Organizing pneumonia secondary to lung cancer of unknown primary site

Abstract

Background Secondary organizing pneumonia (OP) is associated with other pathological conditions, such as infections, drugs, cancers and radiotherapy. Lung cancer-associated secondary OP has rarely been reported. Case review In this study, we reported on a case of secondary OP caused by lung cancer. The patient was initially diagnosed with community-acquired pneumonia and then cryptogenic organizing pneumonia by CT scan-guided and transbronchial lung biopsy. Poor response to anti-infection or corticosteroid therapy prompted us to search for underlying disease. A TBNA biopsy of the 4R mediastinal lymph node revealed the diagnosis of lung cancer. Conclusion OP secondary to lung cancer of unknown primary site are rare. When OP patients have lymphadenopathy or poor response to glucocorticoid, a more differential diagnosis should be considered, especially for avoiding the misdiagnosis of a malignancy.

Idiopathic Pulmonary Fibrosis Complicated by Adenocarcinoma and Organizing Pneumonia

“…In this case, the pathology showed conspicuous OP around the adenocarcinoma, which was thought to be one of the reasons for extensive ground-glass opacities on the chest CT. Although OP is generally well responsive to glucocorticoid therapy, there are reports of poor responsiveness in OP secondary to lung cancer [16]. In this case, glucocorticoid therapy did not improve clinical symptoms and multiple GGOs on the chest X-ray.…”

Machine-Learning-Based Classification Model to Address Diagnostic Challenges in Transbronchial Lung Biopsy

“…Such can be only seen in the surgically resected lung. Other potential contributing factors include cytokines produced by tumor cells and inflammatory elements within the tumor microenvironment, which may induce pulmonary injury and give rise to OP [28]. Given the lack of contradicting evidence and OP being associated with benign condition in our analysis, its identification in a TBLB sample should be indicative of a non-malignant condition.…”

“…OP commonly lacks a direct known causative agent, and is thus often categorized as cryptogenic OP [26]. While lung cancer-associated OP has been documented in the literature, its occurrence remains relatively uncommon [27,28]. The etiology of cancer-related OP is not definitively established, with uncertainties persisting regarding whether it represents a secondary manifestation of malignant disease, a consequence of chemo/radiation therapy, or a concomitant presentation.…”

A Case Report of Squamous Cell Carcinoma Misdiagnosed as Cryptogenic Organizing Pneumonia

“…The usual symptoms may range from nonproductive cough, mild fever to malaise, anorexia, weight loss, and progressive dyspnea [ 1 , 4 ]. Although not commonly reported, organizing pneumonia may be a manifestation of lung cancer and cause lung cancer-associated organizing pneumonia (OP) [ 6 ]. Although it is a rare manifestation, it is usually seen post-chemotherapy or radiation [ 6 ].…”

“…Although not commonly reported, organizing pneumonia may be a manifestation of lung cancer and cause lung cancer-associated organizing pneumonia (OP) [ 6 ]. Although it is a rare manifestation, it is usually seen post-chemotherapy or radiation [ 6 ].…”