2009
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Abstract: The effect of organochlorine compounds (OCs) on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell (n = 520) and Gipuzkoa (n = 570), Spain. Thyroid hormones (free T4 and total T3), thyrotropin, and polychlorinated biphenyls (PCB congeners 118, 138, 153, and 180), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), dichlorodiphenyl dichloroethylene (p'p'-DDE) and dichloro… Show more

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“…We have previously demonstrated the ubiquity of exposure to OC xeno-oestrogens in the INMA-Granada cohort (54). In this study, prenatal exposure to 17 OC pesticides or the xeno-oestrogenic burden in the placentas were observed to modify the impact of neonatal TSH on neurodevelopment, in agreement with the suspected capacity of OCs to interfere with the thyroid system (20)(21)(22)(23)(24)(25)(26).…”
Section: Discussionsupporting
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…We have previously demonstrated the ubiquity of exposure to OC xeno-oestrogens in the INMA-Granada cohort (54). In this study, prenatal exposure to 17 OC pesticides or the xeno-oestrogenic burden in the placentas were observed to modify the impact of neonatal TSH on neurodevelopment, in agreement with the suspected capacity of OCs to interfere with the thyroid system (20)(21)(22)(23)(24)(25)(26).…”
Section: Discussionsupporting
“…To date, epidemiological studies have described associations of early exposure to OC compounds with TH levels (20)(21)(22)(23)(24)(25)(26) and with neurodevelopment impairment (51)(52)(53). However, a consistent influence on thyroid status and neurodevelopment of many OC compounds at environmental background levels has not been established yet.…”
Section: Discussionmentioning
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“…Organochlorine compounds are persistent environmental contaminants that were intensively used in the past as pesticides [1,2]. Some of the undesirable consequences of pesticide use include the presence of residues in the soil, water, and air; residues in plant and animal tissues and the presence of residues in food [3].…”
Section: Introductionmentioning
“…Organochlorine pesticides (OCP) are associated with many chronic diseases [4]. Many problems have been linked to these endocrine disrupters, such as neurological damage, birth defects, respiratory illness, breast cancer, lowered sperm counts and immune system dysfunction [1,5].…”
Section: Introductionmentioning