Organically modified montmorillonite as pH versatile carriers for delivery of 5-aminosalicylic acid

Dumitru, Marinela Victoria; Sandu, Teodor; Ciurlică, Ana Lorena; Neblea, Iulia Elena; Trică, Bogdan; Ghebaur, Adi; Gârea, Sorina Alexandra; Iovu, Horia; Sârbu, Andrei; Iordache, Tanta‐Verona

doi:10.1016/j.clay.2022.106415

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…To establish the viability of 5-ASA after ALD, we study the FTIR spectra of the samples first. The detailed FTIR spectrum of uncoated 5-ASA is well studied in the literature − and is also provided in Supporting Information S1 for the present powder along with the peak assignments table. We provide a comparison between the ATR-FTIR spectra of the control (i.e., uncoated 5-ASA), 300CyAl 2 O 3 @5-ASA, and 200CyZnO@5-ASA in Figure a.…”

Section: Resultsmentioning

confidence: 99%

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al₂O₃ and ZnO in an Acidic Environment

Sosa

Berriel

Feit

et al. 2022

ACS Appl. Bio Mater.

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5-Aminosalicylic acid (5-ASA) is a first-line defense drug used to treat mild cases of inflammatory bowel disease. When administered orally, the active pharmaceutical ingredient is released throughout the gastrointestinal tract relieving chronic inflammation. However, delayed and targeted released systems for 5-ASA to achieve optimal dose volumes in acidic environments remain a challenge. Here, we demonstrate the application of atomic layer deposition (ALD) as a technique to synthesize nanoscale coatings on 5-ASA to control its release in acidic media. ALD Al 2 O 3 (38.0 nm) and ZnO (24.7 nm) films were deposited on 1 g batch powders of 5-ASA in a rotatory thermal ALD system. Fourier transform infrared spectroscopy, scanning electron microscopy, and scanning/transmission electron microscopy establish the interfacial chemistry and conformal nature of ALD coating over the 5-ASA particles. While Al 2 O 3 forms a sharp interface with 5-ASA, ZnO appears to diffuse inside 5-ASA. The release of 5-ASA is studied in a pH 4 solution via UV−vis spectroscopy. Dynamic stirring, mimicking gut peristalsis, causes mechanical attrition of the Al 2 O 3 -coated particles, thereby releasing 5-ASA. However, under static conditions lasting 5000 s, the Al 2 O 3 -coated particles release only 17.5% 5-ASA compared to 100% release with the ZnO coating. Quartz crystal microbalance-based etch studies confirm the stability of Al 2 O 3 in pH 4 media, where the ZnO films etch 41× faster than Al 2 O 3 . Such results are significant in achieving a nanoscale coating-based drug delivery system for 5-ASA with controlled release in acidic environments.

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Section: Resultsmentioning

confidence: 99%

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al₂O₃ and ZnO in an Acidic Environment

Sosa

Berriel

Feit

et al. 2022

ACS Appl. Bio Mater.

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“…In the last decades, researchers have also paid close attention to the use of kaolin (K)-based minerals, because they are cheaper than other minerals, they can act as an active excipient in solid and semi-solid pharmaceuticals, and they can control the effectiveness of dosage forms, which leads to improved bioavailability of the drug [ 43 , 44 , 45 , 46 , 47 , 48 ]. Among the remarkable properties of K, it is worth mentioning its chemical, thermal, and morphological stability and also some physical properties, such as crystallinity, porosity, specific surface area, particle size, and lack of abrasiveness [ 47 , 48 , 49 , 50 , 51 ]. The major drawback of K is its lower surface area, related to problematic exfoliation procedures, as compared to other minerals such as montmorillonite.…”

Section: Introductionmentioning

confidence: 99%

“…The major drawback of K is its lower surface area, related to problematic exfoliation procedures, as compared to other minerals such as montmorillonite. However, scientists have found additional strategies for increasing the active surface area of kaolin, in terms of chemical surface modification [ 45 , 48 , 49 ]. Nevertheless, other issues that need solving are encountered when using natural clays in the preparation of materials.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Cryogels with Superabsorbent Properties as Promising Materials for Penicillin G Retention

Dumitru

Sandu

Miron

et al. 2023

Gels

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This present study describes the investigation of new promising hybrid cryogels able to retain high amounts of antibiotics, specifically penicillin G, using chitosan or chitosan–biocellulose blends along with a naturally occurring clay, i.e., kaolin. In order to evaluate and optimize the stability of cryogels, three types of chitosan were used in this study, as follows: (i) commercial chitosan; (ii) chitosan prepared in the laboratory from commercial chitin; and (iii) chitosan prepared in the laboratory from shrimp shells. Biocellulose and kaolin, previously functionalized with an organosilane, were also investigated in terms of their potential to improve the stability of cryogels during prolonged submergence under water. The organophilization and incorporation of the clay into the polymer matrix were confirmed by different characterization techniques (such as FTIR, TGA, SEM), while their stability in time underwater was investigated by swelling measurements. As final proof of their superabsorbent behavior, the cryogels were tested for antibiotic adsorption in batch experiments, in which case cryogels based on chitosan extracted from shrimp shells seem to exhibit excellent adsorption properties for penicillin G.

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“…Compared with the two-dimensional structure, the three-dimensional cubic cage structure has a larger cage diameter, but a smaller pore entrance and pore channel, which is more conducive to drug administration [ 26 , 27 , 28 ]. Therefore, it is more meaningful to use SBA-16 as a nano-drug carrier in this study [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. However, pH-responsive composites prepared with SBA-16 as the carrier, indoleomycin as the carrier center, and gel polymer as the coating agent have not been reported.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin

Shi

Liu

et al. 2023

Heliyon

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Organically modified montmorillonite as pH versatile carriers for delivery of 5-aminosalicylic acid

Cited by 9 publications

References 34 publications

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al₂O₃ and ZnO in an Acidic Environment

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al₂O₃ and ZnO in an Acidic Environment

Hybrid Cryogels with Superabsorbent Properties as Promising Materials for Penicillin G Retention

pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin

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Organically modified montmorillonite as pH versatile carriers for delivery of 5-aminosalicylic acid

Cited by 9 publications

References 34 publications

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al2O3 and ZnO in an Acidic Environment

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al2O3 and ZnO in an Acidic Environment

Hybrid Cryogels with Superabsorbent Properties as Promising Materials for Penicillin G Retention

pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin

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Product

Resources

About

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al₂O₃ and ZnO in an Acidic Environment

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al₂O₃ and ZnO in an Acidic Environment