Organometallic cluster analogues of tamoxifen: Synthesis and biochemical assay

Chan, Kiat Hwa; Leong, Weng Kee; Jaouen, Gérard; Leclerq, Laurence; Top, Siden; Vessières, Anne

doi:10.1016/j.jorganchem.2005.08.041

Cited by 16 publications

(10 citation statements)

References 33 publications

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“…Thus, thiol, which is a soft base 40 – 42 and a good σ -donor and back π acceptor, has a strong interaction between Os and CO. This observation is consistent with the reported crystal structures of Os 3 species that the CO ligands trans to the thiol group are notably shorter than those in hydroxylated and carboxylated triosmium species 20 , 37 , 43 , 44 . Thus, a higher stretching frequency for the totally symmetric mode for carboxylated triosmium is always reported.…”

Section: Resultssupporting

confidence: 92%

Geometrically encoded SERS nanobarcodes for the logical detection of nasopharyngeal carcinoma-related progression biomarkers

et al. 2021

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The limited availability of nasopharyngeal carcinoma-related progression biomarker array kits that offer physicians comprehensive information is disadvantageous for monitoring cancer progression. To develop a biomarker array kit, systematic identification and differentiation of a large number of distinct molecular surface-enhanced Raman scattering (SERS) reporters with high spectral temporal resolution is a major challenge. To address this unmet need, we use the chemistry of metal carbonyls to construct a series of unique SERS reporters with the potential to provide logical and highly multiplex information during testing. In this study, we report that geometric control over metal carbonyls on nanotags can produce 14 distinct barcodes that can be decoded unambiguously using commercial Raman spectroscopy. These metal carbonyl nanobarcodes are tested on human blood samples and show strong sensitivity (0.07 ng/mL limit of detection, average CV of 6.1% and >92% degree of recovery) and multiplexing capabilities for MMPs.

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Section: Resultssupporting

confidence: 92%

Geometrically encoded SERS nanobarcodes for the logical detection of nasopharyngeal carcinoma-related progression biomarkers

et al. 2021

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“…However, the angle of the trajectory is not a "physical" parameter and we always find for these four values of α similar values for s and q as those given in Table 4. The theoretical anomalies predicted by Han (2009a) for a diamond-shaped central caustic are similar to ours (see his Fig. 3) and we can conclude that we have made the first experimental detection of this predicted effect.…”

Section: Study Of Deviations Due To Caustic Crossingsupporting

confidence: 88%

“…Our central caustic looks symmetric (diamond shape) and our models are degenerate modulo π 2 . The excess magnification for this kind of caustic (see Han 2009a) is also symmetric with respect to a rotation of π 2 . However, the angle of the trajectory is not a "physical" parameter and we always find for these four values of α similar values for s and q as those given in Table 4.…”

Section: Study Of Deviations Due To Caustic Crossingmentioning

confidence: 78%

A brown dwarf orbiting an M-dwarf: MOA 2009–BLG–411L

Bachelet¹,

Fouqué²,

Han³

et al. 2012

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Context. Caustic crossing is the clearest signature of binary lenses in microlensing. In the present context, this signature is diluted by the large source star but a detailed analysis has allowed the companion signal to be extracted. Aims. MOA 2009-BLG-411 was detected on August 5, 2009 by the MOA-Collaboration. Alerted as a high-magnification event, it was sensitive to planets. Suspected anomalies in the light curve were not confirmed by a real-time model, but further analysis revealed small deviations from a single lens extended source fit. Methods. Thanks to observations by all the collaborations, this event was well monitored. We first decided to characterize the source star properties by using a more refined method than the classical one: we measure the interstellar absorption along the line of sight in five different passbands (VIJHK). Secondly, we model the lightcurve by using the standard technique: make (s, q, α) grids to look for local minima and refine the results by using a downhill method (Markov chain Monte Carlo). Finally, we use a Galactic model to estimate the physical properties of the lens components. Results. We find that the source star is a giant G star with radius 9 R . The grid search gives two local minima, which correspond to the theoretical degeneracy s ≡ s −1 . We find that the lens is composed of a brown dwarf secondary of mass M S = 0.05 M orbiting a primary M-star of mass M P = 0.18 M . We also reveal a new mass-ratio degeneracy for the central caustics of close binaries. Conclusions. As far as we are aware, this is the first detection using the microlensing technique of a binary system in our Galaxy composed of an M-star and a brown dwarf.

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“…(159) The organometallic moiety was found to increase the lipophilicity and reduced the affinity, via steric hindrance, for the estrogen receptor, but no cytotoxicity studies were carried out on the compounds.…”

Section: Organometallic Osmium Half-sandwich Complexesmentioning

confidence: 99%