General concept of systemically corrupted foreign policy means long term accomplishing geo-strategic and geo-economic interests in the function of the biggest global capital in the world (Labovic, 2016). This highest and the most sophisticated type of unconventional political corruption has strong impact on the international economic and political relations, international and regional security. Systemically corrupted foreign policy is performed through the most perfidious methods, on the level of continued foreign policies. When the political, diplomatic and economic measures can not give results, as an ultima ratio-the military intervention is used in countries that are tens of thousands kilometers away from the country aggressor. Due to the above mentioned reasons, there has not been individual criminal responsibility for the killed civilians. This type of interventions eliminates the subjective criminal-law responsibility, because these activities, foreseen as criminal offences against the humanity and the international law are not treated as international criminal offences, but as a legitimate manner of conducting politics. In that context, also, special, hybrid war is used by the great powers for breaking the resistance of disobedient governments in smaller countries, which have themselves fallen into a condition where rule of law is absent, corruption is rampant and lack of respect for human rights and freedom is present. Of course, all this is done in those smaller countries with a lot less resources and not always by using extreme and/or militant means. In the context of the most immanent functions of the science, such as discovery, explanation and prognosis, in the paper have been explained thesis about the concrete interests of the great powers in the Western Balkans and especially in the Republic of Macedonia, as well as forecasts about its realization in further phases.