Organocatalytic Enantioselective Synthesis of Inherently Chiral Calix[4]arenes
Yu‐Kun Jiang,
Yong‐Le Tian,
Jia Feng
et al.
Abstract:Inherently chiral calix[4]arenes are an excellent structural scaffold for asymmetric synthesis, chiral recognition, sensing, and circularly polarized luminescence. However, their catalytic asymmetric synthesis remains challenging. Herein, we report an efficient synthesis of inherently chiral calix[4]arene derivatives via cascade asymmetric cyclization and oxidation reactions. The three‐component reaction features a broad substrate scope (33 examples), high efficiency (up to 90% yield), and excellent enantiosel… Show more
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