Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years

Jusko, Todd A.; Dries, Michiel A. van den; Pronk, Anjoeka; Shaw, Pamela A.; Guxens, Mònica; Spaan, Suzanne; Jaddoe, Vincent W. V.; Tiemeier, Henning; Longnecker, Matthew P.

doi:10.1289/ehp3024

Cited by 34 publications

(22 citation statements)

References 47 publications

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“…In the Mount Sinai cohort, the Perceptual Reasoning and Full Scale IQ scores were more negatively affected by maternal exposure to OP pesticides in those children whose mothers who had the PON192 QQ genotype. However, no interaction between gestational exposure to OP's during and PON1 genotypes was found traits related to social skills [34] and non-verbal IQ [35].…”

Section: Introductionmentioning

confidence: 78%

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

et al. 2020

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The levels and activity of the enzyme paraoxonase 1 affect the vulnerability to the teratogenic effects of organophosphate pesticides. Mutant mice lacking the gene for paraoxo-nase1 (PON1-/-) are more susceptible to the toxic effects of chlorpyrifos, and were hypothesized to be more vulnerable to social behavior deficits induced by exposure to chlorpyrifos during gestation. Three experiments were performed comparing PON1-/mice to PON1 +/+ mice born to dams treated with 0.5 mg/kg chlorpyrifos or cornoil vehicle on gestational days 12-15. Chlofpyrifos-exposed male PON1-/mouse pups had delayed development of reflexes in in the first experiment. In the second experiment, adult male and female PON1-/mice and the female PON1 +/+ mice all displayed lower social preference than the male vehicle-treated PON1 +/+ mice. The PON1-/mice and the female PON1 +/+ mice displayed lower social preference compared to the PON1 +/+ male mice. Male adult mice that had been exposed in utero to chlorpyrifos showed less conditioned social preference regardless of genotype. In the third study, the delayed reflex development was replicated in male and female PON1-/mice, but chlorpyrifos did not augment this effect. Nest Odor Preference, a test of early social attachment to dam and siblings, was lower in PON1-/mouse pups compared to PON1 +/+ pups. This study shows for the first time that PON1-/mice have a behavioral phenotype that indicates impaired reflex development and social behavior. Chlorpyrifos exposure during gestation tended to augment some of these effects.

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Section: Introductionmentioning

confidence: 78%

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

et al. 2020

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“…At each of the three study visits, urine samples were collected from participants in polypropylene cups and stored until analysis at −20°C (Jusko et al. 2019; Kruithof et al.…”

Section: Methodsmentioning

confidence: 99%

“…2014). Six nonspecific DAPs were measured using gas chromatography coupled with tandem mass spectrometry (GC-MS/MS) at the Institute National de Santé Publique (INSPQ) in Quebec, Canada, with methods described in detail elsewhere (Haines and Murray 2012; Jusko et al. 2019).…”

Section: Methodsmentioning

confidence: 99%

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Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth

Ferguson

Dries

Gaillard

et al. 2019

Environ Health Perspect

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Background:Perturbations in fetal growth may have adverse consequences for childhood and later life health. Organophosphate pesticide (OP) exposure has been associated with reduced birth weight at delivery but results are not consistent. We investigated this question by utilizing ultrasound measures of size in utero in combination with measures from delivery.Methods:Within Generation R, a population-based prospective cohort conducted between 2002 and 2006 in Rotterdam, Netherlands, we measured dialkyl phosphates (DAPs), OP metabolites, in urine samples from early, middle, and late pregnancy and created a subject-specific average to estimate OP exposure (n=784). Ultrasound measures of head circumference, femur length, and estimated fetal weight from middle and late pregnancy and delivery measures were converted to standard deviation scores (SDS). Associations with DAP average were examined in linear mixed effects models that included an interaction term between gestational age at measurement and DAP average to investigate whether the relationship differed over time. Windows of vulnerability to exposure were assessed by modeling urinary DAPs from each visit in relation to growth measurements.Results:A 10-fold increase in average DAPs was associated with a −0.53 SDS decrease in fetal length (95% CI =−0.83, −0.23) and a −0.32 SDS decrease in estimated fetal weight (95% CI =−0.59, −0.04) at 20 weeks of gestation. These differences corresponded to 5% and 6% decreases relative to the mean. Effect estimates were greatest in magnitude for DAP concentrations measured early in pregnancy. Associations between average DAPs and growth measures at delivery were positive but not significant for head circumference and length and were null for weight.Conclusions:Maternal urinary DAPs were associated with decreased fetal weight and length measured during mid-pregnancy, but not at delivery. https://doi.org/10.1289/EHP4858

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Agrochemicals Impact on Ecosystem and Bio-monitoring

Dhananjayan

Jayanthi

Jayakumar³

et al. 2020

Resources Use Efficiency in Agriculture

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Organophosphate Pesticide Metabolite Concentrations in Urine during Pregnancy and Offspring Nonverbal IQ at Age 6 Years

Cited by 34 publications

References 47 publications

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

Developmental and social deficits and enhanced sensitivity to prenatal chlorpyrifos in PON1-/- mouse pups and adults

Organophosphate Pesticide Exposure in Pregnancy in Association with Ultrasound and Delivery Measures of Fetal Growth

Agrochemicals Impact on Ecosystem and Bio-monitoring

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