Organogels: Properties and Applications in Drug Delivery

Sahoo, Smrutirekha; Kumar, Nikhil; Bhattacharya, C.; Sagiri, Sai S.; Jain, Keerti; Pal, Kunal; Ray, Sirsendu Sekhar; Nayak, Bibhuti B.

doi:10.1163/138577211x555721

Cited by 141 publications

(95 citation statements)

References 65 publications

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“…[12] LMW organogelators can result in solid or fluid fiber networks, depending on the kinetic properties of the aggregates. [10] Solidmatrix organogels are usually prepared by heating the gelator in an appropriate solvent at concentrations typically lower than 15%, and cooling the resulting solution. [8,13] The affinity between the gelator and the solvent decreases as the temperature decreases, which leads to the self-assembly of the gelator into solid aggregates held by intermolecular physical interactions.…”

Section: Introductionmentioning

confidence: 99%

“…[10] Also, conventional organogel materials have been vastly investigated for applications in pharmaceutical fields, the food industry, and the cosmetics industry. [10,11] The designability of organogels allows researchers to select gelators and solvents to achieve different purposes. The targeted functionality, design principle, and functioning mechanism of adhesive organogels are different from conventional ones.…”

mentioning

confidence: 99%

“…[7][8][9] In addition to the controlled release of small molecules, it has been reported that organogels demonstrate viscoelasticity, non-birefringence, thermoreversibility, thermostability, optical clarity, chirality effects, and biocompatibility. [10] Also, conventional organogel materials have been vastly investigated for applications in pharmaceutical fields, the food industry, and the cosmetics industry. [10,11] The designability of organogels allows researchers to select gelators and solvents to achieve different purposes.…”

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confidence: 99%

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Antiadhesion Organogel Materials: From Liquid to Solid

Yao

Zheng

et al. 2017

Advanced Materials

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According to the interaction between the gelators that composing the network, organogels can be classified as chemical organogels which are formed by covalent bonds, and physical organogels which are held by weaker physical forces such as hydrogen bonding, van der Waals' interaction, or even π-stacking interaction. [7][8][9] In addition to the controlled release of small molecules, it has been reported that organogels demonstrate viscoelasticity, non-birefringence, thermoreversibility, thermostability, optical clarity, chirality effects, and biocompatibility. [10] Also, conventional organogel materials have been vastly investigated for applications in pharmaceutical fields, the food industry, and the cosmetics industry. [10,11] The designability of organogels allows researchers to select gelators and solvents to achieve different purposes. The targeted functionality, design principle, and functioning mechanism of adhesive organogels are different from conventional ones. Usually, macroscopic phase separation into crystalline and liquid layers is prevented in conventional organogel systems owing to the balance between gelator aggregating forces and solubilizing solvent-aggregate interactions. [8] However, it should be noted that formation and long-term preservation of the surface layer, which prevents direct contact between the deposits and the substrate, is essential to design and fabricate high-performance antiadhesion organogel. It would be favorable that a sufficient amount of liquid is stored in the crosslinked network, which can act as a reservoir so that the surface layer is maintained over a long period of time. The diversity of the gelators gives us a wide range of options in designing high-performance, multifunctional, and durable antiadhesion organogels. For example, a large amount of commercial monomers, precursors, oligomers, and curing agents can be selected to prepare chemical organogels; and supramolecules as well as polyelectrolytes with specific structures can be designed to fabricate physical organogels via self-assembly.Here, we focus on the recent progress of antiadhesion organogel materials with functional surface layers on which easy removal of liquid and solid deposits can be achieved. In particular, strategies for designing multifunctional as well as durable antiadhesion organogels are discussed. Also, potential applications of antiadhesion organogels are envisioned. Preparation of Antiadhesion Organogel MaterialsAccording to the nature of the molecules, the gelators used to prepare organogels can be categorized as polymeric and Various organogel materials with either a liquid or solid surface layer have recently been designed and prepared. These surface materials can substantially reduce the adhesion of foreign deposits such as water, blood, paint, ice, and so on; therefore, they exhibit great potential for the easy removal of foreign deposits. Here, a brief discussion about the mechanism of organogel materials in reducing adhesion is given; then, examples of liquid organogels for fightin...

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Antiadhesion Organogel Materials: From Liquid to Solid

Yao

Zheng

et al. 2017

Advanced Materials

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“…Low molecular weight organogelators (LMWOGs) are gaining increased attention due to their potential applications in a variety of industrial sectors related to materials, cosmetics, health care, food and oil technology [1][2][3][4][5][6][7][8][9]. The design and elucidation of structure-property relationships of gelators is also a valuable area of research, in particular, establishing the relationship between the chemical structure of a gelator and its gelation properties in a given solvent [10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Fluorinated Organogelators for Surface Modification

Raghavanpillai

Franco

2012

Applied Sciences

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Abstract:A new class of alkyl-and perfluoroalkyl-containing urea and amide derivatives was synthesized from amino acid derivatives. Most of these compounds showed excellent gelation behavior in organic solvents at low concentrations. A few organogelators selected from the initial screening were used for surface modification of fibrous substrates to create hydrophobic and oleophobic composites. The hydrophobic and oleophobic behaviors of these composites were ascribed to a combination of increased surface roughness and the alkyl/fluorinated functionalities present in the gelator backbone.

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“…The occurrence of the gel-to-sol transition above room-temperature indicates that external energy has to be supplied to the Organogels so as to disrupt the three-dimensional structure and subsequent transformation of the gelled state to the sol state. Apart from the temperature sensitivity, Organogels are also sensitive to the presence of moisture which has also been explored to develop controlled delivery systems [7]. Various Organogel-based formulations have been designed for administration of the bioactive agents by different routes.…”

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confidence: 99%

Organogels as a Potential Topical Drug Delivery System

Jha¹,

Maurya²

2018

Int J Drug Reg Affairs

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Semisolid preparations for external application to skin have gained much demand, since it is easily absorbed through the skin layers. Many novel topical dosage forms have been discovered, among which organogels appears to play an important role. Interest in organogels has increased in a wide variety of fields including chemistry, biotechnology and pharmaceutics. Organogels are thermodynamically stable, biocompatible, isotropic gel, which not only give localized effect, but also systemic effect through percutaneous absorption. Organogels are semi-solid systems, in which an organic liquid phase is immobilized by a three-dimensional network composed of self assembled, intertwined gelator fibers. The apolar phase gets immobilized within spaces of the three-dimensional networked structure formed due to the physical interactions amongst the self assembled structures of compounds regarded as gelators. Organogels have been explored as matrices for the delivery of bioactive agents. Compared to conventional topical dosage forms, these novel formulations are found to be more advantageous and efficient. In future, organogels can give way to many promising discoveries in the field of topical dosage forms. The current review aims at giving an idea about organogels, its applications and importance in topical delivery.

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Organogels: Properties and Applications in Drug Delivery

Cited by 141 publications

References 65 publications

Antiadhesion Organogel Materials: From Liquid to Solid

Antiadhesion Organogel Materials: From Liquid to Solid

Self-Assembled Fluorinated Organogelators for Surface Modification

Organogels as a Potential Topical Drug Delivery System

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