“…The exact pathophysiology of DAP-induced toxicity remains unknown; however, the accumulation of DAP in tissues is thought to be one pathogenic mechanism (8,11,17). It is well known that the long-term administration of DAP results in the recruitment of T-helper 2 lymphocytes and subsequent release of interleukin-5, which induces the migration of eosinophils (27), thereby causing cellular and/or epithelial damage (8,17,28). Therefore, it usually takes at least one week for pulmonary complications to appear.…”