Organic Zn and Cu interaction impact on sexual behaviour, semen characteristics, hormones and spermatozoal gene expression in bucks (Capra hircus)

Krishnaiah, M. Venkata; Arunachalam, A.; Selvaraju, Sellappan; Guvvala, Pushpa Rani; Ramesh, K. J.

doi:10.1016/j.theriogenology.2019.02.026

Cited by 16 publications

(11 citation statements)

References 38 publications

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“…In addition, the levels of Ca and Mg in semen showed a positive correlation with sperm concentration, sperm motility, and normal morphology [ 43 ]. The research carried out by Venkata Krishnaiah et al [ 50 ] investigated the effect of supplementation on the quality of goat sperm. The study included 40 goats divided into 10 groups, the control group was fed a basic diet, without additional supplementation, and the research groups received appropriate doses of zinc (20, 40, 60 mg of Zn), copper (12.5, 25, 37.5 mg Cu) and zinc along with copper (20 mg Zn + 12.5 mg Cu, 40 mg Zn + 25 mg Cu, 60 mg Zn + 37.5 mg Cu) for 26 weeks.…”

Section: Electrolyte Balancementioning

confidence: 99%

“…However, in the case of supplementation with 20 mg and 60 mg of zinc, higher testosterone contents (about five and 5.5 ng/mL, respectively) were obtained than in the control sample. The authors suggest that supplementation with zinc and copper, or a combination of Zn and Cu, may accelerate male maturation by about a month, and improve sperm quality [ 50 ].…”

Section: Electrolyte Balancementioning

confidence: 99%

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Reproductive Consequences of Electrolyte Disturbances in Domestic Animals

Gałęska

Wrzecińska

Kowalczyk

et al. 2022

Biology

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Electrolyte balance is essential to maintain homeostasis in the body. The most crucial electrolytes are sodium (Na+), potassium (K+), magnesium (Mg2+), chloride (Cl−), and calcium (Ca2+). These ions maintain the volume of body fluids, and blood pressure, participate in muscle contractions, and nerve conduction, and are important in enzymatic reactions. The balance is mainly ensured by the kidneys, which are an important organ that regulates the volume and composition of urine, together with which excess electrolytes are excreted. They are also important in the reproductive system, where they play a key role. In the male reproductive system, electrolytes are important in acrosomal reaction and sperm motility. Sodium, calcium, magnesium, and chloride are related to sperm capacitation. Moreover, Mg2+, Ca2+, and Na+ play a key role in spermatogenesis and the maintenance of morphologically normal spermatozoa. Infertility problems are becoming more common. It is known that disturbances in the electrolyte balance lead to reproductive dysfunction. In men, there is a decrease in sperm motility, loss of sperm capacitation, and male infertility. In the female reproductive system, sodium is associated with estrogen synthesis. In the contraction and relaxation of the uterus, there is sodium, potassium, and calcium. Calcium is associated with oocyte activation. In turn, in women, changes in the composition of the follicular fluid are observed, leading to a restriction of follicular growth. Imbalance of oocyte electrolytes, resulting in a lack of oocyte activation and, consequently, infertility.

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Section: Electrolyte Balancementioning

confidence: 99%

Section: Electrolyte Balancementioning

confidence: 99%

Reproductive Consequences of Electrolyte Disturbances in Domestic Animals

Gałęska

Wrzecińska

Kowalczyk

et al. 2022

Biology

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“…These cattle tend to browse arboreal and shrubby vegetation, consume fruits and a variety of herbaceous plants and grasses that specialized cattle do not normally consume ( Anderson et al, 2015 ; Armstrong et al, 2022 ). It is known that the type of diet consumed by animals results in changes in gene expression in different tissues and cells, including sperm ( Shibata et al, 2014 ; Krishnaiah et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Raramuri Criollo bulls have good semen quality throughout the year and high testosterone concentrations ( Quezada-Casasola et al, 2018 ), however, ensuring semen quality measured in the conventional way does not guarantee embryo viability ( Franco et al, 2020 ). Therefore, in recent years, in addition to the conventional analyses of seminal quality and viability, important biochemical and physiological indicators for achieving successful pregnancy are being implemented ( Atabay et al, 2019 ; Krishnaiah et al, 2019 ; Franco et al, 2020 ). These analyses might include molecular biomarkers such as: metabolites, enzymes and RNAs ( Le Blévec et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Expression of PLCZ1 mRNA in spermatozoa of Criollo and European bulls in a low-input system

Ronquillo-Roacho,

Rodriguez-Almeida,

Antillón-Ruiz

et al. 2023

Anim. Reprod.

