Organoids as preclinical models to improve intraperitoneal chemotherapy effectiveness for colorectal cancer patients with peritoneal metastases: Preclinical models to improve HIPEC

Roy, Pétronille; Canet-Jourdan, Charlotte; Annereau, Maxime; Zajac, Olivier; Gelli, Maximiliano; Broutin, Sophie; Mercier, Lionel; Paci, Angélo; Lemare, François; Ducreux, Michel; Élias, Dominique; Malka, David; Boige, Valérie; Goèré, Diane; Jaulin, Fanny

doi:10.1016/j.ijpharm.2017.07.084

Cited by 22 publications

(8 citation statements)

References 43 publications

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“…One exciting potential use of patient-derived enteroids is to evaluate the effectiveness of personalized medicine, such as precision chemotherapy for cancer patients. Roy et al successfully evaluated the effects of Mitomycin-C, 5-Fluorouracil (5-FU), Irinotecan, Oxaliplatin, Doxorubicin, and Paclitaxel on peritoneal metastases using enteroids (Roy et al, 2017 ). Enteroids have also been used to model various intestinal physiology and disease processes (Table 2 ).…”

Section: Lessons Learned From Studies Of Other Enteropathogensmentioning

confidence: 99%

Organoid and Enteroid Modeling of Salmonella Infection

Yin

Zhou

2018

Front. Cell. Infect. Microbiol.

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Salmonella are Gram-negative rod-shaped facultative anaerobic bacteria that are comprised of over 2,000 serovars. They cause gastroenteritis (salmonellosis) with headache, abdominal pain and diarrhea clinical symptoms. Salmonellosis brings a heavy burden for the public health in both developing and developed countries. Antibiotics are usually effective in treating the infected patients with severe gastroenteritis, although antibiotic resistance is on the rise. Understanding the molecular mechanisms of Salmonella infection is vital to combat the disease. In vitro immortalized 2-D cell lines, ex vivo tissues/organs and several animal models have been successfully utilized to study Salmonella infections. Although these infection models have contributed to uncovering the molecular virulence mechanisms, some intrinsic shortcomings have limited their wider applications. Notably, cell lines only contain a single cell type, which cannot reproduce some of the hallmarks of natural infections. While ex vivo tissues/organs alleviate some of these concerns, they are more difficult to maintain, in particular for long term experiments. In addition, non-human animal models are known to reflect only part of the human disease process. Enteroids and induced intestinal organoids are emerging as effective infection models due to their closeness in mimicking the infected tissues/organs. Induced intestinal organoids are derived from iPSCs and contain mesenchymal cells whereas enteroids are derive from intestinal stem cells and are comprised of epithelial cells only. Both enteroids and induced intestinal organoids mimic the villus and crypt domains comparable to the architectures of the in vivo intestine. We review here that enteroids and induced intestinal organoids are emerging as desired infection models to study bacterial-host interactions of Salmonella.

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Section: Lessons Learned From Studies Of Other Enteropathogensmentioning

confidence: 99%

Organoid and Enteroid Modeling of Salmonella Infection

Yin

Zhou

2018

Front. Cell. Infect. Microbiol.

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“…Adequate comparative clinical studies will be difficult to perform. A more representative in-vitro model of peritoneal metastases of ovarian cancer with tumor-derived organoids (80,81) may eventually contribute to determining the role of hyperthermia in intraoperative intraperitoneal chemotherapy with taxanes.…”

Section: Resultsmentioning

confidence: 99%

Hyperthermia During Intraperitoneal Chemotherapy With Paclitaxel or Docetaxel for Ovarian Cancer: Is There Any Benefit?

et al. 2020

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“…The use of organoids to study peritoneal metastases is far behind that of other cancer systems. Only a few studies have recently been reported, usually involving very few patients and/or organoids that were generated following transplantation of human biopsies in mice [ 136 , 137 , 138 ]. Furthermore, in some cases the so-called organoids were in fact short-lasting primary heterogenous cultures from ovarian or gastric ascites-derived metastases [ 139 , 140 , 141 ].…”

Section: Organoids As a Platform For Screening Assaysmentioning

confidence: 99%

Organoids and Colorectal Cancer

Barbáchano

Fernández‐Barral

Bustamante-Madrid

et al. 2021

Cancers

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Organoids were first established as a three-dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC) by allowing the circumvention of classical problems and limitations, such as the impossibility of long-term culture of normal intestinal epithelial cells and the lack of good animal models for CRC. In this review, we describe the features and current knowledge of intestinal organoids and how they are largely contributing to our better understanding of intestinal cell biology and CRC genetics. Moreover, recent data show that organoids are appropriate systems for antitumoral drug testing and for the personalized treatment of CRC patients.

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Organoids as preclinical models to improve intraperitoneal chemotherapy effectiveness for colorectal cancer patients with peritoneal metastases: Preclinical models to improve HIPEC

Cited by 22 publications

References 43 publications

Organoid and Enteroid Modeling of Salmonella Infection

Organoid and Enteroid Modeling of Salmonella Infection

Hyperthermia During Intraperitoneal Chemotherapy With Paclitaxel or Docetaxel for Ovarian Cancer: Is There Any Benefit?

Organoids and Colorectal Cancer

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