Organization of the output of the ventral striatopallidal system in the rat: Ventral pallidal efferents

Groenewegen, H.J.; Berendse, Henk W.; Haber, Suzanne N.

doi:10.1016/0306-4522(93)90115-v

Cited by 422 publications

(333 citation statements)

References 114 publications

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“…This is not surprising as the ventral pallidum has direct anatomical connections with some of these areas [6,15 ]. Summation and lesion studies have been planned to investigate the possibility that reward from VP stimulation may be secondary to the activation of the ventral tegmental area and/or the lateral hypothaiamus.…”

Section: Discussionmentioning

confidence: 99%

“…This struc-ture, which represents the rostroventral continuation of the globus pallidus, extends beneath the anterior commissure and into the olfactory tubercle [8]. It appears to have reciprocal connections with the ventral tegmentum and the nucleus accumbens (NAC) [6,15]. In addition fibers from the ventral paUidum also reach a number of brain areas which have been suggested to play a role in reward, such as the prefrontal cortex, the lateral septum, the amygdala and the lateral hypothalamus [6].…”

Section: Introductionmentioning

confidence: 99%

“…It appears to have reciprocal connections with the ventral tegmentum and the nucleus accumbens (NAC) [6,15]. In addition fibers from the ventral paUidum also reach a number of brain areas which have been suggested to play a role in reward, such as the prefrontal cortex, the lateral septum, the amygdala and the lateral hypothalamus [6]. Furthermore, recent anatomical findings point to a compartmentalization of the ventral pallidum.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ventral pallidum self-stimulation: a moveable electrode mapping study

Panagis

Miliaressis

Anagnostakis

et al. 1995

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ventral pallidum self-stimulation: a moveable electrode mapping study

Panagis

Miliaressis

Anagnostakis

et al. 1995

Behavioural Brain Research

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“…These dendrites, which arise from DA neurons in ventral SNc, not only allow the striatum to influence DA activity, but because of dendritic DA release (Groves et al, 1975), they also allow DA to modulate the striatonigral influence in SNr (Martin and Waszczak, 1996). Interestingly, the efferent system of ventral striatum not only targets ventral pallidum but also SNc, SNr, and VTA, thus providing ventral influence on dorsal striatal circuits (Groenewegen et al, 1993). Ventral striatal projections also reach the extended amygdala, lateral hypothalamus, and pontine reticular formation.…”

Section: Information Outflowmentioning

confidence: 99%

“…NAcc core-shell distinctions have also been made at the neurophysiological (Uzwiak et al, 1997;Wood and Rebec, 2004) and neurochemical levels (Rebec et al, 1997a) in behaving rats. If, as ample evidence suggests (see Groenewegen et al, 1993), NAcc shell processes limbicrelated information having little direct access to primary motor pathways, the DA innervation of this region may be uniquely adapted to this processing role.…”

Section: Information Outflowmentioning

confidence: 99%

Behavioral Electrophysiology of Psychostimulants

Rebec

2006

Neuropsychopharmacol

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The motor-activating effects of amphetamine and other psychostimulants such as cocaine depend on an increase in dopamine (DA) transmission in the striatum, a key component of the basal ganglia and the forebrain motive circuit. This review focuses on research aimed at using electrophysiological techniquesFincluding extracellular unit recording and iontophoresisFin alert, fully functioning animals to understand how these drugs alter striatal neuronal processing under behaviorally relevant conditions. The data indicate that DA works in conjunction with glutamate (GLU), an excitatory amino acid, to enhance the signal-to-noise ratio of afferent information. This DA-GLU interaction appears to play a critical role in the amphetamine-induced activation of striatal neurons. The pattern of striatal activation, moreover, changes as the behavioral response changes from unfocused locomotion to highly focused, stereotyped behavior, but interestingly, the striatal response pattern is not reflected in substantia nigra reticulata, a primary target of striatal efferents. Although cocaine also activates striatal neurons during behavior, the underlying mechanisms appear to be complicated by factors unique to this drug and deserve further evaluation. Collectively, these findings provide unique insight into the neuronal processes by which the striatum participates in psychostimulant-induced motor behavior.

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Ventral striatopallidothalamic projection: IV. Relative involvements of neurochemically distinct subterritories in the ventral pallidum and adjacent parts of the rostroventral forebrain

Zahm¹,

Williams²,

Wohltmann³

1996

J. Comp. Neurol.

137

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Retrograde and anterograde tract-tracing studies were carried out to determine whether the capacity of the nucleus accumbens to influence the thalamic mediodorsal nucleus via ventral striatopallidothalamic connections disproportionately favors the shell over the core subterritory. After injections of Fluoro-Gold into the mediodorsal thalamic nucleus, retrogradely labeled neurons were detected in sections also processed for calbindin-D 28-kD and neurotensin immunoreactivities to facilitate identification of subterritories in the ventral pallidum. Fluoro-Gold-labeled cells were counted in series of sections cut through the ventral pallidum, rostral globus pallidus, nucleus of the vertical limb of the diagonal band, preoptic region, lateral hypothalamus, and the sublenticular gray region, including parts of the extended amygdala. Data were expressed as cells/unit area and as percentages of all labeled forebrain cells. Mediodorsal nucleus-projecting rostroventral forebrain neurons were most numerous in the ventromedial part of the subcommissural ventral pallidum and pallidal parts of the olfactory tubercle. Few were observed in the dorsolateral part of the subcommissural ventral pallidum. In addition, following injections into the ventral pallidum, anterogradely transported biotinylated dextran amine was evaluated in sections processed for calbindin or tyrosine hydroxylase immunoreactivities. Injection into the ventromedial part of the subcommissural ventral pallidum resulted in robust anterograde labeling of the medial segment of the mediodorsal nucleus and ventral tegmental area and weak labeling of the substantia nigra and subthalamic nucleus. Conversely, after injection into the dorsolateral part of the subcommissural ventral pallidum, anterograde labeling was weak in the mediodorsal nucleus and ventral tegmental area, but robust in the substantia nigra and subthalamic nucleus. The results are consistent with a predominant accumbens shell influence on the mediodorsal nucleus and with cortico-ventral striatopallidal-thalamocortical pathways that begin and end in different parts of the frontal lobe.

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Organization of the output of the ventral striatopallidal system in the rat: Ventral pallidal efferents

Cited by 422 publications

References 114 publications

Ventral pallidum self-stimulation: a moveable electrode mapping study

Ventral pallidum self-stimulation: a moveable electrode mapping study

Behavioral Electrophysiology of Psychostimulants

Ventral striatopallidothalamic projection: IV. Relative involvements of neurochemically distinct subterritories in the ventral pallidum and adjacent parts of the rostroventral forebrain

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