Organochlorine Pesticide Levels in Blood Serum Samples Taken at Autopsy from Auto Accident Victims in Veracruz, Mexico

Waliszewski, Stefan M.; Carvajal, Octavio; Infanzón, R. M.; Gómez-Arroyo, Sandra; Villalobos‐Pietrini, Rafael; Trujillo, Patricia; Hart, Mary M.

doi:10.1080/00039890409603423

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…Most of the studies on OCs in Mexico have been focused on human blood or tissues − , sediment − , coastal waters − , marine biota − , and food products , . Information on the atmospheric levels of OCs in Mexico is scarce.…”

Section: Introductionmentioning

confidence: 99%

Passive Air Sampling of Organochlorine Pesticides in Mexico

Wong

Alegria

Bidleman

et al. 2008

Environ. Sci. Technol.

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The spatial and temporal variation of organochlorine pesticides (OCs) in air across Mexico was investigated by deploying passive samplers at eleven stations across the country during 2005-2006. Integrated samples were taken over three-month periods and quantified for DDT compounds, endosulfans, toxaphenes, components of technical chlordane, hexachlorocyclohexanes (HCHs), and dieldrin. Enantiomers of chiral chlordanes and o,p'-DDT were determined on chiral stationary phase columns as an indicator of source and age. Results are discussed in combination with pumped air samples taken at four other stations in southern Mexico during 2002-2004. DDT and its metabolites, endosulfan and toxaphene were the most abundant OCs detected in all sampling sites. Atmospheric concentrations of SigmaDDT (p,p'-DDT + o,p'-DDT + p,p'-DDE + o,p'-DDE + p,p'-DDD + o,p'-DDD) ranged from 15 to 2360 pg m(-3) with the highest concentrations found in southern Mexico and the lowest found in northern and central Mexico. A fresher DDT residue was observed at sites with greater DDT use and in the southern part of the country, as shown from the higher FDDTe = p,p'-DDT/(p,p'-DDT + p,p'-DDE) and nearly racemic o,p'-DDT. This agrees with the former heavy use of DDT in the endemic malarious area of the country. A local hotspot of endosulfan was identified at an agricultural area in Mazatlan, Sinaloa, with a annual mean concentration of SigmaENDO (endosulfans I + II + endosulfan sulfate) = 26,800 pg m(-3). At this site, higher concentrations of SigmaENDO were recorded during the winter (November to February) and spring (February to May) periods. From back trajectory analysis, this coincides with a shift in the air mass coming from the Pacific Ocean (May to November) to the inland agricultural area (November to May). The elevated SigmaENDO observed is likely due to the local agricultural usage. HCHs, chlordanes, transnonachlors, and dieldrin were more evenly distributed across the country likely due to them being aged residues and more diffuse in the environment. In contrast, hotspots of endosulfans, DDTs, and toxaphenes were observed as they were heavily used in localized agricultural or malarious regions of Mexico.

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Section: Introductionmentioning

confidence: 99%

Passive Air Sampling of Organochlorine Pesticides in Mexico

Wong

Alegria

Bidleman

et al. 2008

Environ. Sci. Technol.

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“…OC levels in tissues from living individuals, besides serum, breast milk, and hair, that could be obtained only by invasive procedures or during surgery (Esteban and Castano, 2009) have been reported in limited studies. It is worthwhile noting that most relevant studies performed on autopsy specimens (Williams et al, 1984;Mussalo-Rauhamma, 1991;Kemper, 1993;Galleli et al, 1995;Weistrand and Noren, 1998;Ben-Michael et al, 1999;Dewailly et al, 1999;Corrigan et al, 2000;Chu et al, 2003;Waliszewski et al, 2004), and levels of pollutants detected in the different tissues may be considered indicative of accumulation of compounds in humans.…”

Section: Residues Of Selected Polychlorinated Biphenyls (Pcb) and Orgmentioning

confidence: 96%

Residues of Selected Polychlorinated Biphenyls (PCB) and Organochlorine Pesticides (OCP) in Postmortem Lungs From Epirus, Northwestern Greece

Rallis

Boumba

Sakkas

et al. 2014

Journal of Toxicology and Environmental Health, Part A

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Organochlorine (OC) pesticides and polychlorinated biphenyls (PCB) are compounds characterized as persistent organic pollutants (POP) in the environment. These compounds are monitored globally since they enter the human body and accumulate in tissues, resulting in consequent adverse effects. In this study concentrations of selected OC compounds were determined in human autopsy lungs from Epirus, a relatively restricted region in northwestern Greece. This is the first epidemiologic study from Greece reporting on monitoring of environmental pollutants in human autopsy material. Thirty lungs collected from that number of autopsy cases were analyzed: 19 males and 11 females. The age range was 14-91 yr (mean ± SD = 61.8 ± 22.5 yr). Twenty-two cases (73%) were positive for at least one pollutant and eight cases were negative (27%). PCB were the most abundant class of contaminants, detected in 15 out of the 30 cases (50%). Dichlorodiphenyltrichloroethane (DDT) and hexachlorocyclohexanes (HCH) were second and third in abundance with 9 (30%) and 8 (27%) positive cases, respectively. The frequency of detection showed a tendency to increase with age of individuals. The patterns of OC found in human autopsy lungs were similar to those reported previously for other human specimens. Our results demonstrated a similar trend in contamination sources and distribution has occurred in western Greece as noted globally.

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“…Similar effects were observed in the experiments examining mouse Cyp3a11 mRNA levels. It is relevant to mention that adipose tissue samples from nonoccupationally exposed subjects were found to have a concentration of 1.79 mg/kg o,pЈ-DDT and 17.45 mg/kg total DDT (Waliszewski et al, 2004). Thus, modulation of CYP3A4 gene transcription by this pesticide as observed in the mouse model may be occurring in human populations and could result in drug interactions and therapeutic failures or toxicities.…”

mentioning

confidence: 99%

Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p′-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane

Medina-Díaz

Arteaga-Illán²,

León³

et al. 2006

Drug Metab Dispos

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CYP3A4 gene promoter activation resulted in both an increase in CYP3A4 mRNA levels and an increase in the total CYP3A4 activity in HepG2 cells. We also observed induction of CYP3A4 and mouse Cyp3a11 mRNA in the intestine of CYP3A4-transgenic mice after exposure to 1 mg/kg o,p-DDT. At higher doses, a decrease of CYP3A4 inducibility was observed together with an increase in levels of interleukin 6 mRNA, a proinflammatory cytokine that strongly represses CYP3A4 transcription. The present study indicates that regulation of other genes under PXR control may be altered by o,p-DDT exposure.

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Organochlorine Pesticide Levels in Blood Serum Samples Taken at Autopsy from Auto Accident Victims in Veracruz, Mexico

Cited by 7 publications

References 35 publications

Passive Air Sampling of Organochlorine Pesticides in Mexico

Passive Air Sampling of Organochlorine Pesticides in Mexico

Residues of Selected Polychlorinated Biphenyls (PCB) and Organochlorine Pesticides (OCP) in Postmortem Lungs From Epirus, Northwestern Greece

Pregnane X Receptor-Dependent Induction of the CYP3A4 Gene by o,p′-1,1,1,-Trichloro-2,2-Bis (p-Chlorophenyl)ethane

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