Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues

Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells

“…Complementing these observations, we have shown a significant decrease of the ZO-2A isoform in lung tumors, while the ZO-2C isoform showed no difference as compared to normal tissue. The literature regarding the two described ZO-2 isoforms is extremely scarce and reports that the expression of specific ZO-2 isoforms is dependent on the cell type suggest different biological functions for these two molecules [7]. In agreement with our observations, Chlenski et al [6] have not detected isoform A in pancreatic adenocarcinoma when compared to normal tissues, while isoform C was detected in all tumor samples.…”

“…ZO-2C protein is 23 amino acids shorter at the N-terminus than ZO-2A [6,7]. Three others forms have also been described, two derived from form A and one from form C. However little is known about the potential functional differences between these isoforms.…”

Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair

“…In sub-confluent Coco-2 cells, more Par3 in the nucleus was also observed ( Figure 3B). Collectively, these data indicated that TJ proteins, such as ZO-2, ZO-1 and Par3, may have distinct functions in different sub-cellular localizations [52]. In other words, the data may suggest that epithelial cell polarity may directly connect to nuclear functions through the TJ proteins.…”

Tight junctions at a glance

“…For example, the expression levels of ZO-1 and ZO-2 are dysregulated in different types of cancers and, in the case of breast cancer, low expression of ZO-1 has been correlated with a poor prognosis (Chlenski et al, 2000;Chlenski et al, 1999;Hoover et al, 1998;Kleeff et al, 2001;Martin et al, 2004;Morita et al, 2004;Resnick et al, 2005;Takai et al, 2005). Similarly, several junctional scaffolding proteins are bound and inactivated by viral oncogenes (Glaunsinger et al, 2001;Latorre et al, 2005).…”