Organocatalizadores en los que se simula un agujero oxianiónico

Site Selective Amide Reduction of Cyclosporine A Enables Diverse Derivation of an Important Cyclic Peptide

“…HRMS analysis of the product indicated that the residual silyl group is the bis silyl ether that would result from ring opening the O-Silyl hemiaminals such as A are additionally prone to selective chemistry. [36][37][38][39] Although we have not directly observed this intermediate by in situ 13C or 1H NMR spectroscopy, we hoped that it could be intercepted productively. To this end, CsA was reacted first with stoichiometric Et 2 SiH 2 to putatively generate A.…”

“…α-Amino nitriles can also be diversely transformed to other potentially interesting structures. 36,40 The development of amide reduction catalysts able to function under mild conditions has enabled the development of diverse site selective reactions on a complex polyamide structure. Despite being the subject of extensive synthetic studies for its diverse medicinal effects, the observed selectivities with tertiary silanes are novel.…”