Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium

Abstract

Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.

No barrier breakdown between human and cattle schistosome species in the Senegal River Basin in the face of hybridisation

“…Adult S. bovis worms were collected in Richard Toll (2010) from four cows (64 samples in total) and extracted by Webster et al (2013). The eggs from Mali were collected in Kalabogou and Kaladagan, and obtained through a previous study by Willeman Stecher et al (2017).…”

Persistance de la schistosomiase urinaire en zones endémiques soumises aux traitements de masse répétés au Mali

“…Les zones soudaniennes et nord soudaniennes sont moins touchées avec une prévalence de 10% (Traore et al, 2007). Actuellement dans la région de Ségou des études ont données une prévalence de 79,8% pour S. haematobium et 13,2% pour S. mansoni (Stecher et al, 2017).…”