Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin

Groenewegen, Henk J.; Zee, E. Vermeulen-Van der; Kortschot, A. te; Witter, Menno P.

doi:10.1016/0306-4522(87)90275-2

Cited by 824 publications

(512 citation statements)

References 35 publications

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“…This enhancement in drug-induced activity following extensive hippocampal damage: (i) occurs as a direct function of increased locomotion and not indirectly, from reductions in competing behaviors [59]; (ii) is dependent on the integrity of the mesolimbic dopamine (DA) projection, as 6-OHDA lesions of the NACC block this effect [59]; (iii) occurs specifically in response to pharmacological stimulation of dopamine D2 receptors, which is consistent with the possibility of underlying receptorbased changes [38]; and (iv) corresponds to increases in amphetamine stimulated DA release in the NACC [60]. It is presumed that these changes occur as a function of the degeneration of hippocampal efferents innervating the NACC [4,17,19,20,27,50,51,55,56,63].…”

Section: Introductionmentioning

confidence: 90%

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

Kelley

Mittleman

1999

Behavioural Brain Research

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Kelley, Stephen P. and Mittleman, Guy (1999) AbstractThe main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area. Rate-intensity functions were generated from an ascending and descending series of current intensities. Lesion-induced changes in sensitivity to reward were distinguished from enhancements in motor output by calculating reward thresholds and maximal response rates from the rate-intensity functions. Rats with hippocampal damage showed lower reward thresholds and higher maximal response rates than controls. These results provide further evidence of hippocampal modulation of the nucleus accumbens, suggesting that lesions of this structure enhance sensitivity to reward and increase motor output.

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Section: Introductionmentioning

confidence: 90%

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

Kelley

Mittleman

1999

Behavioural Brain Research

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“…A major glutamatergic projection to the medial NAc shell (our injection site) originates from the ventral subiculum (Groenewegen et al, 1987(Groenewegen et al, , 1999a, a brain area critically involved in the effect of contextual cues on behavior (Bast et al, 2001;Rudy and Matus-Amat, 2005). In addition, electrical stimulation of the ventral subiculum induces reinstatement of psychostimulant seeking (Vorel et al, 2001;Taepavarapruk and Phillips, 2003).…”

Section: Neuronal Mechanisms Underlying the Effect Of Ly379268 Nac Inmentioning

confidence: 99%

“…In the studies reviewed above, however, the distinct roles of the two main subdivisions of the NAc, the core and shell (Groenewegen et al, 1987;Heimer et al, 1991), were not assessed. This anatomical distinction is important because there are reports that NAc core and shell differentially modulate the conditioned and unconditioned behavioral effects of opiate and psychostimulant drugs (Everitt and Wolf, 2002;Di Chiara et al, 2004;Ikemoto and Wise, 2004).…”

Section: Introductionmentioning

confidence: 99%

Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

Bossert

Gray

Lü

et al. 2005

Neuropsychopharmacol

215

173

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Using a rat relapse model, we previously reported that re-exposing rats to a drug-associated context, following extinction of operant responding in a different context, reinstates heroin seeking. In an initial pharmacological characterization, we found that the mGluR 2/3 agonist LY379268, which acts centrally to reduce evoked glutamate release, attenuates context-induced reinstatement of heroin seeking when injected systemically or into the ventral tegmental area, the cell body region of the mesolimbic dopamine system. Here, we tested whether injections of LY379268 into the nucleus accumbens (NAc), a terminal region of the mesolimbic dopamine system, would also attenuate context-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin; drug infusions were paired with a discrete tone-light cue. Subsequently, lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. After extinction of responding, LY379268 was injected to different groups of rats into the NAc core or shell or into the caudate-putamen, a terminal region of the nigrastriatal dopamine system. Injections of LY379268 into the NAc shell (0.3 or 1.0 mg) dose-dependently attenuated context-induced reinstatement of heroin seeking. Injections of 1.0 mg of LY379268 into the NAc core had no effect, while a higher dose (3.0 mg) decreased this reinstatement. Injections of LY379268 (3.0 mg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking.

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“…4 This point emphasizes the importance of using IVSA in the study of drug reinforcement since noncontingent drug administration does not replicate the neurochemistry of self-administered drugs. 2,5 The NAc receives glutamatergic inputs from the ventral subiculum (vSub) of the hippocampal formation 6 and this circuit has been implicated in the reinstatement of d-AMPH IVSA. Stimulation of the vSub increases NAc DA levels and reinstates d-AMPH seeking behavior in a glutamate-dependent manner.…”

Section: Introductionmentioning

confidence: 99%

Distinct proteomic profiles of amphetamine self-administration transitional states

et al. 2005

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In the rat, continuous access to d-amphetamine (d-AMPH) leads to lengthy bouts of self-administration, voluntary abstinence, and relapse to selfadministration. Previous studies have revealed that the progression from psychostimulant self-administration to abstinence to relapse is mediated in part by the ventral hippocampus. Stimulation of the ventral subiculum (vSub) during voluntary abstinence from d-AMPH self-administration reinstates self-administration and increases nucleus accumbens (NAc) dopamine efflux. Quantitative proteomic examination of the hippocampus from rats naïve to amphetamine, during a self-administration session 'Binge', during voluntarily abstinence 'Abstinent', and after reinstatement of selfadministration 'Relapse', revealed a differential proteomic state during abstinence. Actin-and cytoskeletal-related proteins were over-represented in the changes occurring during abstinence and suggest a decrease in actin filament polymerization. These changes may underlie alterations in neuronal tone during abstinence that could affect both neurotransmission and behavior. These data provide the first classification of addiction-related behaviors based on clustering of quantitative proteomic measurements.

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Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin

Cited by 824 publications

References 35 publications

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

Distinct proteomic profiles of amphetamine self-administration transitional states

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