Organization of Multisynaptic Inputs to the Dorsal and Ventral Dentate Gyrus: Retrograde Trans-Synaptic Tracing with Rabies Virus Vector in the Rat

Ohara, Shinya; Sato, Sho; Tsutsui, Ken; Witter, Menno P.; Iijima, Toshio

doi:10.1371/journal.pone.0078928

Cited by 40 publications

(40 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using retrograde transsynaptic viral tracers to identify first- and second-order inputs to the dorsal or ventral DG, Ohara et al (2013) recently showed that the SUM (as well as the MS and EC) was a first-order input to DG and confirmed earlier findings (Soussi et al, 2010; Vertes, 1992) that the medial SUM primarily distributes to the ventral DG and the lateral SUM to the dorsal DG. In line with the notion that the dorsal HF is primarily involved in spatial behaviors and the ventral HF in affective states (Fanselow and Dong, 2010), Ohara et al (2013) demonstrated that second-order fibers to the ventral DG (largely routed through the medial SUM) primarily originated from “affective” structures such as the ventromedial and dorsal hypothalamus, the preoptic area, and the infralimbic cortex (IL) cortex.…”

Section: Sum: Anatomysupporting

confidence: 65%

“…Several reports have shown that the SUM is a major source of afferents to the hippocampus (Amaral and Cowan, 1980; Haglund et al, 1984; Harley et al, 1983; Leranth and Hajszan, 2007; Magloczky et al, 1994; Ohara et al, 2013; Soussi et al, 2010; Vertes, 1992; Vertes and McKenna, 2000; Wyss et al, 1979). For instance, Amaral and Cowan (1980) initially demonstrated that hippocampal injections of horseradish peroxidase in the monkey produced dense retrograde cell labeling in SUM—or equivalent or even greater than that seen in the septum with these injections.…”

Section: Sum: Anatomymentioning

confidence: 99%

See 1 more Smart Citation

Major diencephalic inputs to the hippocampus

Vertes

2015

Progress in Brain Research

View full text Add to dashboard Cite

The hippocampus receives two major external inputs from the diencephalon, that is, from the supramammillary nucleus (SUM) and nucleus reuniens (RE) of the midline thalamus. These two afferents systems project to separate, nonoverlapping, regions of the hippocampus. Specifically, the SUM distributes to the dentate gyrus (DG) and to CA2 of the dorsal and ventral hippocampus, whereas RE projects to CA1 of the dorsal and ventral hippocampus and to the subiculum. SUM and RE fibers to the hippocampus participate in common as well as in separate functions. Both systems would appear to amplify signals from other sources to their respective hippocampal targets. SUM amplifies signals from the entorhinal cortex (EC) to DG, whereas RE may amplify them from CA3 (and EC) to CA1 of the hippocampus. This “amplification” may serve to promote the transfer, encoding, and possibly storage of information from EC to DG and from CA3 and EC to CA1. Regarding their unique actions on the hippocampus, the SUM is a vital part of an ascending brainstem to hippocampal system generating the theta rhythm of the hippocampus, whereas RE importantly routes information from the medial prefrontal cortex to the hippocampus to thereby mediate functions involving both structures. In summary, although, to date, SUM and RE afferents to the hippocampus have not been extensively explored, the SUM and RE exert a profound influence on the hippocampus in processes of learning and memory.

show abstract

Section: Sum: Anatomysupporting

confidence: 65%

Section: Sum: Anatomymentioning

confidence: 99%

Major diencephalic inputs to the hippocampus

Vertes

2015

Progress in Brain Research

View full text Add to dashboard Cite

show abstract

“…Our manipulation affects both the ipsilateral and contralateral CA3-CA1 projections originating in one hemisphere; although both ipsilateral and contralateral projections do show equivalent LTP in rats (36) and mice (11), we currently cannot exclude the possibility that they play independent roles. It is also conceivable that the asymmetry in long-term memory is explained either completely or in part because the left and right CA3 receive different information, akin to how the distinct functional contributions of dorsal and ventral hippocampus might arise through differences in first-and second-order inputs (37). One possible source of asymmetry before the hippocampus might be the lateral entorhinal cortex (LEC) input to dorsal hippocampus; the left LEC exhibits a higher metabolic demand than the right LEC (38), which may be indicative of distinct computational demands present in the neuronal circuitry.…”

