Organische Synthese mit mikrostrukturierten Reaktoren
Abstract: (1) 1 µm (2)1 µm M i k r o r e a k t o r e n 535
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Cited by 10 publications
References 51 publications
The sections in this article are Introduction and Definitions Introduction Historical Aspects Definition of Quality: Product Functionality Quality Control Quality Assurance Management and Strategy PAT Initiative PAT Toolbox The Concept of Quality by Design ( Qb D ) ICH The Concept of a Design Space Implications for Other Branches of the Life Sciences General Remarks Biotechnology Food Industry Summary and Outlook Toolboxes for Process Control and Understanding Introduction: Causality Sampling Process Validation Role of Design of Experiments ( Do E ) Role of Failure Mode and Effects Analysis ( FMEA ) Measurement Technologies (How to Measure) Selection of the Appropriate Technique Working in Aqueous Systems Trace Analysis Qualification of a Spectrometer Data Analysis and Calibration (How to Process Data and How to Calibrate) Introduction Spectral Data Pretreatments and Data Cleaning Chemometrics Regression Analysis Process Control (How to Control a Process) Specific Problems Encountered in Industrial Process Analytics Moisture Measurements ( NIR , MW ) NIR Spectroscopy Microwave Resonance Technique ( MWR ) Process Analytics of Solids and Surfaces: Specular and Diffuse Reflectance Working in Multiple Scattering Systems: Separating Scatter from Absorbance Basics in the Measurement of Opaque Systems Separation of Scatter from Absorption Optical Penetration Depth Spectral Imaging and Multipoint Spectroscopy Survey Through Industrial Applications Selection of Applications Pharmaceutical Industry UV /Vis Spectroscopy NIR Spectroscopy Raman Spectroscopy Imaging Techniques Food and Agriculture UV /Vis Spectroscopy NIR Spectroscopy Raman Spectroscopy Imaging Techniques Polymers UV /Vis Spectroscopy NIR Spectroscopy Raman Spectroscopy Imaging Techniques Perspectives Technology Roadmap 2015+ Medical Applications and Tomographic Imaging Multi‐ Point‐Information Systems in Manufacturing Multimodal Spatially Resolved Spectroscopy Microreactor Control and Reaction Tomography
The sections in this article are Introduction and Definitions Introduction Historical Aspects Definition of Quality: Product Functionality Quality Control Quality Assurance Management and Strategy PAT Initiative PAT Toolbox The Concept of Quality by Design ( Qb D ) ICH The Concept of a Design Space Implications for Other Branches of the Life Sciences General Remarks Biotechnology Food Industry Summary and Outlook Toolboxes for Process Control and Understanding Introduction: Causality Sampling Process Validation Role of Design of Experiments ( Do E ) Role of Failure Mode and Effects Analysis ( FMEA ) Measurement Technologies (How to Measure) Selection of the Appropriate Technique Working in Aqueous Systems Trace Analysis Qualification of a Spectrometer Data Analysis and Calibration (How to Process Data and How to Calibrate) Introduction Spectral Data Pretreatments and Data Cleaning Chemometrics Regression Analysis Process Control (How to Control a Process) Specific Problems Encountered in Industrial Process Analytics Moisture Measurements ( NIR , MW ) NIR Spectroscopy Microwave Resonance Technique ( MWR ) Process Analytics of Solids and Surfaces: Specular and Diffuse Reflectance Working in Multiple Scattering Systems: Separating Scatter from Absorbance Basics in the Measurement of Opaque Systems Separation of Scatter from Absorption Optical Penetration Depth Spectral Imaging and Multipoint Spectroscopy Survey Through Industrial Applications Selection of Applications Pharmaceutical Industry UV /Vis Spectroscopy NIR Spectroscopy Raman Spectroscopy Imaging Techniques Food and Agriculture UV /Vis Spectroscopy NIR Spectroscopy Raman Spectroscopy Imaging Techniques Polymers UV /Vis Spectroscopy NIR Spectroscopy Raman Spectroscopy Imaging Techniques Perspectives Technology Roadmap 2015+ Medical Applications and Tomographic Imaging Multi‐ Point‐Information Systems in Manufacturing Multimodal Spatially Resolved Spectroscopy Microreactor Control and Reaction Tomography
A 2D non-isothermal reaction engineering model for a tubular reactor was developed for a complex reaction network of salicylic acid nitration. The influence of different operating and design parameters was studied to minimize the amount of secondary nitration products and limit the maximum temperature inside the reactor. Critical temperature effects were observed for larger reaction tubes, whereas close to isothermal conditions were perceived in smaller tubes. With single-point dosing of both reactants, complete conversion can be achieved but formation of secondary nitration products cannot be avoided. For a given number of dosing points, a suitable combination of the operating parameters allowed to achieve complete conversion and better yield of the desired product.
Reaktions-und sicherheitstechnische Aspekte der Umwandlung eines diskontinuierlichen chemischen Prozesses in ein kontinuierliches Verfahren unter Verwendung von Mikroreaktoren werden untersucht. Ausgangspunkt ist der diskontinuierliche Prozess mit seiner Produktqualität, die bei der Umwandlung erhalten bleiben soll. Geeignet für eine Umwandlung sind besonders schnelle, stark exotherme, homogene Flüssigphase-Reaktionen. Die thermisch sichere Auslegung von Mikroreaktoren hängt von der Geschwindigkeit der Reaktion ab und wird für zwei Grenzfälle behandelt. Als Anwendungsbeispiel wird eine technisch durchgeführte Fluorierungsreaktion vorgestellt.
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