Organocatalysis in Domino Processes

Organocatalytic Asymmetric Synthesis of Tetrahydrothiophenes and Tetrahydrothiopyrans

“…In recent years, organocatalytic domino reactions have played pivotal roles in the synthesis of tetrahydrothiophenes with varied substitution patterns. These one‐pot, multi‐step approaches are more attractive than traditional operations involving isolation of intermediates due to evident benefits from the points of view of economy, time and the environment.…”

N-Heterocyclic carbene/palladium synergistic catalysis in organic synthesis

“…Organocatalysts have been extensively studied in the past few decades because of their potent catalytic activity. 3 N-Heterocyclic carbenes (NHCs), in particular, are highly effective organocatalysts, due to their ability to reverse the polarity of a functional group (umpolung) and their wide applicability in asymmetric synthesis. 4 In order to enhance the utilization of NHC catalysis, multiple research teams have overcome the constraints of NHC single catalysis through an array of cooperative systems that employ an NHC catalyst with another catalyst.…”

Organocatalytic Asymmetric Dimerization of γ‐Hydroxyenones to Acetals and Theoretical Investigations into the Diastereoselection

“…The true efficiency of the formation of C–C and C–X bonds in organic chemistry relies on atom and step economy, as it allows a reduction in the amount of waste generated compared to normal processes and minimizes the amounts of chemicals required Organocatalytic domino/cascade reactions represent a powerful method to construct complex molecules with structural and functional diversity and often to create molecules having multiple stereocenters in an atom‐economic fashion.…”