Organophosphate pesticide exposure and differential genome-wide DNA methylation

Paul, Kimberly C.; Chuang, Yen; Cockburn, Myles; Bronstein, Jeff M.; Horvath, Steve; Ritz, Beate

doi:10.1016/j.scitotenv.2018.07.143

Cited by 60 publications

(44 citation statements)

References 33 publications

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“…Organic micropollulants are contaminants that originate from human activity and persist in soil, surface and groundwater systems. Organic micropollulants include pesticides, pharmaceutical drugs, industrial chemicals and personal care products, and can have serious environmental and health effects including infertility and reproductive mutations in aquatic organisms, and neurological diseases and cancer in humans . Current extraction methods include bioremediation (the use of microorganisms to consume pollutants), physical remediation (clays, activated carbon, zeolites and surfactants) and chemical remediation (oxidation, UV treatment and supercritical extraction) .…”

Section: Sequestration Of Organic Micropollutantsmentioning

confidence: 99%

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Polymer sequestrants for biological and environmental applications

Archer

Hall

Thompson

et al. 2019

Polymer International

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Toxic contaminates have profound consequences on both health and the environment. Consequently, effective approaches for addressing the effects of these toxicants are paramount. Here, we review recent progress in developing polymeric sequestrants for biological toxins, heavy metals and organic micropollutants. Polymers have several advantages as sequestration materials, including relatively low cost and high affinity for target compounds. As a result a number of polymer-based toxin-mitigation applications have been investigated. Naturally occurring toxins may be neutralized with polymers capable of binding and eliminating them from the body. Heavy metal contamination from mining operations, energy and industrial sources may also be mitigated with appropriate chelating polymers, both for environmental remediation and in chelation therapy for metal poisoning. Micropollutants such as pesticides from agriculture and polycyclic aromatic hydrocarbons from combustion processes may also be isolated using polymeric materials. Each of these applications illustrates the capabilities of polymers for eliminating toxic contaminants, thereby facilitating greater health and sustainability.

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Section: Sequestration Of Organic Micropollutantsmentioning

confidence: 99%

“…As a result, food safety and water purity are compromised . Studies have linked pesticide exposure to the development of paralysis, Parkinson's disease and lung cancer . Consequently, the removal of pesticides from drinking water is a heavily researched endeavor .…”

Section: Sequestration Of Organic Micropollutantsmentioning

confidence: 99%

Polymer sequestrants for biological and environmental applications

Archer

Hall

Thompson

et al. 2019

Polymer International

View full text Add to dashboard Cite

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“…These findings are provocative, suggesting stronger associations when composite exposures and their possible synergism are considered. In addition, biomarkers of long-term and lifelong environmental exposures are being developed, such as blood methylation profiles for long-term organophosphate exposures [88]. Further, some major scientific and technological advances that inform the external assessment of the exposome have been made [91,92], including geographic information systems, remote sensing, global positioning system and geolocation technologies, portable and personal sensing, including smartphone-based sensors and self-reported questionnaire assessments relying on Internet-based platforms.…”

Section: A Life-long and Exposome Approach To Pd Etiological Researchmentioning

confidence: 99%

The Search for Environmental Causes of Parkinson’s Disease: Moving Forward

Chen

Ritz

2018

JPD

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It is widely believed that environmental exposures contribute to the vast majority of late-onset sporadic Parkinson's disease (PD), alone or via interactions with genetic factors. The search for environmental causes of PD has however been hampered by lack of understanding the prodromal phase of PD development and the difficulties in exposure assessment during this prolonged period. On the other hand, the existence of this prodromal period, along with an increasingly better understanding of PD prodromal symptoms, provides an exciting opportunity to identify environmental factors that initiate PD pathogenesis and/or modify its progression. For prevention efforts, this prodromal stage is of a major interest. Targeting factors that enter the body via the nose or gut has become even more important since the discovery of ␣-synuclein aggregates in the enteric and olfactory nervous systems. In this paper, we speculate about novel research hypotheses and approaches that may help us better define the role of environment in PD etiology, especially during its extended and complex prodromal phase.

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“…First, they have been used for discovery. Using these arrays, literally thousands of studies describing the relationship of methylation to illnesses, such as diabetes and heart disease, or to environmental exposures/consumption of substances such as cigarettes, alcohol, and pesticides have been conducted [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Importantly, the findings from many of these studies have been subsequently replicated in cohorts of other ancestries thus ensuring the generalizability of the findings across ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Array-Based Epigenetic Aging Indices May Be Racially Biased

Philibert

Beach

Lei

et al. 2020

Genes

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Epigenetic aging (EA) indices are frequently used as predictors of mortality and other important health outcomes. However, each of the commonly used array-based indices has significant heritable components which could tag ethnicity and potentially confound comparisons across racial and ethnic groups. To determine if this was possible, we examined the relationship of DNA methylation in cord blood from 203 newborns (112 African American (AA) and 91 White) at the 513 probes from the Levine PhenoAge Epigenetic Aging index to ethnicity. Then, we examined all sites significantly associated with race in the newborn sample to determine if they were also associated with an index of ethnic genetic heritage in a cohort of 505 AA adults. After Bonferroni correction, methylation at 50 CpG sites was significantly associated with ethnicity in the newborn cohort. The five most significant sites predicted ancestry with a receiver operator characteristic area under the curve of 0.97. Examination of the top 50 sites in the AA adult cohort showed that methylation status at 11 of those sites was also associated with percentage European ancestry. We conclude that the Levine PhenoAge Index is influenced by cryptic ethnic-specific genetic influences. This influence may extend to similarly constructed EA indices and bias cross-race comparisons.

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Organophosphate pesticide exposure and differential genome-wide DNA methylation

Cited by 60 publications

References 33 publications

Polymer sequestrants for biological and environmental applications

Polymer sequestrants for biological and environmental applications

The Search for Environmental Causes of Parkinson’s Disease: Moving Forward

Array-Based Epigenetic Aging Indices May Be Racially Biased

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