Organogenesis and Histologic Development of the Liver

Lobritto, Steven

doi:10.1016/b978-0-7216-9654-6.50121-1

Cited by 1 publication

(1 citation statement)

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“…The endothelial cells, hematopoietic cells and connective tissue of the liver are derived from the mesoderm of the septum transversum, which later forms part of the diaphragm. The Kuppfer cells originate from the yolk sac and bone marrow (Lobritto 2004).…”

Section: Livermentioning

confidence: 99%

Hepatic Artery Hemodynamics Suggest Operation of a Buffer Response in the Human Fetus

et al. 2008

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After birth, the hepatic artery buffer response helps to maintain liver perfusion. Here, the authors establish a Doppler technique to measure fetal hepatic artery flow velocity and test the hypothesis that the buffer response also operates prenatally. Women with low-risk pregnancies were recruited to a longitudinal study (N = 161). Measurement techniques and reference ranges for hepatic artery velocities and pulsatility index (PI) were established. Ductus venosus peak velocity (V(DVps)) represented the portocaval pressure gradient, and umbilical venous flow (Q(UV)) represented portal flow. Reference ranges were established for the more accessible left hepatic artery branch. Hepatic artery PI was lower in fetuses with V(DVps) <10th centile (P < .05) and in those with Q(UV) <10th centile ( P < .0001). Conversely, hepatic artery PI was higher in those with Q(UV) >90th centile (P < .0001). The authors establish a method for measuring fetal hepatic arterial blood velocity, provide reference ranges, and show that the hepatic artery buffer response operates prenatally.

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Section: Livermentioning

confidence: 99%