Organometallic Oxidative Addition Complexes for S-Arylation of Free Cysteines
Hayden R. Montgomery,
Alexander M. Spokoyny,
Heather D. Maynard
Abstract:Development of bioconjugation strategies to efficiently modify biomolecules is of key importance for fundamental and translational scientific studies. Cysteine S-arylation is an approach which is becoming more popular due to generally rapid kinetics and high chemoselectivity, as well as the strong covalently bonded S-aryl linkage created in these processes. Organometallic approaches to cysteine S-arylation have been explored that feature many advantages compared to their more traditional organic counterparts. … Show more
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