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Sperm motility and kinematics analysis are important to predict bull fertility. However, there are other molecules in the sperm with the ability to improve the pregnancy rate. For example, PLCZ1 is a sperm protein that plays a unique role in the activation of the zygote and is important for the survival of the embryo. The objective of this work was to compare the expression of PLCZ1 mRNA in sperm cells of Chihuahuan Criollo and European bulls in the winter and summer seasons, under a low-input system. Six (3.33 ± 0.43 years old) bulls (three Criollo, three European) were used. Gross and individual motility were measured in semen obtained by electrostimulation. The cell pack was pelletized by centrifugation and stored in liquid nitrogen. The sperm cells were purified and total RNA was extracted. cDNA was synthesized to perform qPCR and measure the relative level of PLCZ1 transcripts in each bull. There were no differences in individual motility, however, gross motility was lower (P < 0.05) in Criollo bulls, both in the winter (71.1 ± 2.8 vs. 76.6 ± 2.8%) and in the summer season (58.9 ± 2.8 vs. 77.7 ± 2.8%). PLCZ1 expression was 5.3 times higher (P < 0.05) in winter than in summer (5.09 ± 1.09 vs 0.959 ± 1.09). No difference (P>0.05) was found in the expression levels of PLCZ1 between both breeds (4.36 ± 1.09 vs 1.69 ± 1.09), for Criollo and European, respectively. Although the animals presented seminal motility within the recommended limits for insemination, the expression levels of PLCZ1 vary depending on the time of the year and this might impact the rate of successful pregnancies. Therefore, it is important to complement conventional analysis of seminal quality with molecular characteristics.

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“…Zn 2+ concentrations in seminal plasma have been reported to be positively correlated with sperm concentration in different species such as humans, caprine and bovine (Venkata Krishnaiah et al., 2019; Zhao et al., 2016). Also, men with prostatic cancer have lower prostatic fluid Zn 2+ concentration when compared with healthy subjects or those affected with chronic prostatitis (Zaichick et al., 1996).…”

Section: Introductionmentioning

confidence: 99%

Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate

Ferré-Dolcet

Frigotto

Contiero

et al. 2021

Reprod Domestic Animals

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Benign prostatic hyperplasia (BPH) may alter prostatic fluid biochemical composition causing reduced fertility. Osaterone acetate (OA) is an androgen receptor antagonist marketed for treatment of canine BPH. Little information exists on effects of OA administration on biochemical composition of canine prostatic fluid and its role on fertility. The aim of this research was to study biochemical composition of prostatic fluid and its role on semen quality in dogs with BPH undergoing treatment with OA.Eight intact, 5-11-year-old dogs with benign prostatic hyperplasia were treated orally with OA at a dose of 0.25-0.5 mg/kg once daily for seven days. Prostatic volume, semen evaluation and a biochemical analysis of prostatic fluid were performed on the day before treatment (D0), D60, D120, D180 and D240. A significant reduction (57% and 61%) of prostatic volume was observed at D60 and D120, respectively, and a significant reduction (20%) of normal spermatozoa was observed at D60 coincident with a significant increase of sperm tail defects, which disappeared during the course of the treatment. Prostatic fluid composition did not vary during the OA treatment except for zinc (Zn 2+ ) with a significant increase at D120 and D180 correlated with the return to normal sperm values. In conclusion, canine Zn 2+ prostatic fluid concentrations decrease during development of BPH and return to normal during treatment with OA. Zn 2+ is an important electrolyte for semen quality, suggesting that oral Zn 2+ supplementation might be considered a treatment to improve semen quality.

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Organic Zn and Cu interaction impact on sexual behaviour, semen characteristics, hormones and spermatozoal gene expression in bucks (Capra hircus)

Cited by 16 publications

References 38 publications

Reproductive Consequences of Electrolyte Disturbances in Domestic Animals

Reproductive Consequences of Electrolyte Disturbances in Domestic Animals

Expression of PLCZ1 mRNA in spermatozoa of Criollo and European bulls in a low-input system

Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate

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