Section: Discussionmentioning

confidence: 99%

Left–right dissociation of hippocampal memory processes in mice

Shipton

El-Gaby

Apergis-Schoute

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

163

222

View full text Add to dashboard Cite

Left-right asymmetries have likely evolved to make optimal use of bilaterian nervous systems; however, little is known about the synaptic and circuit mechanisms that support divergence of function between equivalent structures in each hemisphere. Here we examined whether lateralized hippocampal memory processing is present in mice, where hemispheric asymmetry at the CA3-CA1 pyramidal neuron synapse has recently been demonstrated, with different spine morphology, glutamate receptor content, and synaptic plasticity, depending on whether afferents originate in the left or right CA3. To address this question, we used optogenetics to acutely silence CA3 pyramidal neurons in either the left or right dorsal hippocampus while mice performed hippocampus-dependent memory tasks. We found that unilateral silencing of either the left or right CA3 was sufficient to impair short-term memory. However, a striking asymmetry emerged in long-term memory, wherein only left CA3 silencing impaired performance on an associative spatial long-term memory task, whereas right CA3 silencing had no effect. To explore whether synaptic properties intrinsic to the hippocampus might contribute to this left-right behavioral asymmetry, we investigated the expression of hippocampal long-term potentiation. Following the induction of long-term potentiation by high-frequency electrical stimulation, synapses between CA3 and CA1 pyramidal neurons were strengthened only when presynaptic input originated in the left CA3, confirming an asymmetry in synaptic properties. The dissociation of hippocampal long-term memory function between hemispheres suggests that memory is routed via distinct left-right pathways within the mouse hippocampus, and provides a promising approach to help elucidate the synaptic basis of long-term memory. U nilateral specializations may facilitate greater processing power in bilateral brain structures by using the available neuronal circuitry more effectively. Nevertheless, the nature of the mechanisms that can act within the confines of duplicate neural structures to support different cognitive functions in each hemisphere remains elusive.The hippocampus is essential for certain forms of learning and memory, both in humans (1) and in rodents (2, 3), and also plays an important role in navigation (4). The left and right mammalian hippocampi comprise the same anatomical areas and directional connectivity, and yet in the human hippocampus, taskrelated activity may be localized to only one hemisphere (5). This lateralization may enable the left and right hippocampus to support complementary functions in human episodic memory, with left hippocampal activity associated with an egocentric, sequential representation of space but greater activity in the right hippocampus when an allocentric representation is used (6). It has been suggested that human hippocampal asymmetry is primarily dictated by external asymmetry-namely, the left hemispheric involvement in language processing and the stronger contribution of the right hemisphere to visuosp...

show abstract

“…Approximately 15–18% of DA neurons in the VTA innervate the vCA1 and vSub, while only half as many DA neurons innervate dHP neurons (75, 76). Hippocampal neurons also receive emotion- and other visceral-relevant information from the amygdala, with the posterior basal medial, medial, and central regions heavily innervating the ventral and dorsal dentate gyrus (77), and the lateral amygdala innervating vSub and vCA1 (40)…”

Section: Neuroanatomical Connectivitymentioning

confidence: 99%

Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms

Kanoski

Grill

2017

Biological Psychiatry

204

188

View full text Add to dashboard Cite

Food intake is a complex behavior that can occur or cease to occur for a multitude of reasons. Decisions about where, when, what, and how much to eat are not merely reflexive responses to food-relevant stimuli or to changes in energy status. Rather, feeding behavior is modulated by various contextual factors and by previous experiences. The data reviewed here support the perspective that neurons in multiple hippocampal subregions constitute an important neural substrate linking the external context, the internal context, and mnemonic and cognitive information to control both appetitive and ingestive behavior. Feeding behavior is heavily influenced by hippocampal-dependent mnemonic functions, including episodic meal-related memories and conditional learned associations between food-related stimuli and postingestive consequences. These mnemonic processes are undoubtedly influenced by both external and internal factors relating to food availability, location, and physiological energy status. The afferent and efferent neuroanatomical connectivity of the subregions of the hippocampus is reviewed with regards to the integration of visuospatial and olfactory sensory information (the external context) with endocrine, gustatory, and gastrointestinal interoceptive stimuli (the internal context). Also discussed are recent findings demonstrating that peripherally-derived endocrine signals act on receptors in hippocampal neurons to reduce (leptin, glucagon-like peptide-1) or increase (ghrelin) food intake and learned food reward-driven responding, thereby highlighting endocrine and neuropeptidergic signaling in hippocampal neurons as a novel substrate of importance in the higher-order regulation of feeding behavior.

show abstract

Organization of Multisynaptic Inputs to the Dorsal and Ventral Dentate Gyrus: Retrograde Trans-Synaptic Tracing with Rabies Virus Vector in the Rat

Cited by 40 publications

References 81 publications

Major diencephalic inputs to the hippocampus

Major diencephalic inputs to the hippocampus

Left–right dissociation of hippocampal memory processes in mice

Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms

Contact Info

Product

Resources

About