Organohalogenated contaminants in white-tailed eagle (Haliaeetus albicilla) nestlings: An assessment of relationships to immunoglobulin levels, telomeres and oxidative stress

Sletten, Silja; Bourgeon, Sophie; Bårdsen, Bård‐Jørgen; Herzke, Dorte; Criscuolo, François; Massemin, Sylvie; Zahn, Sandrine; Johnsen, Trond Vidar; Bustnes, Jan Ove

doi:10.1016/j.scitotenv.2015.08.123

Cited by 58 publications

(47 citation statements)

References 53 publications

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“…Thus, this work contributes at filling the gap of knowledge about the potential effects of environmental contaminants on telomere length in wildlife. Contrary to our results from the longitudinal approach, PFASs did not predict telomere length in white-tailed eagle (Haliaeetus albicilla) chicks (Sletten et al, 2016). However, this study did not investigate the relationships between contaminants and telomere dynamics, but rather used a cross-sectional approach (i.e.…”

Section: Discussioncontrasting

confidence: 68%

“…Only three studies have studied the associations between contaminants and telomere length in free-ranging vertebrates (Blévin et al, 2016;Sletten et al, 2016;Stauffer et al, 2017). Thus, this work contributes at filling the gap of knowledge about the potential effects of environmental contaminants on telomere length in wildlife.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is still very few information regarding the effects of contaminants on absolute telomere length in free-living animals and no studies have been conducted so far on telomere dynamics, with a longitudinal approach. To the best of our knowledge, a single study has investigated the influence of PFASs on absolute telomere length (with a cross-sectional approach) in free-living birds but did not report any significant relationships (Sletten et al, 2016). Because of this link with survival and environmental stressors, measuring the effect of specific compounds on telomere length and telomere dynamics appear promising to better assess their impact on wildlife (Bateson, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Perfluorinated substances and telomeres in an Arctic seabird: Cross-sectional and longitudinal approaches

Blévin

Angelier

Tartu

et al. 2017

Environmental Pollution

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Telomeres are non-coding DNA repeats located at the termini of eukaryotic chromosomes, regulated by dynamic processes balancing shortening and maintenance. Despite a mechanism to slow-down telomere shortening, cell division leads to progressive attrition of chromosomes, leading to the onset of cellular senescence or apoptosis. However, telomere restoration based on telomerase activity is the primary mechanism for telomere maintenance. Telomere length is associated to health and survival and can be impacted by a broad panel of environmental factors. However, the effect of contaminants on telomeres is poorly known for living organisms. The aim of this study was to investigate relationships between some poly- and perfluoroalkyl substances (PFASs), body condition and telomere length by using both a cross-sectional and longitudinal approach in adult breeding Black-legged kittiwakes (Rissa tridactyla) from Svalbard. First, we examined the associations between absolute telomere length and PFASs contamination in a given year (cross-sectional approach). Second, we investigated the relationships between telomere dynamics and PFASs contamination within a two years' time frame (longitudinal approach). Our results did not show any significant relationships of PFASs and body condition with absolute telomere length in a given year. Surprisingly, we found a positive and significant relationship between PFASs and telomere dynamics in both sexes with elongated telomere in birds bearing the highest concentrations of PFASs. Our study underlines (i) the need to investigate PFAS effects on telomere dynamics with a longitudinal approach and (ii) a potential positive effect of these contaminants on telomere length, with the most contaminated birds showing the slowest rate of telomere shortening or even displaying elongated ones. Our study is the first to report a relationship between PFASs and telomere length in free-living vertebrates. A possible underlying mechanism and other potential confounding factors are discussed.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Perfluorinated substances and telomeres in an Arctic seabird: Cross-sectional and longitudinal approaches

Blévin

Angelier

Tartu

et al. 2017

Environmental Pollution

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“…Nevertheless, these mechanisms are part of the mosaic target for phenotypic selection and environmental effects. Stress and physiological perturbations due to single, specific environmental contaminants (such as biomagnifying organohalogenated compounds) have not been proven to correlate with telomere length . However, the summed effect of the urban versus the rural environment has telomere‐eroding effects, as demonstrated in a cross‐fostering experiment in great tits (using qPCR) .…”

