Organisms in the Prostate and Antibiotics in the Treatment of Postoperative Infections

Shiina, Hìroaki; Himeno, Yasutoshi; Ishibe, Tomoyuki

doi:10.1159/000282328

Cited by 8 publications

(9 citation statements)

References 7 publications

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“…The rate of detection by FISH was higher than the 35% previously reported for P. acnes by culture (6), which may be attributed to a higher sensitivity of FISH and also the larger proportion of tissue examined by this method. The demonstration of P. acnes in BPH tissues by FISH is in accord with the results of previous reports on the isolation of P. acnes from prostate tissue of patients with idiopathic prostatic inflammation as well as patients with BPH (4,23,27,34,36). However, it is beyond the scope of the present study to draw conclusions on causal associations between infection with P. acnes and the development of BPH or prostate cancer, due to the small number of patient samples analyzed and our in- ability to obtain control prostate tissue from healthy men without prostate disease for comparison.…”

Section: Discussionsupporting

confidence: 91%

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Alexeyev¹,

Marklund²,

Shannon³

et al. 2007

J Clin Microbiol

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Prostate tissues from patients with prostate cancer and benign prostatic hyperplasia (BPH) frequently contain histological inflammation, and a proportion of these patients show evidence of Propionibacterium acnes infection in the prostate gland. We developed a multicolor fluorescent in situ hybridization (FISH) assay targeting P. acnes 23S rRNA along with a 14-kb region of the P. acnes genome. This assay was used to analyze prostate tissues from patients with prostate cancer and BPH. P. acnes infection of the prostate gland was demonstrated in prostatic tissue in 5 of 10 randomly selected prostate cancer patients. FISH analysis and confocal laser microscopy imaging revealed intracellular localization and stromal biofilmlike aggregates as common forms of P. acnes infection in prostate tissues from both prostate cancer and BPH patients. A sequential analysis of prostate tissue from individual patients suggested that P. acnes can persist for up to 6 years in the prostate gland. These results indicate that P. acnes can establish a persistent infection in the prostate gland. Further study is needed to clarify the link between this bacterium and prostatic inflammation which may contribute to the development of BPH and prostate cancer.Clinical benign prostatic hyperplasia (BPH) occurs in half of all men by the age of 80 years (20), while prostate cancer is a leading cause of morbidity and death among men in the United States and Western Europe (13). Chronic or recurrent inflammation has been implicated in the development and progression of both BPH (20) and prostate cancer (9,24,25,30), and various degrees of histological inflammation are seen in the majority of prostate tissue specimens examined. The possibility of an infectious etiology for this prostatic inflammation has been raised in the context of both BPH (20) and prostate cancer, although the accumulation of a larger amount of evidence supports this hypothesis for the latter. For example, epidemiological studies have reported an increased risk of prostate cancer in patients with a history of sexually transmitted infections (29,31,32). The genetic signatures of bacteria were found in prostate tissues from 21 of 107 patients with prostate cancer (21). Moreover, a positive correlation between prostatic inflammation and the detection of bacterial 16S rRNA gene sequences in tissue specimens obtained by radical prostatectomy has been reported (16).Recently, a single bacterial species, Propionibacterium acnes, has been shown to infect a considerable proportion (35%) of prostate glands removed at radical prostatectomy (6). Moreover, the presence of P. acnes was strongly correlated with histological inflammation, suggesting that this bacterium might be linked to cancer development. The possible involvement of P. acnes in prostate pathology was further highlighted by the detection of P. acnes 16S rRNA gene sequences in BPH tissues, with a positive association between the detection of P. acnes DNA and subsequent prostate cancer development reported (1). We have developed ...

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Section: Discussionsupporting

confidence: 91%

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Alexeyev¹,

Marklund²,

Shannon³

et al. 2007

J Clin Microbiol

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“…Former investigations already reported a colonization of prostatic tissue by bacteria [2,5,6,8]. No clear clinical relevance could be ascertained before.…”

Section: Discussionmentioning

confidence: 99%

“…So far, less evidence exists in terms of clinical symptoms and their relation to bacterial colonization of the prostatic gland [2,3,4,5,6,7,8]. No study data exist about whether some types of bacteria might have a positive, negative or no effect on the prostate gland, and the direct connection between bacterial colonization and clinical symptoms is yet to be made.…”

Section: Introductionmentioning

confidence: 99%

Diversity of Bacterial Urine and Prostate Gland Tissue Cultures in Patients Undergoing Transurethral Prostate Gland Resection

Heidler¹,

Bretterbauer²,

Schwarz³

et al. 2016

Urol Int

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Introduction: The objective of this study was to identify the types of bacterial colonization of the prostate gland tissue and urine pre- and postoperatively in patients undergoing a transurethral resection (TUR) of the prostate gland. In addition, clinical symptoms and histopathological findings were included. Material and Methods: Forty three patients were investigated. Urine test strips and urine cultures were taken pre- and postoperatively and intraoperatively prostate resection chips were taken for culture. Results: A positive bacterial culture was found in 20 of 43 (46.5%) patients. Preoperatively, a positive bacterial culture was found in 12 patients and postoperatively in 7 patients. Thirteen patients showed a positive culture of the prostate gland tissue. No patient showed the same bacterial isolates in all 3 samples. Postinterventionally, 6 patients of the group with positive bacterial cultures developed complications. From the group of patients without bacterial growth, only one patient developed a postoperative complication. Conclusion: The bacterial colonization in the 3 different cultures showed an inhomogeneous spectrum of bacteria without a reproducible pattern. Nevertheless, it clearly demonstrates that the group with a positive culture is at great risk to develop postoperative complications.

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“…They included preoperative factors (age, ASA III/IV patients, increased serum creatinine, lack of antibiotic prophylaxis, acute urine retention, preoperative catheter drainage, and preoperative bacteriuria) and postoperative factors (increased duration of catheterization, nonclosed drainage system) [1, 2, 8, 9, 10, 11, 12, 13]. The multivariate analysis performed in this study confirms that preoperative bacteriuria is a risk factor of postoperative infection and identified 2 other risk factors: a surgical procedure lasting more than 70 min, and the center where the procedure was performed.…”

Section: Discussionmentioning

confidence: 99%

“…We chose to perform urine culture 24 h after the bladder catheter had been withdrawn, because the majority of the patients were discharged soon after, and because most of the surgeons considered that a positive urine culture in such circumstances justified an antibiotic therapy [12]. In our study, a positive urine culture was the most common feature of infection, occurring in 162 patients (19.3%); the postoperative rate of bacteremia and/or septic shock was 2.3%.…”

Section: Discussionmentioning

confidence: 99%

Infection after Transurethral Resection of the Prostate: Variation among Centers and Correlation with a Long-Lasting Surgical Procedure

et al. 1998

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Organisms in the Prostate and Antibiotics in the Treatment of Postoperative Infections

Cited by 8 publications

References 7 publications

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Diversity of Bacterial Urine and Prostate Gland Tissue Cultures in Patients Undergoing Transurethral Prostate Gland Resection

Infection after Transurethral Resection of the Prostate: Variation among Centers and Correlation with a Long-Lasting Surgical Procedure

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