This paper assesses the efficiency of various electrode combinations in treating Refinery Wastewater (RWW) using electrocatalytic oxidation (ECO) to determine the optimal operating conditions in the reactor, specifically focusing on energy consumption for organic removal. The Box-Behnken experimental design and ANOVA analysis were employed for this investigation. The applied potential across all electrodes was identified as the most influential operating parameter. X-ray diffraction analysis confirmed the typical crystalline nature of the by-products formed, which were predominantly amorphous or poorly crystalline in structure. During the Electrochemical Sequential Chlorination (ESC) process, various oxidants including active chlorine species and oxidizing radicals were generated, contributing to the oxidation of organic compounds in the aqueous solution. Additionally, the functional groups present in zinc oxide were characterized using Fourier Transform Infrared (FT-IR) spectroscopy. The study yielded a maximum organic removal efficiency of 98.2%. Furthermore, it was observed that the operating conditions of the electrodes exhibited similar trends in specific energy consumption (SEC) for organic removal, with an energy consumption of 39.11 kWh/m 3 .