Organization of the Addax Major Histocompatibility Complex Provides Insights Into Ruminant Evolution

Li, Chaokun; Huang, Rui; Nie, Fangyuan; Li, Jiujie; Zhu, Wen; Shi, Xiaoqian; Guo, Yu; Chen, Yan; Wang, Shiyu; Zhang, Limeng; Chen, Longxin; Zhao, Yuanli; Liu, Xuefeng; Zheng, Changming; Zhang, Chenglin; Runlin, Z.

doi:10.3389/fimmu.2020.00260

Cited by 5 publications

(3 citation statements)

References 70 publications

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“…Cattle (Bos Taurus), addax (Addax nasomaculatus), as well as other mammals, all have their MHCI and MHCII genes encoded within one chromosomal region (Kulski et al, 2002;Traherne, 2008;Shiina et al, 2009;Behl et al, 2012;Li et al, 2020). Most species have unique numbers of MHCI and MHCII genes as exemplified by cattle with three DRB genes, two DQB genes and haplotypes ranging from 3 to 4 polymorphic MHCI genes (Behl et al, 2012;Schwartz et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Most species have unique numbers of MHCI and MHCII genes as exemplified by cattle with three DRB genes, two DQB genes and haplotypes ranging from 3 to 4 polymorphic MHCI genes (Behl et al, 2012;Schwartz et al, 2022). Comparatively, the addax has seven MHCI genes with unknown polymorphism and expression patterns, three expressed DRB genes and one expressed DQB gene (Li et al, 2020). Humans on the other hand, have nine DRB genes present in various combinations in different haplotypes (Andersson et al, 1987;Doxiadis et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Functional immune diversity in reindeer reveals a high Arctic population at risk

Lukacs

Nymo²,

Madslien³

et al. 2023

Front. Ecol. Evol.

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Climate changes the geographic range of both species as well as pathogens, causing a potential increase in the vulnerability of populations or species with limited genetic diversity. With advances in high throughput sequencing (HTS) technologies, we can now define functional expressed genetic diversity of wild species at a larger scale and identify populations at risk. Previous studies have used genomic DNA to define major histocompatibility complex (MHC) class II diversity in reindeer. Varying numbers of expressed genes found in many ungulates strongly argues for using cDNA in MHC typing strategies to ensure that diversity estimates relate to functional genes. We have used available reindeer genomes to identify candidate genes and established an HTS approach to define expressed MHC class I and class II diversity. To capture a broad diversity we included samples from wild reindeer from Southern Norway, semi-domesticated reindeer from Northern Norway and reindeer from the high Artic archipelago Svalbard. Our data show a medium MHC diversity in semi-domesticated and wild Norwegian mainland reindeer, and low MHC diversity reindeer in Svalbard reindeer. The low immune diversity in Svalbard reindeer provides a potential risk if the pathogenic pressure changes in response to altered environmental conditions due to climate change, or increased human-related activity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional immune diversity in reindeer reveals a high Arctic population at risk

Lukacs

Nymo²,

Madslien³

et al. 2023

Front. Ecol. Evol.

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show abstract

“…Previous studies have revealed that most economic traits are regulated by candidate mRNAs and complex biological networks of non-coding RNAs in livestock ( Zhang et al, 2018 ; Muret et al, 2019 ; Zhao et al, 2021 ). In 2020, Li et al (2020) found that most (77.65%) of the rumen core genes were enriched with ruminant-specific non-coding conservative sequences. Among them, long non-coding RNAs (lncRNAs) specifically participate in many critical regulatory processes at the epigenetic, transcription, post-transcriptional, translation, and post-translational levels and also play vital roles in various cellular processes ( Wei et al, 2017 ; Wang et al, 2018 ; Vafadar et al, 2019 ; Zhang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNA-mRNA modules involved in goat rumen development: Insights from genome-wide transcriptome profiling

Zhong

Zhao²,

Zhan³

et al. 2022

Front. Physiol.

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The rumen is an essential digestive and absorption organ of ruminants. During fetal life, lactation, and post-weaning period, goat rumen undergoes drastic morphological and metabolic-functional changes triggered by potential regulated genes and non-coding RNA molecules. As the essential regulatory factors, long non-coding RNAs (lncRNAs) have vital functions in various biological activities. However, their roles during rumen development are still poorly explored in ruminants. To explore the genome-wide expression profiles of lncRNAs and mRNAs in the goat rumens, we generated 5,007 lncRNAs and 19,738 mRNAs identified during the fetal and prepubertal stages by the high-throughput RNA sequencing. Notably, 365 lncRNAs and 2,877 mRNAs were considered to be differentially expressed. The weighted gene co-expression network analysis and functional analysis were performed to explore the regulatory roles of those differentially expressed molecules. The cis-and trans-target genes of differently expressed lncRNAs were enriched for pathways related to focal adhesion, cGMP-PKG signaling pathway, alpha-linolenic acid metabolism, arachidonic acid metabolism, and fat digestion and absorption. Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes analyses showed that the differently expressed genes mainly participated in mitotic cytokinesis, desmosome, fatty acid degradation, cell adhesion molecules, and fatty acid metabolism. The prediction of lncRNA-mRNA interaction networks further revealed transcripts potentially involved in rumen development. The present study profiles a global overview of lncRNAs and mRNAs during rumen development. Our findings provide valuable resources for genetic regulation and molecular mechanisms of rumen development in ruminants.

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Copy number and selection of MHC genes in ruminants are related to habitat, average life span and diet

He,

Liang,

et al. 2024

Gene

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Organization of the Addax Major Histocompatibility Complex Provides Insights Into Ruminant Evolution

Cited by 5 publications

References 70 publications

Functional immune diversity in reindeer reveals a high Arctic population at risk

Functional immune diversity in reindeer reveals a high Arctic population at risk

LncRNA-mRNA modules involved in goat rumen development: Insights from genome-wide transcriptome profiling

Copy number and selection of MHC genes in ruminants are related to habitat, average life span and diet

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