Organophosphate insecticide exposure and telomere length in U.S. adults

Ock, Jeongwon; Kim, Jung-Hoon; Choi, Yoon-Hyeong

doi:10.1016/j.scitotenv.2019.135990

Cited by 23 publications

(11 citation statements)

References 56 publications

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“…Telomere attrition is a natural cellular process that occurs over time; however, certain factors can accelerate their shortening, such as chronic stress [28], inflammatory processes and lack of physical activity [29], polyunsaturated fatty acid intake [30], smoking [31], environmental pollutants [32], NO2 [33], and organophosphate insecticides [34]. All these factors can generate oxidative stress at the cellular level, leading to cellular aging [35][36][37].…”

Section: Telomere Length: Normal and Accelerated Attritionmentioning

confidence: 99%

Physical performance and telomere length in older adults

Martínez-Ezquerro,

Ortiz-Ramírez,

García-delaTorre

et al. 2023

Preprint

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BackgroundThe fast-paced aging demographic prompts studying risk factors and markers that could predict healthy aging. Telomere length shows promise for assessing a broad spectrum of aging-related phenotypes.Aim of the studyTo assess the association between physical performance and telomere length in Mexican older adults.MethodsIn this observational cross-sectional study, we recruited 323 older adults affiliated with the Instituto Mexicano del Seguro Social (IMSS) and members of the “Cohort of Obesity, Sarcopenia, and Frailty of Older Mexican Adults’’ (COSFOMA). To assess physical performance, we used the Short Physical Performance Battery (SPPB) and stratified individuals into two groups according to their SPPB score into low ≤7 (L-SPPB) and high >7 (H-SPPB). Absolute telomere length (aTL) was determined by using qPCR. Next, we classified individuals according to their aTL into short ≤4.22 kb (S-TL) and long >4.22 kb (L-TL). For both SPPB and aTL categories, we calculated the mean and adjusted mean by sex, age, marital status, education, remunerated work, smoking, drinking, cognitive decline, depression, and polypharmacy with 95% CI, including the lower and upper CI (LCImeanUCI). We estimated the effect size between physical performance and telomere length with Cohen’s d for unequal group sizes. Also, we calculated the odds ratio with 95% confidence intervals, including the lower and upper CI (LCIORUCI) for physical performance according to telomere length categories.ResultsParticipants in the low physical performance category had significantly shorter telomeres (4.14.44.7mean and3.54.04.5kb adjusted mean, p<0.001), in opposition to the high physical performance category (score >7) with longer telomeres (5.55.75.9mean and4.75.35.8kb adjusted mean, p<0.001), with a medium-to-high telomere length effect size (d= 0.762). Finally, the odds of being classified in the low physical activity category increased2.13.66.1times per kb of telomere (adjOR1.73.36.3, p<0.001) compared to the high physical activity group (p<0.001).ConclusionDecreased physical functioning is associated with lower telomere length. Absolute telomere length (aTL) as a possible biomarker for differential diagnosis of healthy and unhealthy aging should be explored further.

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Section: Telomere Length: Normal and Accelerated Attritionmentioning

confidence: 99%

Physical performance and telomere length in older adults

Martínez-Ezquerro,

Ortiz-Ramírez,

García-delaTorre

et al. 2023

Preprint

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“…Previous epidemiological studies have found PFAS exposures are associated with altered TL in humans; perfluorooctanoic acid (PFOA) has been associated with telomere shortening [ 18 ] and perfluorooctane sulfonic acid (PFOS) has been associated with telomere lengthening [ 17 ]. To our knowledge, no human studies have examined associations between OPFRs and TL, although one study of chemically similar organophosphate insecticides found associations with altered TL, with the direction of effect depending on the insecticide in question [ 93 ]. As a possible intermediary between exposure and disease, TL serves as a biomarker of effect for assessing the potential impacts of environmental exposures on human health.…”

Section: Introductionmentioning

confidence: 99%

Associations between polyfluoroalkyl substance and organophosphate flame retardant exposures and telomere length in a cohort of women firefighters and office workers in San Francisco

et al. 2021

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Background Environmental chemical exposures can affect telomere length, which in turn has been associated with adverse health outcomes including cancer. Firefighters are occupationally exposed to many hazardous chemicals and have higher rates of certain cancers. As a potential biomarker of effect, we assessed associations between chemical exposures and telomere length in women firefighters and office workers from San Francisco, CA. Methods We measured serum concentrations of polyfluoroalkyl substances (PFAS), urinary metabolites of flame retardants, including organophosphate flame retardants (OPFRs), and telomere length in peripheral blood leukocytes in women firefighters (N = 84) and office workers (N = 79) who participated in the 2014–15 Women Workers Biomonitoring Collaborative. Multiple linear regression models were used to assess associations between chemical exposures and telomere length. Results Regression results revealed significant positive associations between perfluorooctanoic acid (PFOA) and telomere length and perfluorooctanesulfonic acid (PFOS) and telomere length among the whole cohort. Models stratified by occupation showed stronger and more significant associations among firefighters as compared to office workers. Among firefighters in models adjusted for age, we found positive associations between telomere length and log-transformed PFOA (β (95%CI) = 0.57(0.12, 1.02)), PFOS (0.44 (0.05, 0.83)), and perfluorodecanoic acid (PFDA) (0.43 (0.02, 0.84)). Modeling PFAS as categories of exposure showed significant associations between perfluorononanoic acid (PFNA) and telomere length among firefighters. Significant associations between OPFR metabolites and telomere length were seen for bis (1,3-dichloro-2-propyl) phosphate (BDCPP) and telomere length among office workers (0.21(0.03, 0.40)) and bis (2-chloroethyl) phosphate (BCEP) and telomere length among firefighters (− 0.14(− 0.28, − 0.01)). For OPFRs, the difference in the direction of effect by occupational group may be due to the disparate detection frequencies and concentrations of exposure between the two groups and/or potential unmeasured confounding. Conclusion Our findings suggest positive associations between PFAS and telomere length in women workers, with larger effects seen among firefighters as compared to office workers. The OPFR metabolites BDCPP and BCEP are also associated with telomere length in firefighters and office workers. Associations between chemical exposures and telomere length reported here and by others suggest mechanisms by which these chemicals may affect carcinogenesis and other adverse health outcomes.

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“…Despite all actions aimed to sustainable agriculture, environmental problems are increasing due to the increasing use of agrochemicals and the high amount of the produced wastes and heavy metals resulting in adverse effects on human health affecting as well environment quality and food-chain [8][9][10][11][12][13][14]. Therefore, it is necessary to seek for alternatives of agrochemical products and take further action to explore the potential of agricultural wastes [15].…”

Section: Introductionmentioning

confidence: 99%