Organic Synthesis of Substituted Chlorinated Benzenesulfonamides as Selective Inhibitors of Several CA Isoforms

Čapkauskaitė, Edita; Matulis, Daumantas

doi:10.1007/978-3-030-12780-0_10

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…The chemical compounds were synthesized and purified, and their purity was confirmed by thin-layer chromatography and/or high pressure (or high performance) liquid chromatography and the identity by HRMS, by elemental analysis and by proton, carbon and, when available, fluorine NMR as previously described and reviewed ( 17 , 30 , 31 ).…”

Section: Methodsmentioning

confidence: 99%

PLBD: protein–ligand binding database of thermodynamic and kinetic intrinsic parameters

Lingė,

Gedgaudas,

Merkys

et al. 2023

Database

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We introduce a protein–ligand binding database (PLBD) that presents thermodynamic and kinetic data of reversible protein interactions with small molecule compounds. The manually curated binding data are linked to protein–ligand crystal structures, enabling structure–thermodynamics correlations to be determined. The database contains over 5500 binding datasets of 556 sulfonamide compound interactions with the 12 catalytically active human carbonic anhydrase isozymes defined by fluorescent thermal shift assay, isothermal titration calorimetry, inhibition of enzymatic activity and surface plasmon resonance. In the PLBD, the intrinsic thermodynamic parameters of interactions are provided, which account for the binding-linked protonation reactions. In addition to the protein–ligand binding affinities, the database provides calorimetrically measured binding enthalpies, providing additional mechanistic understanding. The PLBD can be applied to investigations of protein–ligand recognition and could be integrated into small molecule drug design. Database URL https://plbd.org/

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Section: Methodsmentioning

confidence: 99%