Organophosphorus Pesticides Analysis

Stoytcheva, Margarita; Zlatev, Roumen

doi:10.5772/20892

Cited by 12 publications

(7 citation statements)

References 150 publications

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“…For example, if F. graminearum is suppressed by the application of antagonistic bacteria that are used as BA and/or the application of a species-specific fungicide, still large quantities of other Fusarium species might occur, especially, if they had previously been suppressed by F. graminearum [ 19 , 25 ]. Several microbial strains from Clonostachys Trichoderma Bacillus, Pseudomonas , and Paenibacillus genera have been identified as acting antagonistically to F. graminearum under lab and field [ 19 , 35 , 36 , 37 , 38 ] but, no commercial BA is yet available. An appropriate strategy for discovery and development of BA can only be generated thorough understanding the active principles and mechanism of their action [ 39 , 40 , 41 ].…”

Section: Biocontrolmentioning

confidence: 99%

Fighting Fusarium Pathogens in the Era of Climate Change: A Conceptual Approach

et al. 2020

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Fusarium head blight (FHB) caused by Fusarium pathogens is one of the most devastating fungal diseases of small grain cereals worldwide, substantially reducing yield quality and food safety. Its severity is increasing due to the climate change caused by weather fluctuations. Intensive research on FHB control methods has been initiated more than a decade ago. Since then, the environment has been rapidly changing at regional to global scales due to increasing anthropogenic emissions enhanced fertilizer application and substantial changes in land use. It is known that environmental factors affect both the pathogen virulence as well as plant resistance mechanisms. Changes in CO2 concentration, temperature, and water availability can have positive, neutral, or negative effects on pathogen spread depending on the environmental optima of the pathosystem. Hence, there is a need for studies of plant–pathogen interactions in current and future environmental context. Long-term monitoring data are needed in order to understand the complex nature of plants and its microbiome interactions. We suggest an holobiotic approach, integrating plant phyllosphere microbiome research on the ecological background. This will enable the development of efficient strategies based on ecological know-how to fight Fusarium pathogens and maintain sustainable agricultural systems.

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Section: Biocontrolmentioning

confidence: 99%

Fighting Fusarium Pathogens in the Era of Climate Change: A Conceptual Approach

et al. 2020

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“…Giant corporations, such as BASF and Bayer CropScience, which are key suppliers of plant protection products in the world market, became interested in the production of these preparations. It should be noted that some products are produced only for use in the country of manufacture [ 17 ]. However, none of these biological products are registered for use in Russia.…”

Section: Introductionmentioning

confidence: 99%

Bacillusvelezensis Strains for Protecting Cucumber Plants from Root-Knot Nematode Meloidogyne incognita in a Greenhouse

Асатурова

Bugaeva

Homyak

et al. 2022

Plants

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Meloidogyne incognita Kofoid et White is one of the most dangerous root-knot nematodes in greenhouses. In this study, we evaluated two Bacillus strains (Bacillus velezensis BZR 86 and Bacillus velezensis BZR 277) as promising microbiological agents for protecting cucumber plants from the root-knot nematode M. incognita Kof. The morphological and cultural characteristics and enzymatic activity of the strains have been studied and the optimal conditions for its cultivation have been developed. We have shown the nematicidal activity of these strains against M. incognita. Experiments with the cucumber variety Courage were conducted under greenhouse conditions in 2016–2018. We determined the effect of plant damage with M. incognita to plants on the biometric parameters of underground and aboveground parts of cucumber plants, as well as on the gall formation index and yield. It was found that the treatment of plants with Bacillus strains contributed to an increase in the height of cucumber plants by 7.4–43.1%, an increase in leaf area by 2.7–17.8%, and an increase in root mass by 3.2–16.1% compared with the control plants without treatment. The application of these strains was proved to contribute to an increase in yield by 4.6–45.8% compared to control. Our experiments suggest that the treatment of cucumber plants with two Bacillus strains improved plant health and crop productivity in the greenhouse. B. velezensis BZR 86 and B. velezensis BZR 277 may form the basis for bionematicides to protect cucumber plants from the root-knot nematode M. incognita.

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“…Dithiocarbamates (DTC) have not accidentally been chosen as ligands; in fact, some dithiocarbamato salts have displayed good efficacy as chemo-protectants during cisplatin treatment, decreasing its nephrotoxicity without changing its antineoplastic activity [ 19 ]. Indeed, this class of compounds could diminish the interactions between the metal center and the sulfur-containing biomolecules, which are generally believed to have negative effects on the therapeutic efficacy of platinum-based drugs [ 20 , 21 ]. Unfortunately, the applicability of DTC salts as chemo-protectants is limited by the acute toxicity of free DTC in the body, which biodegrade to different toxic metabolites, such as carbon disulfide, thiourea, and alkyl amines [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, this class of compounds could diminish the interactions between the metal center and the sulfur-containing biomolecules, which are generally believed to have negative effects on the therapeutic efficacy of platinum-based drugs [ 20 , 21 ]. Unfortunately, the applicability of DTC salts as chemo-protectants is limited by the acute toxicity of free DTC in the body, which biodegrade to different toxic metabolites, such as carbon disulfide, thiourea, and alkyl amines [ 21 ]. Nevertheless, when the dithiocarbamates are coordinated to a metal center, the resulting complex is expected to be stable because of the “chelate effect”.…”

Section: Introductionmentioning

confidence: 99%

Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells

et al. 2021

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Malignant tumors have affected the human being since the pharaoh period, but in the last century the incidence of this disease has increased due to a large number of risk factors, including deleterious lifestyle habits (i.e., smoking) and the higher longevity. Many efforts have been spent in the last decades on achieving an early stage diagnosis of cancer, and more effective cures, leading to a decline in age-standardized cancer mortality rates. In the last years, our research groups have developed new metal-based complexes, with the aim to obtain a better selectivity for cancer cells and less side effects than the clinically established reference drug cisplatin. This work is focused on four novel Au(III) and Ru(III) complexes that share the piperidine dithiocarbamato (pipe-DTC) as the ligand, in a different molar ratio. The compounds [AuCl2(pipeDTC)], [Au(pipeDTC)2]Cl, [Ru(pipeDTC)3] and β-[Ru2(pipeDTC)5] have been synthesized and fully characterized by several chemical analyses. We have then investigated their biological properties in two different cell lines, namely, AGS (gastric adenocarcinoma) and HCT116 (colon carcinomas), showing significant differences among the four compounds. First, the two gold-based compounds and β-[Ru2(pipeDTC)5] display IC50 in the µM range, significantly lower than cisplatin. Second, we showed that [AuCl2(pipeDTC)] and β-[Ru2(pipeDTC)5]Cl drive different molecular mechanisms. The first was able to induce the protein level of the DNA damage response factor p53 and the autophagy protein p62, in contrast to the second that induced the ATF4 protein level, but repressed p62 expression. This study highlights that the biological activity of different complexes bringing the same organic ligand depends on the electronic and structural properties of the metal, which are able to fine tune the biological properties, giving us precious information that can help to design more selective anticancer drugs.

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Organophosphorus Pesticides Analysis

Cited by 12 publications

References 150 publications

Fighting Fusarium Pathogens in the Era of Climate Change: A Conceptual Approach

Fighting Fusarium Pathogens in the Era of Climate Change: A Conceptual Approach

Bacillusvelezensis Strains for Protecting Cucumber Plants from Root-Knot Nematode Meloidogyne incognita in a Greenhouse

Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells

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