Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study

Abolhassani, Moslem; Asadikaram, Gholamreza; Paydar, Parisa; Fallah, Hossein; Aghaee-Afshar, Mahmood; Moazed, Vahid; Moghaddam, Sodaif Darvish; Moradi, A. Mashian

doi:10.1016/j.ecoenv.2019.04.030

Cited by 77 publications

(57 citation statements)

References 59 publications

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“…Due to the lipophilicity, lindane can infiltrate and accumulate in the brain, human breast milk, and other organs that are rich in fat. Epidemiological and agricultural health studies reported that lindane exposure could be associated with the cancers of the breast, prostate, lung, stomach, colon, rectum, and bladder (Jayaraj et al, 2016;Abolhassani et al, 2019;Mortazavi et al, 2019).…”

Section: Toxicity Of Lindanementioning

confidence: 99%

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

et al. 2020

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Lindane (γ-hexachlorocyclohexane) is an organochlorine pesticide that has been widely used in agriculture over the last seven decades. The increasing residues of lindane in soil and water environments are toxic to humans and other organisms. Large-scale applications and residual toxicity in the environment require urgent lindane removal. Microbes, particularly Gram-negative bacteria, can transform lindane into non-toxic and environmentally safe metabolites. Aerobic and anaerobic microorganisms follow different metabolic pathways to degrade lindane. A variety of enzymes participate in lindane degradation pathways, including dehydrochlorinase (LinA), dehalogenase (LinB), dehydrogenase (LinC), and reductive dechlorinase (LinD). However, a limited number of reviews have been published regarding the biodegradation and bioremediation of lindane. This review summarizes the current knowledge regarding lindane-degrading microbes along with biodegradation mechanisms, metabolic pathways, and the microbial remediation of lindane-contaminated environments. The prospects of novel bioremediation technologies to provide insight between laboratory cultures and largescale applications are also discussed. This review provides a theoretical foundation and practical basis to use lindane-degrading microorganisms for bioremediation.

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Section: Toxicity Of Lindanementioning

confidence: 99%

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

et al. 2020

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“…Regarding its toxicity, it has been described that pesticides act as endocrine disruptors and generators of free radicals and enzymatic inhibitors [8,9]. Unfortunately, the cellular targets to which most of these pesticides are directed coincide with cellular targets that are also present in man, such as the case of the mechanisms of action of organophosphorus insecticides, which inhibit the activity of acetylcholinesterase enzyme present in different insects; unfortunately man and other mammals also have acetylcholinesterase, so their toxicity is not selective toward the pests that they wish to control, but they also affect man, and depending on the magnitude of the poisoning, they can cause death [19][20][21][22].…”

Section: Pesticides In the Control Of Phytopathogensmentioning

confidence: 99%

“…So, they are easily incorporated into the food chain, bioaccumulation, and biomagnification [5]. Regarding their toxicity mechanisms, it has been described that they can act as endocrine disruptors and as reactive species that generate oxidative stress in the cell [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Plant Metabolites in Plant Defense Against Pathogens

Ramírez-Gómez¹,

Jiménez-García²,

Campos³

et al. 2020

Plant Diseases - Current Threats and Management Trends

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Medicinal plants are widely used worldwide to treat various diseases. Its widespread use is due in part to the cultural acceptance of traditional medicine in different regions of the world, as well as its effectiveness in treating various diseases. Many of its active substances or secondary metabolites are formed to a response of various situations that generate stress in their habitat, such as sudden changes in environmental temperature, humidity, rain, drought, and infections by phytopathogens (fungi, bacteria, viruses, nematodes, protozoa). The production of these secondary metabolites is a mechanism of defense of plants. In this context, the objective of this chapter is to study the secondary metabolites of medicinal plants that could have a promising application in the control of different phytopathogens in crops of agricultural and economic interest.

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“…Exposure to these OPPs can take place via various sources, including direct exposure, air, water, and food. Both the acute and the chronic health effects of overexposure to OPPs are well characterized, including neurological, digestive, reproductive, and respiratory disorders . Once these OPPs have entered the human body they undergo several metabolisms, typically in the liver, intestine, and lungs.…”

Section: Introductionmentioning

confidence: 99%

“…Both the acute and the chronic health effects of overexposure to OPPs are well characterized, including neurological, digestive, reproductive, and respiratory disorders. [5][6][7][8][9][10][11][12] Once these OPPs have entered the human body they undergo several metabolisms, typically in the liver, intestine, and lungs. The pervasive utilization of these chemicals and the potentially harmful effects towards human health have raised need among researchers to evaluate human exposure to them.…”

Section: Introductionmentioning

confidence: 99%

Rapid and sensitive analytical procedure for biomonitoring of organophosphate pesticide metabolites in human urine samples using a vortex‐assisted salt‐induced liquid–liquid microextraction technique coupled with ultra‐high‐performance liquid chromatography/tandem mass spectrometry

Pasupuleti

Tsai

Lin

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Organophosphate pesticides (OPPs) are the most commonly used insecticides around the world in various agricultural and domestic practices, and humans are frequently exposed to these hazardous insecticides that can lead to several chronic health effects. Therefore, a fast and sensitive analytical method is required for biomonitoring the markers of OPPs in humans for exposure estimation. In this study, a fast and sensitive analytical procedure was developed for the determination of the metabolites of OPPs in human urine samples. Methods Metabolites of OPPs were extracted from 2 mL of urine sample using a novel vortex‐assisted salt‐induced liquid–liquid microextraction (VA‐SI‐LLME) technique, and the preconcentrated metabolites were analyzed by ultra‐high‐performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS). Various factors affecting the efficiency of VA‐SI‐LLME were thoroughly investigated. Results The metabolites of OPPs exhibited very good linearity over the concentration range between 0.05 and 50 ng mL−1 with coefficient (r2) values ranging between 0.9986 and 0.9999. The method showed excellent sensitivity with detection limits ranging from 0.01 to 0.03 ng mL−1 and quantification limits from 0.03 to 0.05 ng mL−1. The developed method was applied to the analysis of real samples and the recoveries ranged between 85.0 and 114.1% with related standard deviations <5%. Conclusions The results showed the VA‐SI‐LLME/UHPLC/MS/MS method to be a simple, rapid, sensitive, and selective analytical procedure for the biomonitoring of the metabolites of OPPs in humans. This efficient and cost‐effective analytical method could be a potential alternative method for the biomonitoring of the metabolites of pesticides in humans.

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Organochlorine and organophosphorous pesticides may induce colorectal cancer; A case-control study

Cited by 77 publications

References 59 publications

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

Plant Metabolites in Plant Defense Against Pathogens

Rapid and sensitive analytical procedure for biomonitoring of organophosphate pesticide metabolites in human urine samples using a vortex‐assisted salt‐induced liquid–liquid microextraction technique coupled with ultra‐high‐performance liquid chromatography/tandem mass spectrometry

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