Organization of cerebral cortico-olivary projections in the rat

Swenson, Rand S.; Sievert, Carl; Terreberry, R. R.; Neafsey, Edward J.; Castro, Anthony J.

doi:10.1016/0168-0102(89)90036-9

Cited by 29 publications

(22 citation statements)

References 31 publications

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“…Instead, it was concluded that the projection from motor cortex to olive in rats is mainly (if not exclusively) an indirect one. This, however, contrasts with the findings of Swenson et al (1989) who also used anterograde tracing methods in rats and identified a substantial direct ipsilateral olivary projection arising from regions of the motor cortex. A possible explanation for this apparent discrepancy is that in the study by Ackerley et al (2006), tracer injections were made into the motor cortex where microstimulation usually evoked whole forearm or lower limb movements.…”

Section: Cerebro-olivocerebellar Pathwayscontrasting

confidence: 78%

“…A possible explanation for this apparent discrepancy is that in the study by Ackerley et al (2006), tracer injections were made into the motor cortex where microstimulation usually evoked whole forearm or lower limb movements. By contrast, in the study by Swenson et al (1989), tracer injections were made into regions of motor cortex where microstimulation elicited distal movements. This raises the possibility that control of multijoint limb movements (at least in rats) requires a preolivary relay, while control of distal movements may require a direct cerebro-olivary link.…”

Section: Cerebro-olivocerebellar Pathwaysmentioning

confidence: 98%

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Cerebro-Cerebellar Connections

Apps¹,

Watson²

2013

Handbook of the Cerebellum and Cerebellar Disorders

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The cerebro-cerebellar system is one of the largest pathways in the central nervous system, yet knowledge of its structure and function remains far from complete. This is an important gap in understanding because anatomical connectivity is a key determinant of cerebellar function. This chapter focuses on recent advances in understanding the anatomical and physiological properties of cerebro-cerebellar connections in nonhuman species. There are two main routes by which cerebral information can gain access to the cerebellum: cerebro-pontocerebellar pathways that terminate in the cerebellar cortex as mossy fibers and cerebro-olivocerebellar pathways that terminate as climbing fibers. A common principle of organization seems to be the convergence of somatotopically corresponding pathways, with the climbing fiber system playing a key role in imposing this order. In addition to this well-ordered spatial arrangement, there is also precise timing of integration of ascending and descending inputs. The spatial and temporal congruence of inputs is consistent with the one-map hypothesis of cerebellar organization (Apps and Hawkes 2009). The functional significance of this precise arrangement remains to be determined but is likely to have a major impact on cerebellar activity.

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Section: Cerebro-olivocerebellar Pathwayscontrasting

confidence: 78%

Section: Cerebro-olivocerebellar Pathwaysmentioning

confidence: 98%

Cerebro-Cerebellar Connections

Apps¹,

Watson²

2013

Handbook of the Cerebellum and Cerebellar Disorders

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“…It is of interest that these areas are also the recipients of cerebellar input as has been demonstrated in the cat (Bull and Berkley, 1991). The IOD also receives a direct and somatotopically organized input from the somatosensory and dysgranular cortices (Swenson et al, 1989;Lee and Kim, 2012). In the rat it has been shown that the anterior interposed nucleus (IntA) of the cerebellum III.…”

Section: Afferents To the Dorsal Accessory Olivementioning

confidence: 97%

“…The homology between the situation in the cat and that in the rat has not yet been specifically investigated (see also the section below "Afferents to the principal olivary nucleus"). Direct input to the IOM has been described to originate from the sensory and supplementary motorcortices (Swenson et al, 1989;Lee and Kim, 2012). Prominent GABAergic projections arise from the contralateral IntP Fredette and Mugnaini, 1991).…”

Section: Afferents To the Medial Accessory Olivementioning

confidence: 99%

Cerebellum and Cerebellar Connections

Ruigrok

Sillitoe

Voogd

2015

The Rat Nervous System

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“…Tracing (Swenson et al, 1989) and electrophysiological studies in rats show that they also receive inputs from the whisker sensory cortex (Brown and Bower, 2002). …”

Section: Sensory Inputs To the Cerebellummentioning

confidence: 99%

How the cerebellum may monitor sensory information for spatial representation

Rondi-Reig

Paradis

Lefort

et al. 2014

Front. Syst. Neurosci.

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The cerebellum has already been shown to participate in the navigation function. We propose here that this structure is involved in maintaining a sense of direction and location during self-motion by monitoring sensory information and interacting with navigation circuits to update the mental representation of space. To better understand the processing performed by the cerebellum in the navigation function, we have reviewed: the anatomical pathways that convey self-motion information to the cerebellum; the computational algorithm(s) thought to be performed by the cerebellum from these multi-source inputs; the cerebellar outputs directed toward navigation circuits and the influence of self-motion information on space-modulated cells receiving cerebellar outputs. This review highlights that the cerebellum is adequately wired to combine the diversity of sensory signals to be monitored during self-motion and fuel the navigation circuits. The direct anatomical projections of the cerebellum toward the head-direction cell system and the parietal cortex make those structures possible relays of the cerebellum influence on the hippocampal spatial map. We describe computational models of the cerebellar function showing that the cerebellum can filter out the components of the sensory signals that are predictable, and provides a novelty output. We finally speculate that this novelty output is taken into account by the navigation structures, which implement an update over time of position and stabilize perception during navigation.

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Organization of cerebral cortico-olivary projections in the rat

Cited by 29 publications

References 31 publications

Cerebro-Cerebellar Connections

Cerebro-Cerebellar Connections

Cerebellum and Cerebellar Connections

How the cerebellum may monitor sensory information for spatial representation

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