation statements)

References 57 publications

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“…The reaction mixture was refluxed constantly for 5 h. The solid product obtained was filtered off, washed with hexane, followed by recrystallization from methanol and finally dried over vacuum. [21,22] The synthesis of 4-Chloro-2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,-2,4-triazol-4-yl)imino)methyl)phenol is presented in Scheme 1. O (0.659 g, 3 mmol) in 1:1 ratio.…”

Section: Synthesis Of 4-amino-5-(pyridin-4-yl)-4h-124-triazole-3-thio...mentioning

confidence: 99%

Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Deswal

Asija

Tufail³

et al. 2023

Applied Organom Chemis

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In search of novel medications that could be effective in preventing and treating diabetes, four new [Co(L)(H 2 O) 3 ] (2), [Ni(L)(H 2 O) 3 ] (3), [Cu(L)(H 2 O)] (4) and [Zn(L)(H 2 O)] (5) complexes were synthesized from 4-Chloro-2-(((3-mercapto-5-[pyridin-4-yl]-4H-1,2,4-triazol-4-yl)imino)methyl)phenol ligand (H 2 L),which is obtained by the condensation of 5-chlorosalicylaldehyde with 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol in 1:1 ratio. The Fouriertransform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR)( 1 H and 13 C), elemental analyses, UV-visible, electron spin resonance (ESR), thermogravimetric analysis (TGA), scanning electron microscopy, energy dispersive X-ray analysis (EDAX), and X-ray diffraction (XRD) studies were used to successfully characterize the compounds. The ligand act in a tridentate manner and coordinates to the metal ions through N azomethine , O phenolic and S thiol functionalities. On the premise of their spectral and physico-analytical data; octahedral geometry for complex 2 and 3, while square planar and tetrahedral geometry for complex 4 and 5 was proposed. Theoretical calculations of the synthesized compounds have been performed by using density functional theory (DFT)/B3LYP method and parameters such as HOMO-LUMO energy values and MESP were calculated. In vitro examinations against α-amylase and α-glucosidase reveal promising results for the compounds. Nickel (II) complex(3) against α-amylase and zinc (II) complex (5) against α-glucosidase were found to be good inhibitors. Molecular docking experiments against the receptors 1BSI and 5ZCC were done to support the observation and considerable

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Section: Synthesis Of 4-amino-5-(pyridin-4-yl)-4h-124-triazole-3-thio...mentioning

confidence: 99%

Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Deswal

Asija

Tufail³

et al. 2023

Applied Organom Chemis

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“…In particular, Schiff base organotin(IV) carboxylates have demonstrated potent antitumor properties, at times even surpassing the efficacy of cisplatin, a widely used platinum-based anticancer drug. [19][20][21][22][23][24] The integration of the Schiff base unit into organotin(IV) carboxylate complexes has proven to be a pivotal development, leading to compounds with enhanced biological properties and increased selectivity. This innovative approach offers promising avenues for targeted therapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and anticancer potential of pyrene-appended Schiff base tin(iv) complexes: experimental and computational insights

Paul,

Khan,

Shaik

et al. 2024

New J. Chem.

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“…Schiff bases are versatile ligands which act as building blocks for various organic substrates. The structural integrity of these ligands allows for the inoculation of different acceptors or donors which can readily form a variety of molecular structures with different coordination numbers and geometries around the metallic ions [ 8 – 10 ]. Tridentate ligands, specially tridentate ONO ligands, have been extensively utilized in coordination chemistry throughout the former few decades [ 11 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

et al. 2022

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Current antimicrobial drug discovery and advancement attempts are aimed to identify new complexes that can work effectively against the infections caused by microbes. The aim of present study was to synthesize new diorganotin(IV) complexes of N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-2-nitrobenzohydrazide (H 2 L 1 ), N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-3-methoxybenzohydrazide (H 2 L 2 ) and N' -((8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-4-methylbenzohydrazide (H 2 L 3 ) Schiff base ligands with formula R 2 SnL 1−3 (where R = Me, Et, Bu and Ph). Various spectral and physico-analytical techniques such as elemental analysis, FT-IR, multinuclear ( 1 H, 13 C, 119 Sn) NMR, HRMS and XRD were utilized to structurally elucidate the prepared compounds. Based on the spectral data, it was concluded that ligands behave in a tridentate manner and coordinates to the central tin atom through ONO donor atoms. Furthermore, the synthesized compounds were examined for in vitro antimicrobial activity against four bacterial and two fungal strains. Among the examined compounds, Ph 2 SnL 1 complex (MIC = 0.0095 µmol/mL) was found to be the most active. To rationalize the preferred mode of interactions of the most active compound, a molecular docking study of compound Ph 2 SnL 1 was executed in the binding site of 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of E. coli and sterol 14-alpha demethylase of C. albicans . Compound Ph 2 SnL 1 inhibits the microbes effectively and it could be an effective and new candidate for the modulation of various infections. Graphical Abstract New diorganotin(IV) complexes ( 4–15 ) were prepared from tridentate Schiff base hydrazones ( 1–3 ). The compounds were examined for in vitro antimicrobial activity. Further, molecular docking study of the most potent compound Ph 2 SnL 1 ( 7 ) was performed against the enzyme 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of E. coli and sterol 14-alpha demethylase of C. albicans . Supplementary Information The online version contains supplementary material avail...

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Organotin (IV) complexes derived from tridentate Schiff base ligands: Synthesis, spectroscopic analysis, antimicrobial and antioxidant activity

Cited by 21 publications

References 57 publications

Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Instigating the in vitro antidiabetic activity of new tridentate Schiff base ligand appended M(II) complexes: From synthesis, structural characterization, quantum computational calculations to molecular docking, and molecular dynamics simulation studies

Synthesis, characterization, and anticancer potential of pyrene-appended Schiff base tin(iv) complexes: experimental and computational insights

Development of new tridentate ligands bearing hydrazone motif and their diorganotin(IV) complexes: Synthesis, spectral, antimicrobial and molecular docking studies

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