Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells

Jun, Soyoung; Kim, Muwoong; Park, Heeyoun; Hwang, Eunmi; Yamamoto, Yukio; Tanaka-Yamamoto, Keiko

doi:10.1016/j.celrep.2023.113137

Cited by 1 publication

(1 citation statement)

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“…To address the important question of how region-specific astrocytes exhibit differential transcription, additional studies are essential to identify the underlying mechanisms specific to these astrocytes. While we acknowledge the need for further investigation, we posit that this difference may be regulated by transcription factors within region-specific astrocytes or through interactions with neurons specific to those regions during development [38,39].…”

Section: Distinct and Conserved Gene Signatures In The Transcriptome ...mentioning

confidence: 99%

Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions

Kwon,

Choi,

et al. 2024

IJMS

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Astrocytes are the most abundant glial cell type in the central nervous system, and they play a crucial role in normal brain function. While gliogenesis and glial differentiation occur during perinatal cerebellar development, the processes that occur during early postnatal development remain obscure. In this study, we conducted transcriptomic profiling of postnatal cerebellar astrocytes at postnatal days 1, 7, 14, and 28 (P1, P7, P14, and P28), identifying temporal-specific gene signatures at each specific time point. Comparing these profiles with region-specific astrocyte differentially expressed genes (DEGs) published for the cortex, hippocampus, and olfactory bulb revealed cerebellar-specific gene signature across these developmental timepoints. Moreover, we conducted a comparative analysis of cerebellar astrocyte gene signatures with gene lists from pediatric brain tumors of cerebellar origin, including ependymoma and medulloblastoma. Notably, genes downregulated at P14, such as Kif11 and HMGB2, exhibited significant enrichment across all pediatric brain tumor groups, suggesting the importance of astrocytic gene repression during cerebellar development to these tumor subtypes. Collectively, our studies describe gene expression patterns during cerebellar astrocyte development, with potential implications for pediatric tumors originating in the cerebellum.

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Section: Distinct and Conserved Gene Signatures In The Transcriptome ...mentioning

confidence: 99%

Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions

Kwon,

Choi,

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells

Cited by 1 publication

References 93 publications

Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions

Comparative Transcriptomic Analysis of Cerebellar Astrocytes across Developmental Stages and Brain Regions

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