Organometallic binuclear Pd(II) complex: Synthesis, crystal structure and in-vitro antitumor activity study

Gong, Guidong; Gao, Xingxing; Xian-Hong, YU; Zhang, Huiya; Yang, Jiaqi; Zhang, Zhonghui; Du, Guoyuan; Cao, Yuan; Zhao, Gang

doi:10.1016/j.inoche.2019.05.017

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…As shown in Figure 4 C-E, the fluorescence intensity of tumors treated with DIR-labeled FCP/HA (referred to FCP-DIR/HA) was significantly higher than the tumors treated with DIR alone. This result suggested that HA contained nanoPDT was selectively taken up into tumor tissues, which was caused by the specific binding of HA and CD44 in the tumor tissue 27 , 31 . These results indicated that the HA-containing nanoPDT could help transport drugs to the tumor site in vivo .…”

Section: Resultsmentioning

confidence: 93%

“…Moreover, due to the switchability of the ligands, the acetic acid coordinated-FCP can form micelles with macromolecules containing carboxyl groups like HA 25 . Besides, HA is well-known to specifically bind to overexpressed CD44 on tumor cells 13 , 24 , facilitating an active targeting ability to tumors (Figure 1 C) 6 , 27 , 28 . Our results showed that the coordination between HA and FCP played a key role in the nanomicellar formation mechanism.…”

Section: Introductionmentioning

confidence: 99%

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Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy

Gong¹,

Pan²,

He³

et al. 2022

Theranostics

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Rationale : The combination of photosensitizers, oxygen supply agents, and adjuvant therapy drugs in a single nano-drug delivery system for photodynamic therapy (PDT) has been showing great promises to overcome the inherent challenges of PDT for tumor treatment. However, the complicated preparation of integrating multiple components hampers their further developments. Here, we describe a self-assembly nanomicelle with rationally designed building blocks, which shows a high efficiency of synergistic chemo-photodynamic therapy in the animal modal. Methods : The nanomicelle was prepared by a coordination-driven self-assembly based on a rationally designed ferrocene cyclopalladated compound coupled with photosensitizers and hyaluronic acid (referred to as FCP-Tph/HA). The morphology, targeting drug delivery, pharmacokinetics, hemolysis, and multimodal synergistic therapy of FCP-Tph/HA were investigated. Results : The formation of nanomicelles presents a low hemolysis rate and a prolonged blood circulation time. FCP-Tph/HA possesses an enhanced antitumor effect in vitro through the specific binding of HA to CD44 and combining chemotherapy with oxygen self-supplying PDT. Simultaneously, the nanomicelle facilitates a significantly improved antitumor efficacy (>90% tumor regression) on a breast cancer model in vivo . Conclusion : Our results present a modular self-assembled nanomicellar platform with synergistic chemo-photodynamic therapy for challenging PDT-based tumor treatment.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy

Gong¹,

Pan²,

He³

et al. 2022

Theranostics

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“…It is noteworthy that, in contrast to traditional chiral chemicals that possess one or more stereogenic centers, planar chiral molecules have seldom been studied as pesticides or human drugs. − Obstacles might exist in the preparation of such planar chiral molecules. We have taken advantage of the organocatalytic methods that were previously developed in our group for the synthesis of the enantio-pure planar chiral molecules containing α-aminophosphonate structures …”

Section: Introductionmentioning

confidence: 99%

Synthesis of Planar Chiral Compounds Containing α-Amino Phosphonates for Antiplant Virus Applications against Potato Virus Y

Deng,

Cai,

Jin

et al. 2024

J. Agric. Food Chem.

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An unprecedented study of the application of planar chiral compounds in antiviral pesticide development is reported. A class of multifunctional planar chiral ferrocene derivatives bearing α-amino phosphonate moieties was synthesized. These compounds, exhibiting superior optical purities, were subsequently subjected to antiviral evaluations against the notable plant pathogen potato virus Y (PVY). The influence of the absolute configurations of the planar chiral compounds on their antiviral bioactivities was significant. A number of these enantiomerically enriched planar chiral molecules demonstrated superior anti-PVY activities. Specifically, compound (S p, R)-9n displayed extraordinary curative activities against PVY, with a 50% maximal effective concentration (EC50) of 216.11 μg/mL, surpassing the efficacy of ningnanmycin (NNM, 272.74 μg/mL). The protective activities of compound (S p, R)-9n had an EC50 value of 152.78 μg/mL, which was better than that of NNM (413.22 μg/mL). The molecular docking and defense enzyme activity tests were carried out using the planar chiral molecules bearing different absolute configurations to investigate the mechanism of their antiviral activities against PVY. (S p , R)-9n, (S p , R)-9o, and NMM all showed stronger affinities to the PVY-CP than the (R p , S)-9n. Investigations into the mechanisms revealed that the planar chiral configurations of the compounds played pivotal roles in the interactions between the PVY-CP molecules and could augment the activities of the defense enzymes. This study contributes substantial insights into the role of planar chirality in defending plants against viral infections.

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Heterometallic Ferrocenyl Complexes and Their Application in the Treatment of Cancer

Lord¹,

Hofmann²,

Stringer³

2022

Encyclopedia of Inorganic and Bioinorganic Chemistry

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Ferrocene, a stable 18‐electron metallocene, has been readily modified to include other functionalities by reactions such as Friedel–Crafts and Mannich. While ferrocene and its derivatives have many applications, for example, as fuel additives and materials chemistry, they have been heavily researched in the past three decades for their medicinal applications; namely, tamoxifen, a well‐known breast cancer drug, has been modified with ferrocene (ferrocifen) to improve breast cancer selectivity, and chloroquine, an antimalarial drug, was modified with ferrocene to improve its activity in chloroquine‐resistant malarial strains. In these two molecules, ferrocene imparts a metal‐specific effect, enhancing the therapeutic potential of these complexes. Ferrocifen and ferroquine are currently in phase II clinical trials and preclinical evaluation, respectively. No other ferrocene‐containing complexes have reached clinical trial stages. One strategy that could fast‐track these complexes to an advanced stage is to develop heterometallic complexes, as they often exhibit enhanced pharmacological properties and have different biological targets compared to their homometallic/mononuclear counterparts. In this article, we have highlighted the area of heterometallic ferrocenyl complexes and their applications in the treatment of cancer and look at the most promising complexes to date.

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Organometallic binuclear Pd(II) complex: Synthesis, crystal structure and in-vitro antitumor activity study

Cited by 9 publications

References 21 publications

Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy

Self-assembly of nanomicelles with rationally designed multifunctional building blocks for synergistic chemo-photodynamic therapy

Synthesis of Planar Chiral Compounds Containing α-Amino Phosphonates for Antiplant Virus Applications against Potato Virus Y

Heterometallic Ferrocenyl Complexes and Their Application in the Treatment of Cancer

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