Organization of serotonergic system in Sphaerotheca breviceps (Dicroglossidae) tadpole brain

Bhat, Shilpa K.; Ganesh, C.B.

doi:10.1007/s00441-022-03709-7

Cited by 5 publications

(6 citation statements)

References 89 publications

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“…The border effect has been reported in different species, but it usually has been interpreted in a brain region-centric way, without generalizing the pattern. Interesting examples are provided by the telencephalon of the New Zealand white rabbit ( Bjarkam et al, 2003 , 2005 ) and the tadpole telencephalon of the Indian burrowing frog ( Bhat and Ganesh, 2023 ). A study of serotonergic densities in the hamster brain has noted that, “in the thalamus, there is a general theme of denser 5-HT-IR [serotonergic] innervation surrounding a sparsely innervated core” ( Morin and Meyer-Bernstein, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

“…The self-organization of the brain serotonergic matrix remains an unsolved problem in neuroscience. This matrix, or a meshwork of axons (fibers), is present in virtually all brain regions, likely across the entire vertebrate clade ( Wolters et al, 1985 ; Challet et al, 1991 , 1996 ; Stuesse et al, 1991 ; Metzger et al, 2002 ; López and González, 2014 ; Janušonis, 2018 ; Awasthi et al, 2021 ; Bhat and Ganesh, 2023 ). It appears to be fundamentally associated with neuroplasticity ( Lesch and Waider, 2012 ; Teissier et al, 2017 ; Daws et al, 2022 ), raising new questions ( Vargas et al, 2023 ), and is remarkable in its ability to robustly regenerate in the adult mammalian brain ( Jin et al, 2016 ; Cooke et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model

Janušonis

Haiman

Metzler

et al. 2023

Front. Comput. Neurosci.

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The self-organization of the brain matrix of serotonergic axons (fibers) remains an unsolved problem in neuroscience. The regional densities of this matrix have major implications for neuroplasticity, tissue regeneration, and the understanding of mental disorders, but the trajectories of its fibers are strongly stochastic and require novel conceptual and analytical approaches. In a major extension to our previous studies, we used a supercomputing simulation to model around one thousand serotonergic fibers as paths of superdiffusive fractional Brownian motion (FBM), a continuous-time stochastic process. The fibers produced long walks in a complex, three-dimensional shape based on the mouse brain and reflected at the outer (pial) and inner (ventricular) boundaries. The resultant regional densities were compared to the actual fiber densities in the corresponding neuroanatomically-defined regions. The relative densities showed strong qualitative similarities in the forebrain and midbrain, demonstrating the predictive potential of stochastic modeling in this system. The current simulation does not respect tissue heterogeneities but can be further improved with novel models of multifractional FBM. The study demonstrates that serotonergic fiber densities can be strongly influenced by the geometry of the brain, with implications for brain development, plasticity, and evolution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model

Janušonis

Haiman

Metzler

et al. 2023

Front. Comput. Neurosci.

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“…In addition, the distribution and function of serotonergic neurons in fish have already been reviewed ( Lillesaar, 2011 ). In amphibians, the organization of central serotonergic neurons has been described in several species, including salamander ( Dubé and Parent, 1982 ; Clairambault et al, 1994 ; Dicke et al, 1997 ) and frog ( van Mier et al, 1986 ; Bhat and Ganesh, 2023 ). In reptiles, the location of serotonergic neurons has been described in several species, such as turtle ( Ueda et al, 1983 ), lizard ( Smeets and Steinbusch, 1988 ), snake ( Challet et al, 1991 ), and crocodile ( Rodrigues et al, 2008 ).…”

Section: Molecular Dissections Of the Serotonergic System In The Chic...mentioning

confidence: 99%

Molecular biology of serotonergic systems in avian brains

Fujita

Aoki

Mori

et al. 2023

Front. Mol. Neurosci.

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Serotonin (5-hydroxytryptamine, 5-HT) is a phylogenetically conserved neurotransmitter and modulator. Neurons utilizing serotonin have been identified in the central nervous systems of all vertebrates. In the central serotonergic system of vertebrate species examined so far, serotonergic neurons have been confirmed to exist in clusters in the brainstem. Although many serotonin-regulated cognitive, behavioral, and emotional functions have been elucidated in mammals, equivalents remain poorly understood in non-mammalian vertebrates. The purpose of this review is to summarize current knowledge of the anatomical organization and molecular features of the avian central serotonergic system. In addition, selected key functions of serotonin are briefly reviewed. Gene association studies between serotonergic system related genes and behaviors in birds have elucidated that the serotonergic system is involved in the regulation of behavior in birds similar to that observed in mammals. The widespread distribution of serotonergic modulation in the central nervous system and the evolutionary conservation of the serotonergic system provide a strong foundation for understanding and comparing the evolutionary continuity of neural circuits controlling corresponding brain functions within vertebrates. The main focus of this review is the chicken brain, with this type of poultry used as a model bird. The chicken is widely used not only as a model for answering questions in developmental biology and as a model for agriculturally useful breeding, but also in research relating to cognitive, behavioral, and emotional processes. In addition to a wealth of prior research on the projection relationships of avian brain regions, detailed subdivision similarities between avian and mammalian brains have recently been identified. Therefore, identifying the neural circuits modulated by the serotonergic system in avian brains may provide an interesting opportunity for detailed comparative studies of the function of serotonergic systems in mammals.

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“…These axons participate in neurosignaling by releasing 5hydroxytryptamine (5-HT, serotonin) and can also release other neurotransmitters. 1 The cellular origin and distribution of serotonergic fibers have been described in all vertebrate groups: the cartilaginous and bony fishes, [2][3][4] the amphibians, 5 the reptiles, 6 the birds, 7,8 and the mammals. 9,10 The ubiquitous presence and high energetic cost of this fiber matrix suggests that it provides fundamental support for neural networks of the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Qualitative Observations of Transgenically Individualized Serotonergic Fibers in the Mouse Telencephalon

Haiman,

Mays,

Roostaeyan

et al. 2023

Preprint

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The matrix of serotonergic axons (fibers) is a constant feature of neural tissue in vertebrate brains. Its fundamental role appears to be associated with the spatiotemporal control of neuroplasticity. The densities of serotonergic fibers vary across brain regions, but their development and maintenance remain poorly understood. A specific fiber concentration is achieved as the result of the dynamics of a large number of individual fibers, each of which can make trajectory decisions independently of other fibers. Bridging these processes, operating on very different spatial scales, remains a challenge in neuroscience. The study provides the first qualitative description of individually-tagged serotonergic axons in four selected telencephalic regions (cortical and subcortical) of the mouse brain. Based on our previous implementation of the Brainbow toolbox in this system, serotonergic fibers were labeled with random intensity combinations of three fluorophores and imaged with high-resolution confocal microscopy. All examined regions contained serotonergic fibers of diverse identities and morphologies, often traveling in close proximity to one another. Some fibers transitioned among several morphologies in the same imaged volume. High fiber densities appeared to be associated with highly tortuous fiber segments produced by some individual fibers. This study supports efforts to predictively model the self-organization of the serotonergic matrix in all vertebrates, including regenerative processes in the adult human brain.

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Organization of serotonergic system in Sphaerotheca breviceps (Dicroglossidae) tadpole brain

Cited by 5 publications

References 89 publications

Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model

Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model

Molecular biology of serotonergic systems in avian brains

Qualitative Observations of Transgenically Individualized Serotonergic Fibers in the Mouse Telencephalon

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