Organocatalyzed enantio- and diastereoselective isomerization of prochiral 1,3-cyclohexanediones into nonalactones bearing distant stereocenters

Paolis, Michaël De; d’Aleman, Antoine; Gayraud, Oscar; Fressigné, Catherine; Petit, Emilie; Maddaluno, Jacques

doi:10.1039/d2sc06842g

Cited by 1 publication

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References 60 publications

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“…Technological advances have driven various other classes of stabilizers for the biological and structural stability of CBs that offer higher internalization and fusogenicity. Examples are poly (N, N-dimethylacrylamide)-block-poly (N-isopropylacrylamide (PDMA-b-PNIPAM) [ 78 ] and poly (methyl acrylate) (PMA) and poly (poly (ethylene glycol) methyl ether acrylate) (PPEGMA) [ 79 , 80 ].…”

Section: Factors Affecting the Structure Of Cbsmentioning

confidence: 99%

Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Nath,

Dubey,

Kumar

et al. 2024

Journal of Lipids

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Topical drug delivery employing drug nanocarriers has shown prominent results in treating topical ailments, especially those confined to the skin and eyes. Conventional topical formulations persist with drug and disease‐related challenges during treatment. Various nanotechnology‐driven approaches have been adopted to mitigate the issues associated with conventional formulations. Among these, cubosomes have shown potential applications owing to their liquid crystalline structure, which aids in bioadhesion, retention, sustained release, and loading hydrophilic and hydrophobic moieties. The phase transition behavior of glyceryl monooleate, the concentration of stabilizers, and critical packing parameters are crucial parameters that affect the formation of cubosomes. Microfluidics‐based approaches constitute a recent advance in technologies for generating stable cubosomes. This review covers the recent topical applications of cubosomes for treating skin (psoriasis, skin cancer, cutaneous candidiasis, acne, and alopecia) and eye (fungal keratitis, glaucoma, conjunctivitis, and uveitis) diseases. The article summarizes the manufacturing and biological challenges (skin and ocular barriers) that must be considered and encountered for successful clinical outcomes. The patented products are successful examples of technological advancements within cosmeceuticals that support various topical applications with cubosomes in the pharmaceutical field.

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Section: Factors Affecting the Structure Of Cbsmentioning

confidence: 99%

Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Nath,

Dubey,

Kumar

et al. 2024

Journal of Lipids

View full text Add to dashboard Cite

show abstract

Organocatalyzed enantio- and diastereoselective isomerization of prochiral 1,3-cyclohexanediones into nonalactones bearing distant stereocenters

Abstract: The lactonization of 2-(2-nitrophenyl)-1,3-cyclohexanediones containing an alcohol side chain and up to three distant prochiral elements is reported by isomerization under the mediation of simple organocatalysts such as quinidine. Through...

Cited by 1 publication

References 60 publications

Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

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