Organophosphorus compounds. I. Toxicity in domestic animals

Abdelsalam, E. B.

doi:10.1007/bf00570918

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…Recently our lab showed that acute exposure to fipronil [7] or chronic oral exposure to lindane [13], chlorpyriphos [58] and indoxacarb [59] alters the lung histomorphology. Other reports also indicate lung damage following exposure to organophosphate [60], malathion [61] and chlorpyriphos [62]. The histopathological data taken together suggest both doses of fipronil resulted in lung inflammation and damage was more severe when combined with LPS.…”

Section: Discussionmentioning

confidence: 77%

Transcriptome analysis reveals the role of the PCP pathway in fipronil and endotoxin-induced lung damage

et al. 2019

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Section: Discussionmentioning

confidence: 77%

Transcriptome analysis reveals the role of the PCP pathway in fipronil and endotoxin-induced lung damage

et al. 2019

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Inorganic and Organic Poisons

McCaughey¹

2007

Diseases of Sheep

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Respiratory and pulmonary haemodynamic changes during experimental organophosphate poisoning in goats

Bakima

Baudet

Lekeux

et al. 1989

Veterinary Research Communications

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Five French Alpine goats received 2 mg kg-1 of dichlorvos (DDVP) by intravenous injection and 0.15 mg kg-1 of atropine sulphate 5-10 min later. Ventilatory mechanics, gas exchanges, pulmonary haemodynamics and pulmonary vascular resistance (PVR) were measured before treatment, 5 min after DDVP injection and 5 min after atropine injection. Within 2 min of DDVP administration, all the goats showed acute respiratory distress, excitation and slight muscle fasciculations. A post-inspiratory pause was recorded in 3 goats. Hypersecretion of saliva or nasal discharge was not observed. Dynamic compliance and heart rate decreased significantly and total pulmonary resistance, pulmonary artery and wedge pressures increased significantly. On the other hand, minute ventilation, arterial oxygen and carbon dioxide tensions were not significantly altered by DDVP. Atropine treatment reversed all the clinical and functional parameters, with the exception of the central nervous and muscular signs, which disappeared within 12 h. It was concluded that experimental DDVP toxicosis induced changes in the mechanics of breathing and pulmonary haemodynamics associated with diffuse bronchoconstriction and cardiac insufficiency respectively.

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Organophosphorus compounds. I. Toxicity in domestic animals

Abstract: Organophosphorus compounds with various aspects of their modes of action, toxicity and antidotal treatment have been briefly reviewed. Their clinical, pathological and biochemical effects on different species of domestic animals are also described.

Cited by 8 publications

References 21 publications

Transcriptome analysis reveals the role of the PCP pathway in fipronil and endotoxin-induced lung damage

Transcriptome analysis reveals the role of the PCP pathway in fipronil and endotoxin-induced lung damage

Inorganic and Organic Poisons

Respiratory and pulmonary haemodynamic changes during experimental organophosphate poisoning in goats

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