Organosilicate-polymer drug delivery systems: controlled release and enhanced mechanical properties

Cypes, Stephen H.; Saltzman, W. Mark; Giannelis, Emmanuel P.

doi:10.1016/s0168-3659(03)00133-0

Cited by 134 publications

(90 citation statements)

References 10 publications

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“…The scanning electron microscopy analysis of spray dried powders showed spherical microparticles with nanoparticles on their surfaces (Müller et al, 2000;Pohlmann et al, 2002;Raffin et al, 2003). In parallel, silica nano and microparticles have been described as drug controlled release carriers prepared by sol-gel processes (Kortesuo et al, 2002;Smirnova et al, 2003), porous hollow silica nanoparticles (Chen et al, 2004) or organosilicate-polymer drug delivery systems (Cypes et al, 2003). Furthermore, silica particles have been studied for the adsolubilization of drugs and other substances on their surfaces, employing cationic or nonionic surfactants (Cherkaoui et al, 1998;Cherkaoui et al, 2000), and for development of powders for inhalation (Kawashima et al, 1998) and nanoparticles for in vitro gene transfer (Kneuer et al, 2000;Sameti et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Beck

Lionzo

Costa

et al. 2008

Braz. J. Chem. Eng.

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-This paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.

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Section: Introductionmentioning

confidence: 99%

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Beck

Lionzo

Costa

et al. 2008

Braz. J. Chem. Eng.

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“…Figure 13 shows the influence of the initial STX amount incorporated in PAA/PMVK carrier on the dynamic release of STX at different media pHs at 23, 44 and 73h of release process, in which these periods correspond to the average intestinal transit times (AITT) [72,73]. From these data, it is revealed that the release dynamic of STX varies following a same trend for all durations and media pHs.…”

Section: Resultsmentioning

confidence: 99%

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

Alghamdi

Alsolami

Saeed

et al. 2018

Designed Monomers and Polymers

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A series of poly(acrylic acid)/poly(methyl vinyl ketone) (PAA/PMVK) blends with different compositions were prepared by the solvent casting method. The miscibility of this pair of polymers was investigated by differential scanning calorimetry(DSC), Fourier transform infra-red (FTIR) and X-Ray diffraction (XRD) techniques. An in-vitro cytotoxicity test of the drug-carrier system via MTT (3-(4,5-demethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed no significant cytotoxic effects at concentrations up to 100 µg· ml−1. The STX/PAA-50 drug carrier systems were also prepared by solvent casting of solutions containing the sulfamethoxazole (STX) used as drug model and PAA/PMVK blend in N.N-dimethylformamide then crosslinked with acidified ethylene glycol. The release dynamic of STX from the prepared hydrogels was investigated in which the diffusion through the polymer matrix, the enhancement of the water solubility of STX, the influence of the initial drug concentration, the pH of the medium, and the effect of the degree of swelling of the polymer matrix on the release dynamic was evaluated. According to the total gastrointestinal transit time estimated by Belzer, the estimate distribution of STX released in the different organs indicated that the performance is obtained with the drug – carrier-system containing equal ratios of polymer and 10 wt% of STX (STX-10/PAA-50).

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“…The value of the diffusion coefficient, D, can be calculated according to the following Equation (10). [59][60][61][62] where l is the thickness of the film and m t , m o , and t are as defined previously.…”

Section: Diffusion Behavior Of Fa Through Fahema Filmsmentioning

confidence: 99%

“…The influence of the total drug content grafted on PHEMA on the FA released is carried out at different pH media during 10 and 24 h of the release process which corresponds to the average intestinal transit time (AITT) [54][55][56][57][58][59][60][61][62][63][64][65] and the results obtained are gathered in Figure 12. As it can be seen from these curve profiles that at any pH medium and at any duration the variation of the FA released vs. the total FA content grafted has practically the same profiles, which dramatically decreased when the total FA grafted on PHEMA increased and reached a minimum at about 15 wt% of FA content, notably those at pH 5 and 7 during 24 h of the release process, except that at pH 1 in which the dynamic release continue to decrease slowly.…”

Section: Effect Of the Fa Content In Fahema Systemmentioning

confidence: 99%

Poly(2-hydroxyethylmethacrylate-graft-folic acid), synthesis, solubility enhancement, and release dynamic of folic acid

Beagan

Aouak

AlJuhaiman

et al. 2016

Designed Monomers and Polymers

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A series of poly (2-hydroxyethylmethacrylate-graft-folic acid) (FAHEMA) systems are synthesized by grafting of folic acid (FA) into poly (2-hydroxyethylmethacrylate) via an esterification reaction. The structure of these copolymers is confirmed by NMR and CHN analyses. The thermal behavior of these materials is characterized by DSC and TGA analyses. The surface morphology of FAHEMA films before and after the release process is examined by the SEM method. The cumulative FA released in different pH media from FAHEMA materials occurred via a retro-esterification reaction at body temperature during 72 h in which the influence of the swelling degree of PHEMA, the FA content and pH media on the dynamic release is widely investigated. The results obtained revealed that the solubility of FA in water deduced from the release process is widely improved compared with literature reports. It is also revealed that the diffusion of water in different pH media through the PHEMA matrix and that of FA through FAHEMA materials perfectly obeyed the Fickian models. It was deduced from the kinetic study that the release performance is obtained with the copolymers containing initially 10 and 20 wt% of FA contents.

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Organosilicate-polymer drug delivery systems: controlled release and enhanced mechanical properties

Cited by 134 publications

References 10 publications

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

Poly(2-hydroxyethylmethacrylate-graft-folic acid), synthesis, solubility enhancement, and release dynamic of folic acid

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