Organization of retrosplenial cortical projections to the anterior cingulate, motor, and prefrontal cortices in the rat

Shibata, Hideshi; Kondo, Shin‐ichiro; Naito, Jumpei

doi:10.1016/j.neures.2004.01.005

Cited by 64 publications

(60 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We used the same injection method as described in BDA injections. Goat anti-CTb IgG (1:20,000, 12 h at 4°C; List Biological Laboratories) was used for primary antibody, and biotinylated donkey anti-goat IgG (Jackson ImmunoResearch) was used for secondary antibody before the reaction with the avidin-biotin complex (ABC Elite; Vector Laboratories) (Luppi et al, 1990;Shibata et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Demonstration of a Neural Circuit Critical for Imprinting Behavior in Chicks

Nakamori

Sato²,

Atoji³

et al. 2010

J. Neurosci.

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Demonstration of a Neural Circuit Critical for Imprinting Behavior in Chicks

Nakamori

Sato²,

Atoji³

et al. 2010

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…In addition, these regions issue the most appropriate motor commands to the brainstem and spinal cord so that adaptive spatial behaviors can be performed (see, e.g., Wise and Donoghue, 1986;Vogt et al, 1997;Gabbott et al, 2005). We recently demonstrated that the retrosplenial cortex projects to the anterior cingulate, motor, and orbital cortices more extensively than previously assumed (Shibata et al, 2004). We also showed that each subdivision of the retrosplenial cortex-areas 29a, 29b, 29c, and 29d-provides a distinct set of frontal cortical projections, most of which are topographically organized (Shibata et al, 2004).…”

mentioning

confidence: 97%

“…Indeed, cells in the retrosplenial cortex have been shown to encode head direction (Chen et al, 1994a,b) or combinations of direction, location, and movement of an animal (Cho and Sharp, 2001). Furthermore, retrosplenial cells have also been implicated in path integration associated with spatial navigation (Cooper and Mizumori, 1999;Cooper et al, 2001).The neural circuitry interconnecting the retrosplenial cortex and other cortical regions forms part of the anatom- 1990Shibata, 1994;Shibata et al, 2004). Among these cortical regions, the anterior cingulate and frontal motor and association cortices are important for spatial functions of the retrosplenial cortex, in that these cingulate and frontal regions may be involved in responseselection and decision-making processes.…”

mentioning

confidence: 99%

Organization of anterior cingulate and frontal cortical projections to the retrosplenial cortex in the rat

Shibata

Naito

2007

J of Comparative Neurology

Self Cite

View full text Add to dashboard Cite

The retrosplenial cortex (areas 29a-d), which plays an important role in spatial memory and navigation, is known to provide massive projections to frontal association and motor cortices, which are also essential for spatial behavior. The reciprocal projections originating from these frontal cortices to areas 29a-d, however, have been analyzed to only a limited extent. Here, we report an analysis of the anatomical organization of projections from anterior cingulate area 24 and motor and prefrontal cortices to areas 29a-d in the rat, using the axonal transport of cholera toxin B subunit and biotinylated dextran amine. Area 29a receives projections from rostral area 24a, area 24b, the ventral orbital area, and the caudal secondary motor area. Rostral area 29b receives projections from caudal area 24a, whereas caudal area 29b receives projections from rostral area 24a. Area 29b also receives projections from area 24b and the ventral orbital area. Areas 29c and 29d receive projections from areas 24a and 24b and the secondary motor area in a topographic manner such that the rostrocaudal axis of areas 29c and 29d corresponds to the caudorostral axis of areas 24a and 24b and the secondary motor area. Rostral areas 29c and 29d also receive projections from the caudal primary motor area, and area 29d receives projections from the ventral, lateral, and medial orbital areas. These differential frontal cortical projections to each area of the retrosplenial cortex suggest that each area may contribute to different aspects of retrosplenial cortical function such as spatial memory and behavior.

show abstract

“…Such a decrease in c-Fos-positive neurons may also reflect the deactivation or inhibition of some functions of area 30 at a specific time point of spatial memory formation. Area 30 is reciprocally connected with visual, motor, association prefrontal, and posterior parietal cortices (Shibata and Naito 2008, Shibata et al 2004, van Groen and Wyss 1992, suggesting that it is involved in the sensorimotor integration and execution of spatial behavior (Vogt and Miller 1983). On the third day of place avoidance training in the present study, the role of area 30 in performing such a demanding avoidance task may rely on inhibition of the strategies that do not serve to optimize it.…”

Section: Area 30mentioning

confidence: 55%

Spatial memory formation differentially affects c-Fos expression in retrosplenial areas during place avoidance training in rats

Malinowska¹,

Niewiadomska²,

Wesierska³

2016

Acta Neurobiologiae Experimentalis

View full text Add to dashboard Cite

Authors' contributions: M.M. designed the research; M.M. and M.W. performed the research, analyzed the data and wrote the paper; M.N. performed ~20% of the research.The retrosplenial cortex is involved in spatial memory function, but the contribution of its individual areas is not well known. To elucidate the involvement of retrosplenial cortical areas 29c and 30 in spatial memory, we analyzed the expression of c-Fos in these areas in the experimental group of rats that were trained in a spatial place avoidance task, i.e. to avoid shocks presented in an unmarked sector of a stable arena under light conditions. Control rats were trained in the same context as the experimental rats either without (Control-noUS) or with shocks (Control-US) that were delivered in a random, noncontingent manner for three days. On the first day of place avoidance learning, the experimental group exhibited c-Fos induction in area 29c, similar to both control groups. In area 30, similarly high levels of c-Fos expression were observed in the experimental and Control-US groups. On the third day of training, when the experimental group efficiently avoided c-Fos expression in areas 29c and 30 was lower compared with the first day of training. In area 29c c-Fos level was also lower in the experimental group in comparison to the Control-US group. In area 30, c-Fos expression in the experimental group was lower than in both control groups. In conclusion, areas 29c and 30 appear to be activated during spatial memory acquisition on the first day of training, whereas area 30 seems suppressed during long-term memory functioning on the third day of training when rats effectively avoid.

show abstract

Organization of retrosplenial cortical projections to the anterior cingulate, motor, and prefrontal cortices in the rat

Cited by 64 publications

References 43 publications

Demonstration of a Neural Circuit Critical for Imprinting Behavior in Chicks

Demonstration of a Neural Circuit Critical for Imprinting Behavior in Chicks

Organization of anterior cingulate and frontal cortical projections to the retrosplenial cortex in the rat

Spatial memory formation differentially affects c-Fos expression in retrosplenial areas during place avoidance training in rats

Contact Info

Product

Resources

About