Organic solvent-free synthesis of sulfonyl hydrazides in water

Abstract

An organic solvent-free synthesis of sulfonyl hydrazides has been achieved in water. The reactions of equimolar amount of sulfonyl chlorides and hydrazines afforded a series of substituted sulfonyl hydrazides at 60 °C for 1 h in water as a solvent in the presence of triethylamine when hydrazines are hydrochlorides. Moderate to good yields were observed for this transformation by the simple operation (46-81 %). The reaction of amines, anilines, alcohol, and phenol have also been investigated in water.