Organizing the coactivity structure of the hippocampus from robust to flexible memory
Giuseppe P. Gava,
Laura Lefèvre,
Tabitha Broadbelt
et al.
Abstract:New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the hippocampus within a population activity space of highly correlated spike trains that prevents subsequent computation of a flexible (object-location) memory. This densely correlated firing structure developed over repeated mnemonic experience, gradually coupling neurons of the superficial CA1pyram… Show more
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