Section: Telomere Regulation and Dynamics: Telomerase And Other Mechamentioning

confidence: 99%

“…Stress and physiological perturbations due to single, specific environmental contaminants (such as biomagnifying organohalogenated compounds) have not been proven to correlate with telomere length. 149 However, the summed effect of the urban versus the rural environment has telomere-eroding effects, as demonstrated in a cross-fostering experiment in great tits (using qPCR). 150 Likewise, experimental manipulation of traffic noise showed that telomere length eroded under elevated noise levels without noise having an effect on growth or fledging success (using qPCR).…”

Section: Figure 6 Relationships Between Mother's Age and The Mean Eamentioning

confidence: 99%

Evolutionary ecology of telomeres: a review

Olsson

Wapstra

Friesen

2017

Annals of the New York Academy of Sciences

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Telomere-induced selection could take place if telomere-associated disease risk shortens reproductive life span and differently reduces relative fitness among individuals. Some of these diseases first appear before reproductive senescence and could thus influence ongoing selection. We ask whether we can estimate the components of the breeder's equation for telomeres, in which the response to selection (R, by definition "evolution") is the product of ongoing selection (S) and heritability (h 2 ). However, telomere inheritance is a conundrum: in quantitative genetics, traits can usually be allocated to categories with relatively high or low heritability, depending on their association with relative fitness. Telomere traits, however, show wide variation in heritability from zero to one, across taxa, gender, ethnicity, age, and disease status. In spite of this, there is divergence in telomere length among populations, supporting past and ongoing telomere evolution. Rates of telomere attrition and elongation vary among taxa with some, but not complete, taxonomic coherence. For example, telomerase is commonly referred to as "restricted to the germ line in mammals," but inbred mice and beavers have telomerase upregulation in somatic tissue, as do many ectotherms. These observations provoke a simplistic understanding of telomere evolutionary biology-clearly much is yet to be discovered.

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Profiling research on PFAS in wildlife: Systematic evidence map and bibliometric analysis

Vendl,

Taylor,

Bräunig

et al. 2024

Ecol Sol and Evidence

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Per‐ and polyfluoroalkyl substances (PFAS) are a large group of synthetic chemicals that have been in use for over 70 years. Their ubiquitous distribution and harmful effects pose a threat to wildlife worldwide. To provide a comprehensive synopsis and show the gaps and gluts of existing research on PFAS exposure in wildlife, we created a systematic map and bibliographic analysis of the literature. We followed our protocol to conduct a systematic literature search on Scopus, Web of Science and five other databases. In two steps (title/abstract/keywords and full‐text), we screened peer‐reviewed empirical articles, preprints and theses in English that studied the concentration of at least one of 34 PFAS compounds in free‐ranging wildlife or their parts/products. Following the protocol, we extracted data and performed a critical appraisal. We included 581 publications. From the first and only paper in 2001, there was a linear annual increase to 54 papers in 2021. While PFOS (97% of studies), PFOA (91%) and long‐chain PFAS in general were the most measured, few studies investigated new‐generation PFAS (e.g. GenX and ADONA). Across the studied 1042 species from 26 taxonomic classes, the most frequent were the common carp (Cyprinus carpio, 8%), polar bear (Ursus maritimus, 6%) and European perch (Perca fluviatilis, 5%). Most sampling took place in the United States (17%), Norway (13%), Canada (12%) and China (10%), which were also the main publishing countries. Polar regions attracted significant research interest from countries all around the globe. Aquatic habitats (marine: 31%, freshwater: 28%) of temperate zones were the most common locations for sample collection. We encourage researchers to work towards closing the following gaps: investigating new‐generation PFAS, assessing PFAS in mid‐ and low‐income countries and performing more long‐term studies, especially on invertebrates. We note the recent rise in studies on the physiological consequences of PFAS exposure and encourage further work on this crucial topic. Furthermore, we recommend that the statement of potential and actual conflicts of interest, and the provision of raw data and analysis code should be made compulsory by all journals and routinely enforced. This practice will mitigate conflict of interest and ensure reproducibility.

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Organohalogenated contaminants in white-tailed eagle (Haliaeetus albicilla) nestlings: An assessment of relationships to immunoglobulin levels, telomeres and oxidative stress

Cited by 58 publications

References 53 publications

Perfluorinated substances and telomeres in an Arctic seabird: Cross-sectional and longitudinal approaches

Perfluorinated substances and telomeres in an Arctic seabird: Cross-sectional and longitudinal approaches

Evolutionary ecology of telomeres: a review

Profiling research on PFAS in wildlife: Systematic evidence map and bibliometric analysis

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