Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

Niu, Meiqi; Rapan, Lucija; Funck, Thomas; Zhao, Ling; Zilles, Karl; Palomero-Gallagher, Nicola

doi:10.1016/j.neuroimage.2021.117843

Cited by 22 publications

(35 citation statements)

References 79 publications

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“…Collection of this data is underway and will be made available in future studies. With the exception of the receptor densities in the posterior parietal cortex (Impieri et al, 2019;Niu et al, 2020Niu et al, , 2021, all D1 receptor densities are reported for the first time in this study. The connectivity data for ten of the 40 cortical areas is used here for the first time, but will be described in more detail in an upcoming publication from the Kennedy lab.…”

Section: Overview Of Anatomical Datamentioning

confidence: 56%

A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

Bliss

Ding

Rapan

et al. 2021

Neuron

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Dopamine is required for working memory, but how it modulates the large-scale cortex is unknown. Here, we report that dopamine receptor density per neuron, measured by autoradiography, displays a macroscopic gradient along the macaque cortical hierarchy. This gradient is incorporated in a connectome-based large-scale cortex model endowed with multiple neuron types. The model captures an inverted U-shaped dependence of working memory on dopamine and spatial patterns of persistent activity observed in over 90 experimental studies. Moreover, we show that dopamine is crucial for filtering out irrelevant stimuli by enhancing inhibition from dendrite-targeting interneurons. Our model revealed that an activity-silent memory trace can be realized by facilitation of inter-areal connections and that adjusting cortical dopamine induces a switch from this internal memory state to distributed persistent activity. Our work represents a cross-level understanding from molecules and cell types to recurrent circuit dynamics underlying a core cognitive function distributed across the primate cortex.

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Section: Overview Of Anatomical Datamentioning

confidence: 56%

A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

Bliss

Ding

Rapan

et al. 2021

Neuron

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“…Quantitative in-vitro receptor autoradiography was applied to determine the densities of NMDA and receptors in cytoarchitectonically identified cortical areas of the macaque monkey brain (Impieri et al 2019;Niu et al 2020Niu et al , 2021Rapan et al 2021). We provide a short description of the method to help the reader understand how receptor data serves to enrich the connectome-based dynamical model.…”

Section: In-vitro Receptor Autoradiographymentioning

confidence: 99%

“…Therefore, in addition to feedforward AMPA and feedback NMDA connections, our model suggests that NMDA receptors at local excitatory connections are crucial for ignition of cortical activity in response to a stimulus, in support of the previous theoretical(Wang 1999) and experimental(Wang et al 2013) findings.DiscussionWe developed a novel large-scale model of monkey cortex and used it to simulate a detection task. The present work builds upon a previously proposed global neuronal workspace (GNW) architecture(Dehaene et al 2003;Dehaene and Changeux 2005), but now incorporating newly available weighted and directed cortical connectivity data(Froudist- Walsh et al 2021a;Markov et al 2014Markov et al , 2012Markov et al 2013;Mejias et al 2016) and receptor data(Froudist- Walsh et al 2021b;Impieri et al 2019;Niu et al 2020Niu et al , 2021Rapan et al 2021). Using this model, we replicated multiple spatial and temporal features of neural activity that are observed during conscious perception.…”

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confidence: 99%

A connectome-based model of conscious access in monkey cortex

Klatzmann

Bliss

Theodoni

et al. 2022

Preprint

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A growing body of evidence suggests that conscious perception of a sensory stimulus triggers an all-or-none activity across multiple cortical areas, a phenomenon called 'ignition'. In contrast, the same stimulus, when undetected, induces only transient activity. In this work, we report a large-scale model of the macaque cortex based on recently quantified structural connectome data. We use this model to simulate a detection task, and demonstrate how a dynamical bifurcation mechanism produces ignition-like events in the model network. Within this framework, the model predicts that feedforward excitatory transmission is primarily mediated by the fast AMPA receptors to ensure rapid signal propagation from sensory to associative areas. In contrast, a large fraction of the inter-areal feedback projections and local recurrent excitation depend on the slow NMDA receptors, to ensure ignition of distributed frontoparietal activity. Our model predicts, counterintuitively, that fast-responding sensory areas contain a higher ratio of NMDA to AMPA receptors compared to association cortical areas that show slow, sustained activity. We validate this prediction using in-vitro receptor autoradiography data. Finally, we show how this model can account for various behavioral and physiological effects linked to consciousness. Together, these findings clarify the neurophysiological mechanisms of conscious access in the primate cortex and support the concept that gradients of receptor densities along the cortical hierarchy contribute to distributed cognitive functions.

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“…One-hundred-and-nine cortical areas were defined based on their receptor-and cyto-architecture, as described in (Impieri et al, 2019;Niu et al, 2021Niu et al, , 2020Rapan et al, 2020) and upcoming publications on the prefrontal cortex, cingulate and occipital lobe. We call this parcellation the Julich Macaque Brain Atlas.…”

Section: Creation Of Surface Representation Of Cyto-and Receptor-architectonic Atlas and Receptor Datamentioning

confidence: 99%

Gradients of receptor expression in the macaque cortex

Niu

Rapan

et al. 2021

Preprint

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Dynamics and functions of neural circuits depend on synaptic interactions mediated by receptors. Therefore, a comprehensive map of receptor organization is needed to understand how different functions may emerge across distinct cortical regions. Here we use in-vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrate the receptor data with other anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of increasing receptor expression per neuron aligned with cortical hierarchy from early sensory cortex to higher cognitive areas. A second gradient, primarily driven by 5-HT1A receptors, peaks in the anterior and subcallosal cingulate, suggesting that the macaque may be a promising animal model for major depressive disorder. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration of information in higher cognitive areas.

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Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

Cited by 22 publications

References 79 publications

A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

A connectome-based model of conscious access in monkey cortex

Gradients of receptor expression in the macaque cortex

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